Ekzoderil cream 1% 30g tube

Description

Composition
Active substance:
1 g of cream contains: naftifine hydrochloride – 10.0 mg.
Excipients:
Hydroxide – 1.2 mg benzyl alcohol – 10.0 mg Sorbitan Stearate – 19.0 mg, cetyl palmitate – 20.0 mg Cetyl alcohol – 40.0 mg, stearyl alcohol – 40.0 mg polysorbate 60 – 61 0 mg, isopropyl – 80.0 mg purified water – 718.8 mg.
Description:
White, uniform or slightly grainy, shiny cream with a weak characteristic odor.
Product form:
Cream for external application of 1%. 15 or 30 g of cream in an aluminum tube. 1 tube together with instructions for use in a cardboard package.
Contraindications
Hypersensitivity to naftifine, benzyl alcohol or other components of the formulation; pregnancy and lactation (safety and efficacy have not been determined).
Precautions: children’s age (clinical application experience is limited).
Dosage
1 %
Indications
Fungal infections of skin and skin folds (tinea corporis, tinea inguinalis), including interdigital mycosis (tinea manum, tinea pedum); Nail fungal infections (mycoses oniho-); Skin candidiasis; chromophytosis; dermatomycosis (with or without itching accompanying it).
Interaction with other drugs
There was no interaction with other drugs.
Overdose
No cases of overdose have been reported.
pharmachologic effect
Pharmacological group:
Antifungal agent.
Pharmacodynamics:
Naftifine – antifungal agent for external use, referring to the class of allylamine. The mechanism of action is associated with inhibition of squalene epoxidase -2,3 that reduces the formation of ergosterol, a component of fungal cell walls. Active against dermatophytes such as Trichophyton, and epidermofiton mikrosporum, molds (Aspergillus spp.), Yeast (Candida spp., Pityrosporum) and other fungi (e.g., Sporothrix schenckii).
In against dermatophytes and Aspergillus acts fungicidally naftifine. With respect to the preparation of yeasts exhibits fungicidal or fungistatic activity depending on the microorganism strain. It possesses antibacterial activity against Gram-positive and Gram-negative microorganisms that can cause secondary bacterial infection. It has anti-inflammatory action, which contributes to the rapid disappearance of the symptoms of inflammation, especially pruritus.
Pharmacokinetics:
When applied topically penetrates well into different layers of the skin, creating a stable antifungal concentrations of its various layers. After application to the skin is exposed to systemic absorption less than 6% naftifine. Quantity sucked partially metabolized and excreted through the intestines and kidneys. The half-life is 2 – 3 days.
Conditions of supply of pharmacies
Without recipe.
side effects
In some cases, local reactions can occur: dry skin, skin redness and burning. Side effects are reversible and do not require discontinuation of treatment.
special instructions
Precautions for use:
Ekzoderil® The drug is not intended for use in ophthalmology. Do not allow contact with the drug in the eye.
Effect on the ability to drive, etc. mechanisms:. Ekzoderil® not adversely affect the ability to drive, and perform other activity such require concentration and psychomotor speed reactions.
Storage conditions
At a temperature of not higher than 30 C.
Keep out of the reach of children!.
Dosing and Administration
Outwardly.
When skin lesions Ekzoderil® applied 1 time a day to the affected skin surface and its neighboring areas (approximately 1 cm of a healthy area of ​​skin around the edges of the affected area) after their thorough cleaning and drying. The duration of therapy with dermatomycosis – 2-4 weeks (if necessary – up to 8 weeks) at candidiasis – 4 weeks.
With the defeat of Ekzoderil® polish is applied 2 times a day to the affected nail. Before the first use of the drug was removed as much as possible the affected part of the nail clippers or nail file. The duration of therapy for onychomycosis – up to 6 months. To prevent relapse, treatment should continue for at least 2 weeks after the disappearance of clinical symptoms.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist