Dolon-MosFarma gel naruzhn.prim th 50g


Dolon-MosFarma gel naruzhn.prim th 50g


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Active substance:
Heparin sodium (Heparin sodium salt) – 50,000 IU (in terms of dry matter)
Dexpanthenol (D-Panthenol) – 2.50 g (converted to 100% dry matter)
Dimethylsulfoxide (dimexide) – 15.00 g (in terms of 100% substance).
Carbomer Homopolymer Type C – 1.00 g
Trometamol – 0.20 g
Macrogol glitserilgidroksistearat – 0.90 g
Ethanol (ethyl alcohol) 95% – 38.06 g
Rosemary oil – 0.20 g
Scots pine needle oil – 0.25 g
Lemon oil – 0.05 g
Purified water – up to 100.00 g
Colorless, clear or slightly opalescent homogeneous gel with a characteristic odor.
Product form:
Gel for external application. 30 g or 50 g aluminum tubes.
Each tube together with instructions for use placed in a pile of cardboard.
– hypersensitivity to one of the gel components (active / auxiliary substances); – severe dysfunction of the liver and / or kidney; – bronchial asthma; – The expressed disturbances of the cardiovascular system (IV angina functional class according to the classification of the Canadian Cardiovascular Society, myocardial infarction, stroke, expressed generalized atherosclerosis); – pregnancy, breast-feeding; – Children up to age 5 years.
Do not apply the drug on the mucous membranes (eyes, nose, mouth), open wounds or damaged skin (eg, post-exposure or severe sunburns, fresh postoperative scars).
500 IU + 25 mg + 150 mg / g
– swelling, bruising and inflammation of soft tissues, muscles, tendons, tendon sheaths and ligaments after injuries, pinched injuries; – contusions, bruises; – joint injuries with damage to the ligaments; – frozen shoulder and shoulder epicondylitis ( “tennis elbow”), tendonitis (tendon inflammation), tenosynovitis (inflammation of the tendon sheath), bursitis (inflammation of the lining of the joints bags); – acute neuralgia.
Interaction with other drugs
Topical administration of other drugs together with the drug-dolon MosFarma promotes a sharp increase in their permeability through the skin.
While the use of non-steroidal anti-inflammatory drug sulindac may develop peripheral neuropathy (due to the presence of the drug-dolon MosFarma dimethylsulfoxide).
Effects on ability to drive and busy with other potentially hazardous activities
Drug for cutaneous application does not affect the ability to drive vehicles and other classes of potentially hazardous activities that require high concentration and psychomotor speed reactions.
pharmachologic effect
Pharmacological group:
Anticoagulant means of direct action for local application + other drugs.
The action of the drug due to its constituent active agents: dimethyl sulfoxide, heparin sodium and dexpanthenol.
Dimethyl sulfoxide (DMSO).
DMSO has anti-inflammatory, anti-analgesic and local action.
Antiinflammatory activity is associated with some pharmacological effects, the most significant of which is the inactivation of hydroxyl radicals, are produced in large quantities during the process of inflammation and can have devastating effects on the tissue.
DMSO has a local analgesic effect by reducing the speed of the nociceptive (pain) pulses in peripheral neurons.
Antiedematous effect of hydroxyl radicals is provided by inactivation and improvement subcutaneous metabolic reaction at the site of the drug. To a certain extent, the hygroscopic properties of DMSO are also responsible for its antiedematous effect.
DMSO (50% or more) penetrates through biological membranes, including the skin, contributing to a better and deeper penetration into the tissue simultaneously applied to other drugs.
Heparin sodium.
Heparin sodium, part of the drug is the anticoagulant direct action; due to inactivation of biogenic amines in tissue exhibits a distinct anti-inflammatory effect, improving local circulation. Sodium Heparin inhibits the action of hyaluronidase, and thereby effectively contributes to the regeneration of connective tissue.
Sodium Heparin exhibits a dose-dependent antithrombotic effect, enhancing inhibitory activity of antithrombin III activation of prothrombin and thrombin. Penetration of sodium heparin through the intact skin is dose dependent and is supported for dosages ranging from 300 IU / g.
Dexpanthenol exhibits anti-inflammatory and dermatoprotektornoe effect, it stimulates regeneration processes. After absorption is transformed into pantothenic acid, which is involved in numerous metabolic processes, being part of co-enzyme A; by improving the processes of granulation and epithelialization promotes regeneration of damaged skin.
Dimethyl sulfoxide (DMSO).
DMSO enters the systemic circulation, poluabsorbtsii period of 3 – 4 h half-life of plasma – 11 -. 14 hours DMSO penetrates into breast milk. Advantageously eliminated with the urine.
After 6 hours after application of the preparation the maximum concentration in plasma is 120 ng / ml and maintained until 12 hours after application. After 60 hours of applying DMSO concentration in blood plasma reaches the physiological level of 40 ng / ml. 12 – 25% DMSO absorbed is excreted within the first 24 hours, and 37 – 48% output for 7 days in an unmodified form through the kidneys or in the form of a metabolite (dimethyl sulfone). 3.5 – 6.0% DMSO only outputted via the lungs as dimethylsulfide, after 6 – 12 hours after drug application.
When applied to 1 g of DMSO, 3 times a day for 5 days, its average content in the site of application on the skin of 3 mg / g, the average content in the underlying muscle tissue and the synovial membrane in place synovial joint 7 – 10 mcg / ml, in the synovial fluid – 0.8 g / g. The DMSO concentration in plasma was 0.5 mg / g.
The half-life of DMSO is 11 – 14 hours.
Heparin sodium.
Heparin sodium penetrates quickly into the skin; already during the first hours after application of the gel concentration in tissues subject to appropriate concentrations that would be achieved after / in the 5000 IU heparin. Sodium Heparin does not penetrate through the placental barrier and enters into breast milk.
For exterior use dexpanthenol in skin is transformed into pantothenic acid, in which the rate and extent of transdermal penetration of less than dexpanthenol.
Pregnancy and breast-feeding
Use during pregnancy
As the research data on the drug no pregnant women, its use in pregnancy is contraindicated.
Use during breastfeeding
Dimethyl sulfoxide passes into breast milk, so during treatment should stop breastfeeding.
Conditions of supply of pharmacies
Without a prescription.
side effects
The drug is generally well tolerated, but in rare cases, possible local skin reaction (redness, itching and burning sensation at the site of application), which usually disappear gradually in the treatment process.
Sometimes, because of the content of DMSO or other components of the preparation, may cause the total cutaneous allergic reaction with urticaria and angioedema.
In rare cases, during use this drug in some patients may receive the garlic odor of breath, due to the presence of dimethylsulfide – metabolite of dimethylsulfoxide. This smell indicates good absorbability of dimethyl sulfoxide. In some patients, after application of the gel may occur a change in taste, which disappears after a few minutes.
It is extremely rare when applying the drug on extensive areas of the body may cause nausea, diarrhea, shortness of breath, headache, chills.
special instructions
The drug is spent economically, quickly penetrates into the skin and leaves no greasy layer on the skin and spots on the underwear. Due containing alcohol (ethanol), which evaporates after application of the gel felt pleasant cooling of the site of application of the drug. The pleasant cooling effect is enhanced if the gel is stored in a refrigerator, or if the drug is used in hot weather (by increasing evaporation of alcohol).
Area of ​​skin to which the drug is applied, must be cleaned of dirt, cosmetics, pharmaceuticals and other chemicals.
When using dressings needed after application of the gel to wait a few minutes to suck the bulk gel and ethyl alcohol (ethanol) is evaporated. This is especially important in cases where the patch is applied, poorly permeable to air. At the time of treatment may be exacerbated skin sensitivity, so the period of its use should be restricted to intensive sunbathing and solarium.
In case of skin reaction, treatment should be discontinued.
Due to the high absorption of dimethyl sulfoxide must not be used dolon-MosFarma in combination with other ointments and gels.
It should be remembered that the ingress of the drug on open wounds causes pain response, since the gel comprises ethyl alcohol (ethanol).
Storage conditions
Store at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
The drug is applied in a thin layer on the skin surface over the area of ​​soft tissue, joints or tendons (edema, hematoma, inflammation, trauma), and uniformly distribute light rubbing movements.
In order to cover the entire surface of a bruised knee, is usually enough to squeeze from the tube 3 – 4 cm gel.
The procedure is repeated 2-4 times a day for 7 days or until the disappearance of such symptoms as pain, swelling, edema, inflammation.
If within 7 days of treatment does not occur a clear improvement, seek medical advice.
Upon application of the gel dressings with a breathable wound dressing is applied only after most of the penetration of the gel into the skin and evaporation of alcohol (a few minutes).
Dolon-MosFarma and iontophoresis. This preparation can be applied by iontophoresis. Contained in a preparation with sodium heparin solution is an anion. Application of the preparation under the cathode promotes increased penetration of sodium heparin in the affected area, and dimethylsulfoxide exhibits a synergistic effect with the effect of the electric current (analgesia, reduction of local edema).
Precautionary measures. It must be remembered that the treatment itself electric shock can cause local skin irritation response. Therefore, you must carefully follow the instructions by the manufacturer, to the use of the drug is not strengthened these local reactions.
You should always pay attention to the adequacy of coverage of the electrodes with a damp sponge.
Dolon-MosFarma and ultrasound (phonophoresis). This drug is a good contact with the gel ultrasound therapy (phonophoresis). The active ingredients of the gel (dimethylsulfoxide and sodium heparin) complements the therapeutic effect of ultrasonic waves.
overdose and poisoning the drug has not been described.
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg


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