Express Imodium 2mg tab-lyophilisate 10 pc

$6.37

Express Imodium 2mg tab-lyophilisate 10 pc

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SKU: 0853509610 Categories: , , Tags: ,

Description

Composition
Active substance:
1 tablet contains: loperamide hydrochloride 2 mg.
Excipients:
Gelatin 5.863 mg Mannitol 4.397 mg, 0.750 mg aspartame, mint flavor 0.300 mg, 0.375 mg of sodium hydrogencarbonate.
Description:
White or almost white round tablets freeze-dried.
Imodium® tablets with unique technology Zaydis, dissolve on the tongue and do not require zapivaniya water.
Product form:
Primary package: 6 or 10 tablets lyophilised in a blister aluminum / aluminum.
Secondary Packaging: 1 blister (6 or 10 tablets) or 2 blisters (10 tablets), together with instructions for medical use in a cardboard package.
Contraindications
Imodium® Express lyophilized tablets should not be used in children under the age of 6 years.
Imodium® Express contraindicated in patients with hypersensitivity to loperamide and / or any of the components, as well as in the first trimester of pregnancy.
Imodium® Express is not recommended during breast-feeding.
Imodium® Express lyophilized tablets contraindicated in patients with phenylketonuria.
Imodium® Express can not be used as primary therapy: – in patients with acute dysentery, which is characterized by bloody stools and high temperature; – in patients with ulcerative colitis in the acute stage; – in patients with bacterial enterocolitis caused by pathogens, including Salmonella, Shigella and Campylobacter; – in patients with pseudomembranous colitis associated with antibiotic therapy of a wide spectrum of action.
Express Imodium® should not be used in cases where undesirable slowing of peristalsis due to the possible risk of serious complications, including ileus, megacolon and toxic megacolon.
Imodium® Express should immediately cancel the appearance of constipation, bloating or intestinal obstruction.
Carefully
Imodium® Express should be used with caution in patients with impaired liver function due to slow first-pass metabolism.
Dosage
2 mg
Indications
Symptomatic treatment of acute and chronic diarrhea (genesis: allergic, emotional, drug, radiation, with a change in diet and qualitative composition of food, in violation of metabolism and absorption). As a subsidiary drug for diarrhea infectious genesis. Regulation of stool in patients with iliostoma.
Interaction with other drugs
According to preclinical studies loperamide is a substrate for P-glycoprotein. With simultaneous use of loperamide (single dose of 16 mg) and quinidine or ritonavir are inhibitors of P-glycoprotein, loperamide concentration in plasma increased by 2-3 times. Clinical significance described pharmacokinetic interactions with inhibitors of P-glycoprotein in the application of loperamide in the recommended doses known.
The simultaneous use of loperamide (a single dose of 4 mg) and itraconazole, an inhibitor of isozyme CYP3A4 and P-glycoprotein, resulting in increased plasma concentrations of loperamide 3-4 times. In the same study, the use of an inhibitor of isozyme CYP2C8, gemfibrozil, has led to an increase in the plasma concentration of loperamide about 2 times.
When applying the combination of itraconazole and gemfibrozil loperamide peak concentration in the blood plasma increased 4 times, and the total concentration of – 13 times. This increase was not due to the influence of the central nervous system, as measured by psychomotor tests (ie. E. A subjective evaluation of sleepiness and test replacement numeric characters).
The simultaneous use of loperamide (single dose of 16 mg) and ketoconazole, an inhibitor of CYP3A4 and P-glycoprotein led to a fivefold increase loperamide plasma concentrations. This increase was not associated with increased pharmacodynamic effects, measured by the value of the pupil.
With the simultaneous oral administration of desmopressin desmopressin plasma concentration increased by 3 times, probably because of the slow motility of the gastrointestinal tract.
That drugs with similar expected pharmacological properties can exacerbate the effects of loperamide, and drugs that increase the rate of passage through the gastrointestinal tract, may reduce the effect of loperamide.
Overdose
symptoms
In overdose (including relative overdose due to abnormal liver function) may appear urinary retention, paralytic ileus, features, depression of the central nervous system (CNS): stupor, coordination disorder, somnolence, cramps, muscle hypertonicity, respiratory depression. Children may be more sensitive to the effects of loperamide on the central nervous system than adults.
Therapy
When the overdose symptoms as an antidote naloxone may be used. Since the duration of action of loperamide is greater than naloxone (1-3 hours) may require repeated application of naloxone.
Therefore, you must carefully observe the condition of the patient for at least 48 hours in order to timely detect possible signs of CNS depression.
pharmachologic effect
Pharmacological group:
Antidiarrheals.
Pharmacodynamics:
Loperamide binding to opioid receptors in the intestinal wall and inhibits the release of acetylcholine and prostaglandins, thus slowing and increasing the motility of the passage of the contents through the intestine. Increases tonus of the anal sphincter, thereby reducing fecal incontinence and urge to defecate.
Pharmacokinetics:
Most of loperamide absorbed in the intestine, but due to presystemic metabolism of the active systemic bioavailability is about 0.3%.
These preclinical studies suggest that loperamide is a substrate for P-glycoprotein. loperamide binding to plasma proteins (mainly albumin) is 95%.
Loperamide primarily metabolized in the liver, conjugated and excreted in the bile. Oxidative N-demethylation of the main route of metabolism and loperamide performed advantageously with the assistance of an inhibitor of isozyme SYP3A4 and CYP2C8. Because the active first-pass metabolism in the blood plasma concentration of unchanged loperamide negligible.
