Dorzopt drops Ch. 5ml 2%-cap vial. 3 pcs

Description

Composition
Active substance:
1 ml sodezhrit: dorzolamide hydrochloride based on dorzolamide 20.00 mg ;.
Excipients:
Gietilloza, mannitol, citric acid monohydrate, sodium hydroxide, benzalkonium chloride, purified water.
Description:
The clear, colorless solution.
Product form:
2% eye drops. 5 ml of solution in white polymeric bottle, equipped with a plug dropper and a closed polymeric cap with safety ring. 1 or 3 vials together with instructions for use in a cardboard package.
Contraindications
Hypersensitivity to any component of, chronic renal failure (creatinine clearance less than 30 mL / min), hyperchloremic acidosis; Children under 18 years of age, pregnancy, lactation, oral carbonic anhydrase inhibitors.
WITH CARE Diabetes mellitus, hepatic failure, corneal disease, patients after application antiglaukomatoznyh operations (risk of hypotension eye, retinal detachment).
Dosage
2%
Indications
Otkratougolnaya (including secondary) glaucoma; pseudoexfoliation glaucoma; ocular hypertension.
Interaction with other drugs
Antiglaucoma drugs (beta-blockers, pilocarpine, dipivefrin, carbachol) enhance the effect of dorzolamide. While the use of acetazolamide increased risk of systemic side effects. May increase the toxicity at high doses of acetylsalicylic acid.
Overdose
Symptoms: violation of water-electrolyte metabolism, acidosis, disorders of the central nervous system. Treatment: symptomatic therapy. It is necessary to control the levels of electrolytes (especially potassium) and pH level of the blood.
pharmachologic effect
Pharmacological group:
Carbonic anhydrase inhibitors.
Pharmacodynamics:
Antiglaucoma agents. Carbonic anhydrase inhibitors; It reduces the secretion of intraocular fluid, delaying the formation of hydrogen carbonate, followed by the weakening of the transport Na + and water. It does not cause accommodation spasm, cramps, night blindness.
Pharmacokinetics:
Preferably penetrates into the eye through the cornea (to a lesser extent through the sclera and limb). Systemic absorption – low. Once in the blood quickly into the red blood cells that contain a significant amount of carbonic anhydrase II. Relationship to plasma proteins – 33%. Transformed into N-dezetilirovanny metabolite is less active against carbonic anhydrase II, but able to block the carbonic anhydrase I. With prolonged use accumulates in erythrocytes. Excreted by the kidneys in unchanged form and as metabolites. After the cancellation of phase is replaced by rapid excretion slow due to the gradual release of the drug from the erythrocytes, with a half-life (T1 / 2) of about 4 months.
Conditions of supply of pharmacies
By prescription.
side effects
Local reactions: burning, crawling, itchy eyes, watery eyes, blurred vision, irritation and swelling of the eyelids, conjunctivitis, superficial punctate keratitis, blepharitis, photophobia; rarely – iridocyclitis, increasing the thickness of the cornea, allergic reactions, hypotension eye, retinal detachment in patients after antiglaukomatoznyh operations. Systemic reactions: bitterness in the mouth, nausea, headache, fatigue, nefrourolitiaz, malignant erythema multiforme (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome), agranulocytosis, aplastic anemia, skin rashes.
special instructions
The preservative benzalkonium chloride, contained in the product can be adsorbed soft contact lenses, causing eye irritation and toxic effects. The drug is used only after the removal of contact lenses. Wear contact lenses should be no earlier than 15 minutes after instillation. Necessary to monitor the content of potassium, serum electrolytes, and its pH. In old age may increase sensitivity to dorzolamide (required dose reduction). In the period of treatment must be careful when driving lesson other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Storage conditions
In a dry place, protected from light at a temperature not higher than 25 C.
In the reach of children.
Dosing and Administration
Buried 1 drop into the affected eye three times a day; in combination with beta-blockers for topical application – 1 drop of 2 times per day. If the treatment is applied by several local ophthalmic agents, their introduction should proceed at an interval of 10 minutes.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist