Drotaverinum tab 40mg 20 units Ozone

$1.56

Drotaverinum tab 40mg 20 units Ozone

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SKU: 20240972 Categories: , , Tag:

Description

Composition
Active substance:
1 tablet contains: drotaverine hydrochloride 40.00 mg 80.00 mg.
Product form:
Tablets 40.0 mg, 80.0 mg. 10, 14, 25, 30, 50 tablets in blisters of PVC film and aluminum foil printed patent. 10, 20, 30, 40, 50 or 100 tablets in cans or in cans PET polymer for medicaments. One jar or 1, 2, 3, 4, 5 or 10 contour cell packages together with instructions for use placed in a cardboard box (pack).
Contraindications
– Increased sensitivity to drotaverine and / or auxiliary substances forming part of the formulation; – severe hepatic or renal failure; -heavy heart failure (low cardiac output syndrome); – the period of breast-feeding; – Children’s age (up to 6 years); – hereditary lactose intolerance, lactase deficiency or malabsorption syndrome glucose / galactose.
Dosage
40 mg
Indications
– Spasm of smooth muscle in diseases of the biliary tract: cholecystolithiasis, cholangiolithiasis, cholecystitis, pericholecystitis, cholangitis, an inflammation of duodenal papilla; – smooth muscle spasm urinary tract diseases: nephrolithiasis, uretrolitiaz, pyelitis, cystitis, bladder spasm; As an adjuvant therapy: – with spasms of smooth muscles of the gastrointestinal tract: gastric ulcer and duodenal ulcer, gastritis, spasm cardia, and pylorus, enteritis, colitis, spastic colitis, constipation and irritable bowel syndrome with bloating after exclusion of diseases manifested syndrome ” acute abdomen “(appendicitis, peritonitis, perforated ulcer, acute pancreatitis, etc.); – tension headaches; – dysmenorrhea.
pharmachologic effect
Pharmacological group:
Antispasmodic. ATC code A03AD02.
Pharmacological properties:
Drotaverine – isoquinoline derivative, the chemical structure and pharmacological properties close papaverine, but having a stronger and prolonged action. Drotaverine has potent antispasmodic effect on smooth muscle by inhibiting the enzyme phosphodiesterase (PDE). Phosphodiesterase enzyme necessary for the hydrolysis of cAMP (cyclic adenosine-3`, 5`-monophosphate) to AMP (adenosine monophosphate 5`). Inhibition of the enzyme phosphodiesterase increases the concentration of cAMP, which triggers the following cascade reaction: high concentrations of cAMP activates cAMP-dependent phosphorylation of myosin light chain kinase (MLCK). Phosphorylation MLCK leads to a decrease of its affinity to calcium ions – kalmodulinovomu complex, resulting in an inactivated form MLCK supports muscle relaxation. cAMP, in addition, effect on the cytosolic calcium ion concentration by stimulating the transport of calcium ion in the extracellular space and sarcoplasmic reticulum. This effect of drotaverine on the reduction of cytosolic calcium ion concentration through cAMP explains its antagonistic effect with respect to the calcium ion. In vitro drotaverin inhibits isozyme PDE4 isoenzymes without inhibiting PDE-3 and PDE-5. Therefore drotaverine efficiency depends on PDE-4 in the tissue concentrations, the content of which varies in different tissues. PDE4 is the most important to suppress the contractile activity of smooth muscle, in connection with which the selective inhibition of PDE 4 could be useful for the treatment of hyperkinetic dyskinesias and various diseases accompanied by spastic conditions of the gastrointestinal tract. Hydrolysis of cAMP in the myocardium and vascular smooth muscle occurs mainly via isoenzyme PDE 3, which explains the fact that at high spasmolytic activity in drotaverine no serious side effects of the heart and blood vessels and expressed effects on the cardiovascular system . Drotaverinum effective in spasms of smooth muscles of both neurogenic and muscular origin. Regardless of the type of the autonomic innervation of drotaverin relaxes the smooth muscles of the gastrointestinal tract, biliary tract, urinary tract, blood vessels. Due to its vasodilating action Drotaverinum improves blood circulation.
Conditions of supply of pharmacies
Without a prescription.
Dosing and Administration
Inside. Adults: 40 – 80 mg (1-2 tablets) 2-3 times a day. The maximum single dose – 80 mg, with a maximum daily dose – 240 mg. Children aged 6 to 12 years with a maximum daily dose of 80 mg, divided into 2 doses. Children older than 12 years – the maximum daily dose is 160 mg, divided into 2-4 doses. The recommended duration of treatment without consulting a doctor 1 -2 days.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

OZONE generics

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