In humans, the half-life of loperamide averages 11 hours, varying from 9 to 14 hours. Unmodified loperamide and its metabolites are excreted primarily in the feces.
Pharmacokinetic studies in children have not been conducted. That the pharmacokinetics of loperamide expected and its interactions with other drugs are similar to those in adults.
Pregnancy and breast-feeding
Use during pregnancy
Data that loperamide teratogenic or embryotoxic effects are absent.
During the first trimester of pregnancy is contraindicated reception Imodium® Express.
During the II-III trimesters of pregnancy use Imodium® Express is possible only after consultation with your doctor. The drug can be used only if the expected benefit of therapy for the mother outweighs the potential risk to the fetus.
Use during breastfeeding
A small amount of loperamide can pass into breast milk, so Imodium® Express is not recommended during breast-feeding.
Conditions of supply of pharmacies
Without recipe.
side effects
Adverse reactions – this undesirable phenomenon, which should be considered to prove a causal connection with the use of loperamide on the basis of a comprehensive assessment of the available information on adverse events.
In some cases, quite difficult to reliably establish a causal relationship between taking loperamide and the emergence of these symptoms. Further, since clinical studies carried out under various conditions, the incidence of adverse reactions in clinical studies of the drug can not be directly compared with the frequency of adverse reactions in clinical studies of another drug and may not reflect the frequency of adverse reactions in clinical practice.
According to clinical studies
Adverse reactions observed in> 1% of patients taking Imodium® Express in acute diarrhea: headache, constipation, flatulence, nausea, vomiting.
Adverse reactions observed in
Adverse reactions observed in> 1% of patients taking Imodium® Express for chronic diarrhea dizziness, flatulence, constipation, nausea.
Adverse reactions observed in
According to the spontaneous reactions of unwanted messages
The following adverse reactions were classified as follows: very often (> 10%), frequent (> 1% but
special instructions
diarrhea treatment with Imodium® Express is only symptomatic. In those cases where it is possible to establish the cause of diarrhea, it is necessary to conduct appropriate therapy.
In patients with diarrhea, especially in children, may have been loss of fluids and electrolytes. In such cases it is necessary to carry out appropriate replacement therapy (replenishment of fluids and electrolytes).
Imodium® Express lyophilized tablets contain a source of phenylalanine. Admission is contraindicated in patients with phenylketonuria.
If no effect after 2 days of treatment should stop taking the drug, specify the diagnosis and rule out infection genesis of diarrhea.
AIDS patients taking Imodium® Express to treat diarrhea should stop taking the drug at the first sign of bloating. There have been isolated reports of constipation with an increased risk of toxic megacolon in AIDS patients, and infectious colitis, viral and bacterial etiology, which was carried out with loperamide therapy.
Although data on the pharmacokinetics of loperamide in patients with hepatic insufficiency are absent in these patients Imodium® Express should be used with caution due to the slow first-pass metabolism, as this may result in a relative overdose and toxic CNS lesions.
If the drug became useless or expired shelf life – do not throw it in the waste water and the street! Place the drug in the bag and place in the trash. These measures will help protect the environment!
Effect on the ability to drive mechanisms and
During drug treatment Imodium® Express should refrain from driving a vehicle and other activities potentially hazardous activities that require high concentration and speed of psychomotor reactions, because the drug can cause dizziness and other side effects that may affect these abilities.
Storage conditions
Store at a temperature of from 15 to 30 ° C.
Keep out of the reach of children.
Store in original container.
Dosing and Administration
Inside. A tablet is placed on the tongue for a few seconds, it dissolves, then swallow it with saliva without drinking water.
Adults and children over 6 years:
Acute diarrhea: the initial dose – 2 tablets (4 mg) for adults and 1 tablet (2 mg) for children, then 1 tablet (2 mg) after each defecation in the case of liquid stool.
Chronic diarrhea: the initial dose – 2 tablets (4 mg) per day for adults and 1 tablet (2 mg) for children; more initial dose should be adjusted so that normal stool frequency was 1-2 times per day, which is usually achieved with the maintenance dose from 1 to 6 Tablets (2-12 mg) per day.
The maximum daily dose should not exceed 6 tablets (12 mg); the maximum daily dose for children is calculated based on body weight (3 tablets of 20 kg body weight), but should not exceed 6 tablets (12 mg).
By normalizing stool or chair in the absence of a 12 h drug overturned.
Use in children
Do not use Imodium® Express in children under 6 years.
Use in elderly patients
In the treatment of elderly patients a dose adjustment is required.
The use in patients with impaired renal function
When treating patients with impaired renal function dose adjustment is required.
The use in patients with impaired liver function
Although pharmacokinetic data in patients with hepatic insufficiency, no patients, such patients Imodium® Express should be used with caution due to the slow first-pass metabolism (see. “Special Instructions” section).
DIRECTIONS FOR USE
Since the freeze-dried tablet is quite fragile, to avoid damaging them should not push through the foil.
In order to get the pill from the blister the following steps: – Take the edge of the foil and completely remove it from the cell in which the tablet; – Gently press the bottom and remove the tablet from the packaging.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

JOHNSON

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