Elmutsin caps. 300mg 20 pieces Obolensky

Description

Composition
Active substance:
erdosteine ​​300mg;
Excipients:
Microcrystalline cellulose 13.0 mg Povidone K30 8.0 mg Magnesium stearate 3.0 mg;
hard gelatin capsules: a body and a capsule cap – 1.3333% titanium dioxide, dye 0.9197% quinoline yellow, sunset yellow dye 0.0044% gelatin – up to 100%.
Description:
№1 hard gelatin capsules with the body and cap are yellow. Contents of capsules – powder white or nearly white.
Product form:
Capsules 300 mg.
20 capsules in blisters of PVC film and aluminum foil printed patent, together with instructions for use placed in a pile of cardboard.
Contraindications
Hypersensitivity to the components included in the preparation.
Children up to age 18 years.
Abnormal liver function.
Renal insufficiency.
Gomotsisteinuriya (the drug is a source of homocysteine, so there may be disturbances of amino acid metabolism in patients who are on a diet with a reduced content of free methionine).
Pregnancy (I term).
During breastfeeding.
Carefully
The drug should be used with caution in patients with expressed human liver; in diseases of the bronchi, soprovodayuschihsya excessive accumulation of secretions.
Dosage
300 mg
Indications
respiratory diseases to form a viscous mucus (in combination therapy)
Interaction with other drugs
With simultaneous use of erdosteine ​​increases the concentration of amoxicillin in the bronchial secretion, which allows for more rapid response to therapy versus monotherapy with amoxicillin.
Overdose
No cases of overdose have been reported. However, in cases of overdose or accidental use of children, it is recommended gastric lavage and symptomatic therapy.
pharmachologic effect
Pharmacological group:
Expectorant mucolytic agent
Pharmacodynamics:
Efficacy erdosteine ​​due to the action of the active metabolites. Thiol groups metabolites cause rupture disulfide bridges that connect one with the other fibers glycoproteins, which reduces the elasticity and viscosity of sputum. As a result, erdosteine ​​augments and accelerates the release of respiratory tract secretions, epithelial secretory function improves and increases the efficiency of the mucociliary transport in upper and lower regions of the respiratory tract.
Erdosteine ​​has an antioxidant effect and transports free radicals. In particular erdosteine ​​protects the airways from the damaging effects of cigarette smoke against the inactivation of alpha-1-antitrypsin.
Erdosteine ​​increases the concentration of immunoglobulin A (IgA) airways in patients with chronic obstructive airway diseases in mucosa, and also reduces the inhibitory effect of cigarette smoke on granulocyte function.
The effect of the therapy erdosteine ​​develops 3-4 days of treatment. Erdosteine ​​as such does not contain free SH-radicals thus has no damaging effect on the gastrointestinal tract and the side effects of the digestive system does not differ from placebo effects.
Pharmacokinetics:
Erdosteine ​​rapidly absorbed from the gastrointestinal tract and metabolized in the liver to active metabolites of the three most important of which – N-thiodiglycol-homocysteine ​​(metabolite 1 or M1). The half-life (T1 / 2) is more than 5 hours. Reapply erdosteine ​​or food intake does not affect the pharmacokinetic parameters. The maximum concentration (Cmax) in plasma was 3.46 micrograms / ml, the time to reach maximum concentration (Tmax) – 1.48 hours, area under the curve “concentration-time” (AUC0-24ch) – 12.09.
Erdosteine ​​binds to plasma proteins by 64.5%. Excreted as inorganic sulfates through the kidneys and intestines.
In the case of liver function abnormalities marked increase in performance: maximum concentration (Cmax) and area under “concentration-time” curve (AUC).
May increase the half-life (T1 / 2) when expressed abnormal liver function.
In renal insufficiency possible accumulation of metabolites.
Pregnancy and breast-feeding
Preclinical studies have shown no embryotoxicity erdosteine ​​action. Experience erdosteine ​​use during pregnancy and lactation is limited. Therefore, use of the drug can only be prescribed by a doctor in the II and III trimester of pregnancy, if the expected benefit to the mother outweighs the potential risk to the fetus.
Conditions of supply of pharmacies
Without a prescription.
side effects
The frequency of adverse reactions is presented according to WHO classification: very often (> 1/10 cases), often (> 1/100 and
special instructions
If treatment is necessary to take a sufficient amount of fluid, which increases the expectorant effect. In cases of dysmotility bronchi or a significant amount of allocated sputum drug application requires caution, because of the risk of delay in the discharge of the airways and increased risk of infection or bronchospasm accession.
The effect on the ability to operate vehicles, machinery
It does not affect the ability to drive vehicles, mechanisms and engage in other activities that require high concentration and psychomotor speed reactions.
Storage conditions
At a temperature of not higher than 25 degrees.
Keep out of the reach of children.
Dosing and Administration
1 capsule (300 mg), 2 times per day.
If there is no improvement within 5 days after the onset of the drug or if deterioration occurs, you should contact your doctor.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist