Etoksidol injection 50mg / ml 2 ml 10 units


Etoksidol injection 50mg / ml 2 ml 10 units



Active substance:
1 ml contains: ethylmethylhydroxypyridine malate (etoksidol) – 50 mg.
Acid N-acetyl-L-glutamic – 34 mg, deanol (2- (dimethylamino) ethanol) – 16 mg, glycine – 0.1 mg disodium edetate (disodium salt of ethylenediamine-N, N, N ‘, N’-tetraacetic acid 2-water [Trilon B]) – 0.5 mg water for injection – up to 1.0 ml.
Product form:
Solution for intravenous and intramuscular administration of 50 mg / ml. 2 ml or 5 ml in neutral glass ampoules mark NA NA-1 or-3 or lighting glass SNS-1 or SNS-3. 10 vials were placed in a box made of cardboard. 5 ampoules were placed in blisters of PVC film and aluminum foil printed lacquered or without foil. 2 blisters were placed in a pile of cardboard. In each pack, the box put the instructions for use, scarifier ampoule. When using ampoules with a ring or a break-point and notched scarifier ampoule not invest.
Increased sensitivity to the drug or its components. Pregnancy, lactation, age under 18 years old.
50 mg / ml
Acute ischemic attacks; encephalopathy; autonomic dystonia syndrome; mild cognitive disorders of atherosclerotic; anxiety disorders in neurotic and neurosis-like states; relief of abstinence syndrome in alcoholism with prevalence of neurosis and vegetative-vascular disorders; acute intoxication antipsychotics ;.
Interaction with other drugs
Potentiates the effect of benzodiazepine anxiolytics, anticonvulsants (carbamazepine), antiparkinsonian agents (levodopa). It reduces the toxic effects of ethanol.
Symptoms: sleep disorders (insomnia, drowsiness in some cases); when administered intravenously – slight and short-term (1.5-2 hr) increasing blood pressure.
Treatment: as a rule, does not require – the symptoms disappear on their own within a day. In severe cases, insomnia – 10 mg of nitrazepam, oxazepam 10 mg or 5 mg diazepam. When excessive increase in blood pressure – antihypertensive medications under the control of blood pressure.
pharmachologic effect
Pharmacological group:
Anti-oxidant agent.
Etoksidol is an inhibitor of free radical processes, has a membrane-protective, anti-hypoxic, nootropic, anticonvulsant, anxiolytic action, increases resistance to stress. Etoksidol has anti-ischemic properties, improves blood flow in the ischemic area, limits the area of ​​ischemic damage detects hypolipidemic effect, reduces total cholesterol and low density lipoproteins. The preparation increases the body’s resistance to the damaging effects of various factors, kislorodzavisimym pathological conditions (shock, hypoxia and ischemia, cerebrovascular accident, alcohol intoxication and antipsychotic agents (neuroleptics)). Preparation improves cerebral metabolism and cerebral blood flow, improve microcirculation and blood rheology, reduce platelet aggregation. It stabilizes the membrane structure of blood cells (erythrocytes and platelets) for hemolysis. The mechanism of action of the drug due to its antioxidant, antihypoxic and membrane action. It inhibits lipid peroxidation, increases the activity superoksidoksidazy, increases the ratio of lipid-protein membrane reduces viscosity and increases its fluidity. Modulates the activity of membrane enzymes (calcium independent phosphodiesterase, adenylate cyclase, acetylcholinesterase) receptor complexes (benzodiazepine, GABA, acetylcholine) that enhances their ability to bind to ligands, promotes preservation of structural and functional organization of biological membranes, transport of neurotransmitters and improve synaptic transmission.
In intramuscular formulation is determined in plasma during the 4 hours after administration. The time to reach maximum concentration was 0.25 hours. The maximum concentration at a dose of 100 mg – 0,3-1,06 g / ml. Etoksidol moves quickly from the bloodstream to organs and tissues and is rapidly eliminated from the body. The retention time of the drug (MRT) is 1,84-2,38 hours. half-life is 1,15-1,75 hours. Etoksidol excreted by the kidneys, mainly in glyukuronokonyugirovannoy form and in small quantities unchanged.
Pregnancy and breast-feeding
Etoksidol is contraindicated in pregnancy and lactation, as well-controlled clinical studies safety of the drug during pregnancy and lactation was conducted.
Conditions of supply of pharmacies
On prescription.
side effects
Dryness, “metallic” aftertaste in the mouth, sensation “pourable heat” in the body, odor, sore throat, discomfort in the chest, feeling of lack of air (usually associated with excessively high administration rate and are of short duration); long-term use – nausea, flatulence; sleep disturbances (drowsiness or disturbance of sleep).
special instructions
During the period of treatment must be careful when driving and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Storage conditions
In the dark place at a temperature not higher than 25 ° C. Keep out of the reach of children.
Dosing and Administration
Etoksidol administered intramuscularly and intravenously (bolus or infusion). When the infusion method of administering the drug should be diluted in 0.9% sodium chloride solution. Doses are selected individually.
Begin therapy at a dose of 50-100 mg, 1-3 times a day, gradually increasing to produce a therapeutic effect. Chip Etoksidol introduced slowly over 5-7 minutes, dropwise – at a rate of 40-60 drops per minute. The maximum daily dose should not exceed 800 mg.
In acute cerebrovascular disorders Etoksidol administered in combination therapy for the first 2-4 days intravenously (drip) at a dose of 200-300 mg, followed by intramuscular injection of 100 mg 3 times a day. The duration of treatment 10-14 days.
In vascular encephalopathy in phase decompensation etoksidol administered intravenous bolus or infusion in a dose of 100 mg 2-3 times a day for 14 days. Then – intramuscular injection of 100 mg 2 times a day for 14 days. For ESP preventing vascular encephalopathy preparation is administered intramuscularly at a dose of 100 mg 2 times a day for 10-14 days.
For mild cognitive impairment in elderly patients and in anxiety disorders, drug use by intramuscular injection at a daily dose of 100-300 mg / day for 14-30 days.
When alcohol withdrawal syndrome etoksidol administered intramuscularly in the dose of 100-200 mg 2-3 times a day or intravenously 1-2 times a day for 5-7 days.
In acute intoxication antipsychotics preparation is administered intravenously at a dose of 50-300 mg per day for 7-14 days.
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg


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