Etoksidol tab Gesves. 100mg 20 pieces

$18.65

Etoksidol tab Gesves. 100mg 20 pieces

5 in stock

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SKU: 0516519494 Categories: , , Tags: ,

Description

Composition
Active substance:
1 tablet contains: ethylmethylhydroxypyridine malate (etoksidol) – 100 mg.
Excipients:
Atsetilglutaminovaya acid (N-acetyl-L-glutamic acid) – 68 mg, deanol (2-dimethylaminoethanol) – 32 mg, glycine – 20 mg Microcrystalline cellulose – 260.1 mg, povidone (Kollidon 90F) – 1,6 mg monohydrate lactose (milk sugar) – 36 mg pregelatinized starch (starch 1500) – 30 mg colloidal silicon dioxide (aerosil) – 9.5 mg magnesium stearate – 6 mg croscarmellose sodium (primelloza) – 12.8 mg of sodium cyclamate – 18 mg, orange flavoring (flavor food “orange”) – 6 mg.
Product form:
Chewable tablets of 100 mg. 10 tablets in blisters of PVC film and aluminum foil printed patent. 1, 2, 5 contour of cellular packages with instructions for use placed into packs of cardboard.
Contraindications
Hypersensitivity to the drug, lactose intolerance, lactase deficiency, glucose-galactose malabsorption. Acute hepatic and / or renal failure, pregnancy, lactation, age up to 18 years (effectiveness and safety have been established).
Dosage
100 mg
Indications
Coronary heart disease (in the complex therapy); complex therapy of ischemic stroke; encephalopathy; light and moderate cognitive impairment.
Interaction with other drugs
Enhances the action of antiepileptic drugs (carbamazepine), antiparkinsonian agents (levodopa) and benzodiazepine anxiolytics. Increases nitropreparatov antianginal activity and antihypertensive ACE inhibitors and beta-blockers. It reduces the toxic effects of ethanol.
Overdose
Due to the low toxicity of the drug overdose unlikely. Accidental overdose may cause symptoms of sleep disorders – drowsiness, insomnia.
Treatment is symptomatic.
pharmachologic effect
Pharmacological group:
Anti-oxidant agent.
Pharmacodynamics:
Etoksidol® is an inhibitor of free radical processes, has a membrane-protective, anti-hypoxic, nootropic, anticonvulsant, anxiolytic action, increases resistance to stress. Etoksidol® has anti-ischemic properties, improves blood flow in the ischemic area, limits the area of ​​ischemic damage detects hypolipidemic effect, reduces total cholesterol and low density lipoproteins. The preparation increases the body’s resistance to the damaging effects of various factors, kislorodzavisimym pathological conditions (shock, hypoxia and ischemia, cerebrovascular accident, alcohol intoxication and antipsychotic agents (neuroleptics)). Preparation improves cerebral metabolism and cerebral blood flow, improve microcirculation and blood rheology, reduce platelet aggregation. It stabilizes the membrane structure of blood cells (erythrocytes and platelets) for hemolysis. The mechanism of action of the drug due to its antioxidant, antihypoxic and membrane action. It inhibits lipid peroxidation, increases the activity superoksidoksidazy, increases the ratio of lipid-protein membrane reduces viscosity and increases its fluidity. Modulates the activity of membrane enzymes (calcium independent phosphodiesterase, adenylate cyclase, acetylcholinesterase) receptor complexes (benzodiazepine, GABA, acetylcholine) that enhances their ability to bind to ligands, promotes preservation of structural and functional organization of biological membranes, transport of neurotransmitters and improve synaptic transmission.
Pharmacokinetics:
After oral administration, rapidly and completely absorbed from the gastrointestinal tract with a mean speed of 0.569 ± 0.086 hr-1. In healthy volunteers revealed that in oral administration Etoksidol® tablets 100mg maximum concentration (C max) in blood plasma obtained 0.28 ± 0.08 hours and was 487.0 ± 72.4 ng / ml followed by rapid Withdrawal eventually half-life (T 1/2) = 1,46 ± 0,13 h. Etoksidol® rapidly distributed to organs and tissues of the body. Determined in the blood plasma for 7-10 hours. The drug is extensively metabolized in the liver to form the phosphate-3-hydroxypyridine, glyukuronokonyugirovannyh products.
Pregnancy and breast-feeding
Etoksidol® contraindicated during pregnancy and lactation, as well-controlled clinical studies safety of the drug during pregnancy and lactation was conducted.
Conditions of supply of pharmacies
On prescription.
side effects
Usually the drug is well tolerated. In rare cases may cause allergic reactions, dyspeptic disorders, nausea and dry mouth, diarrhea, which quickly disappear on their own, or to remove the drug. With prolonged use may be a manifestation of flatulence, sleep disturbances (drowsiness or disturbance of sleep).
special instructions
During the period of treatment must be careful when driving and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Storage conditions
In a dry, protected from light at a temperature not higher than 25 C. Keep out of reach of children.
Dosing and Administration
Etoksidol® Tablets appointed interior. Tablets chew and washed down with water.
For the treatment of coronary heart disease and ischemic stroke therapy administered 100 mg (1 tablet) 3 times a day, gradually increasing the dose until a therapeutic effect. The maximum single dose – 200 mg; daily – 800 mg. Course – not less than 2 months, repeated courses – on doctor’s advice. The duration of treatment and the selection of individual dose depends on the severity of the patient’s condition and treatment.
In treatment of mild to moderate cognitive disorders, drug is given without limiting the duration of course of treatment in a dose of 100 mg 3-4 times a day.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

RERUMFARM

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