Enerion tab n / about 60 pcs 200mg

Description

Composition Active ingredient: sulbutiamine 200.0 mg. Excipients: 12.0 mg corn starch, dried starch paste 40.0 mg, glucose (dextrose), anhydrous 20.0 mg Lactose monohydrate 65.5 mg Magnesium stearate 3.50 mg Talc 9.00 mg; shell composition: Sodium bicarbonate 0.603 mg, carmellose sodium 0.556 mg, wax white beeswax 0.201 mg, titanium dioxide (E171) 8,430 mg Ethylcellulose 0.485 mg, colorant sunset yellow FCF (E110) 3,000 mg, of glycerol monooleate 0.242 mg, Polysorbate 80 0.302 mg povidone K-30 0.692 mg sucrose 106.956 mg anhydrous colloidal silica (Aerosil 130®) 0,404 mg talc 28.210 mg. Description: Round, biconvex film-coated tablets, orange. Slight surface heterogeneity (degree of gloss), and slight staining of inclusions. Product: Film-coated tablets, 200 mg. 10 tablets in a blister (PVC / Al). 2 blisters with instruction for use in a cardboard box. 15 tablets in a blister (PVC / Al). 2 and 4 blisters with instruction for use in a cardboard box. Contraindications Persons under 18 years of age is contraindicated due to the lack of clinical data. Hypersensitivity to the active substance (sulbutiamine) or any of the components. Lactase deficiency, galactosemia, the glucose / galactose malabsorption syndrome, sucrose-izomaltaznaya insufficiency, fructose intolerance (see. The section “Special instructions”) in consequence of the content in a formulation consisting of auxiliary substances glucose, lactose and sucrose. Pregnancy and breast-feeding. With caution in drug composition includes a colorant sunset FCF (A110). It can cause allergic reactions (see. Section “Special Instructions” and “Side effects”). Dosage 200 mg Indications overstrain states in adults, accompanied by fatigue, reduced efficiency, weakness. Interaction with other drugs Clinical studies of sulbutiamine interactions with other drugs was conducted. Interactions which should be taken into account: This preparation is blocking neuromuscular transmission (muscle relaxants): the effect of these drugs may increase while taking a thiamine (a metabolite mulbutiamina); Diuretics: increased urinary excretion of thiamine (metabolite sulbutiamine). Overdose Cases sulbutiamine overdose has been reported. Possible symptoms: excitement with euphoria phenomena and tremor of limbs, which are transient and require special treatment. In case of overdose should immediately consult a doctor. Treatment: symptomatic. The drugs Group: Means, which regulate metabolic processes in the central nervous system. Pharmacodynamics: sulbutiamine original compound is obtained by a series of thiamine structural modifications thiamine core: disulfide bond formation, the introduction of the lipophilic ester and the opening of the thiazole ring. Due to this modification, sulbutiamine: o It is soluble in fats, which allows it to be rapidly absorbed from the gastrointestinal tract and readily penetrate the blood-brain barrier; o Is able to accumulate in the cells of the reticular formation, dentate gyrus and hippocampus, Purkinje cells and glomeruli and granular layer of the cerebellar cortex as evidenced by histochemical analysis. In the placebo-controlled studies in humans, as well as in studies with active controls found evidence of drug efficacy Enerion® the symptomatic treatment of functional asthenia. Sulbutiamine metabolized to thiamine (vitamin B1). In a complex with adenosine triphosphate (ATP) forms of thiamin, thiamine diphosphate (carboxylase or thiamine pyrophosphate), which as a coenzyme is involved in carbohydrate metabolism. Pharmacokinetics Sulbotiamin rapidly absorbed, sulbutiamine plasma concentration peaks (Cmax) in 1-2 hours after administration. Subsequently sulbutiamine blood concentration decreases exponentially. Sulbutiamine rapidly distributed in the body, in this case a large extent gets to the brain, which has been demonstrated in animal experiments. The half-life (T1 / 2) – about 5 hours. Sulbutiamine excreted in the urine. Cmax observed in the urine after 2-3 hours after ingestion. Pregnancy and lactation Data on the use of sulbutiamine in women during pregnancy is limited. As a precaution, the use during pregnancy and breast-feeding is contraindicated. Conditions of supply of pharmacies without a prescription. Adverse events The frequency of side effects that may occur during therapy, is shown by the following grading: very often (> 1/10); common (> 1/100, Specific guidance composition formulation auxiliaries include glucose, lactose and sucrose. Because of this, the drug is contraindicated for use in patients with lactase deficiency, galactosemia, a syndrome glucose / galactose malabsorption, Sucrose-izomaltaznoy insufficiency, fructose intolerance. The drug composition includes a colorant sunset FCF (E110). It can cause allergic reactions (see. Section “Side effects”). Distortion of results of laboratory tests. The drug is metabolized to thiamine that can affect the test results: Determination of uric acid, phosphotungstic method: the drug can cause false positive results; Analysis of urine on urobilinogen with Ehrlich’s reagent: may give false positive results. Thiamine in high doses may affect the spectrophotometric determination of theophylline in serum by the method of the Shack and Waxler. Effects on ability to drive and perform the work requires a high rate of psychomotor reactions should be careful when driving and performing tasks that require a high rate of psychomotor reactions taking into account the possible development of adverse reactions. Storage conditions at a temperature no higher than 25 ° C. Keep out of the reach of children. Dosing and dose inside. For adults only. The daily dose is 2-3 tablets (400 – 600 mg) in two stages (during breakfast and dinner): 1 tablet during breakfast and one tablet at lunch time, or one tablet at lunch time and 2 tablets during lunch, or 2 tablets during breakfast and 2 tablets during dinner. The tablets should be swallowed whole with water. The treatment duration should not exceed 4 weeks. Do not exceed the recommended dose and duration of administration of the drug. If your condition has worsened or did not improve after 4 weeks, you should consult your doctor. Info appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist