Estrokad suppositories vaginas. 0.5mg 10 pc

$13.48

Estrokad suppositories vaginas. 0.5mg 10 pc

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Description

Composition
Active substance:
1 suppository contains: 0.5 mg of estriol
Excipients:
solid fat, macrogol cetostearyl ether, glycerol monodiritsinoleat.
Description:
Suppositories are white or almost white, odorless.
Product form:
Vaginal suppositories 0.5 mg.
Packing 10 pcs.
Contraindications
Pregnancy and lactation. Established with a history of or suspected breast cancer. Established or suspected estrogen-dependent cancers (e.g., endometrial cancer). Vaginal bleeding is uncertain etiology. Untreated endometrial hyperplasia. Thrombosis, embolism. Liver disease in the acute phase of liver disease or a history of, after which no liver function returned to normal. Installed sensitivity to the active agent or any of the excipients. Porphyria.
Carefully
Endometriosis or leiomyoma, thromboembolism history or risk factors of its development, the risk factors of estrogen dependent tumors, including 1 tbsp. breast cancer, hypertension, liver disease (including adenoma), diabetes mellitus with or without involvement of the blood vessels, cholelithiasis, or severe migraine headache, SLE, a history of endometrial hyperplasia, epilepsy, asthma, otosclerosis.
Dosage
0.5 mg
Indications
Hormone replacement therapy for the treatment of atrophy of the mucosa of the lower genital tract caused by estrogen deficiency (dyspareunia, vaginal dryness, pruritus, urinary frequency, mild urinary incontinence);
Pre- and post-operative therapy in postmenopausal women, who will be held or vaginal access operation. For diagnostic purposes in unclear results of vaginal smear on the background of atrophic changes.
Interaction with other drugs
The drug can increase the effects of steroids, so you need to adjust the dosage of the latter.
While the use of activated charcoal, barbiturates, hydantoin derivatives, and rifampin may decrease activity estriol.
Estriol may alter the effectiveness of oral anticoagulants, while the use of estriol with beta-blockers and insulin increases the effectiveness of the latter.
Overdose
When intravaginal application overdose is unlikely
Symptoms (in case of accidental ingestion): nausea, vomiting, bleeding, “cancel”.
Treatment is symptomatic. No specific antidote.
pharmachologic effect
Pharmacological group:
Hormones of sexual glands and the preparations, used for the pathology of the sexual sphere. Estrogens.
Pharmacodynamics:
Estrogen, which is synthesized in the human body. Once in the bloodstream, is complexed with specific receptors (in the uterus, vagina, urethra, mammary gland, liver, hypothalamus, pituitary), stimulates the synthesis of DNA and proteins. Has a selective action, mostly on the cervix, vagina, vulva, causes increased proliferation of the vaginal epithelium and cervical stimulates its blood supply, contributes to the restoration of the epithelium when atrophic changes in premenopausal and menopausal normalizes pH of the vaginal environment, the microflora of the vagina and increases its resistance epithelium to infectious and inflammatory processes that affect the quality and quantity of cervical mucus. Effects on the endometrium slightly (a slight risk of uterine bleeding). It has hypolipidemic action slightly increases the blood concentration of beta-lipoprotein, increases sensitivity to insulin action, improves glucose utilization, stimulates liver binding globulin sex hormone, renin, HDL and blood clotting factors. By participating in the implementation of the positive and negative feedback to the hypothalamic-pituitary-ovarian estradiol system can cause moderately pronounced central effects, stimulates parasympathomimetics reaction.
Pharmacokinetics:
TCmax in intravaginal application -. 1.2 h Excretion is mainly kidneys as metabolites (a few hours after administration and continuing up to 18 hours), 2% is excreted through intestine unchanged.
Pregnancy and breast-feeding
When pregnancy is contraindicated. Estriol is excreted in breast milk, so the period of treatment should stop breastfeeding.
Conditions of supply of pharmacies
Without recipe.
side effects
Possible tension, swelling or pain in the breast, fluid retention, nausea, hypersecretion of cervical mucus, hypertension, muscle cramps, headache, blurred vision, spots on the skin.
special instructions
With long-term estrogen therapy indicated for systematic medical examinations.
Before the start of the reception and every 6 months of treatment should be thorough general medical and gynecological examination, including the study of mammary glands.
Storage conditions
Keep out of reach of children, dry, dark place at a temperature not higher than 25 C.
Dosing and Administration
Apply intravaginally adult women.
When mucosal atrophy of the lower genital tract – 0.5 mg (1 suppositories) per day every day for 3 weeks with a gradual reduction to maintenance dosage, which is 0.5 mg (1 suppository), 2 times per week.
When pre – and post-operative treatment of post-menopausal women with vaginal access operations – 0.5 mg (1 suppository) a day every day for 2 weeks before surgery, 0.5 mg (1 suppository) twice a week for 2 weeks after surgery .
As an auxiliary diagnostic agent: 0.5 mg (1 suppository) every other day for a week before taking the next stroke.
If another dose has been missed, it should be taken immediately after revealing the fact of crossing. However, if this fact was discovered only on the day of the next dose of the drug should continue its application in the usual way, in spite of the omission. Do not take 2 doses on the same day.
To prevent proliferation of endometrial daily dose should not exceed 0.5 mg (1 suppository). Do not use the maximum dosage for more than 4 weeks.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

ATSINO RUS

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