Dolobene gel 45g tuba 2 pcs in one gift


Dolobene gel 45g tuba 2 pcs in one gift


SKU: 01897689841 Categories: , , Tags: ,


Active substance:
Sodium Heparin 50000 IU
Dexpanthenol 2.500 g
Dimethyl sulfoxide 90% 16.660 g (on dry basis) of (15.000 g)
Polyacrylic acid 1,000 – 1,400 g, Trometamol 0.200 – 0.300 g macrogol glitserilgidroksistearat (Cremophor CO 455) 1.000 g isopropanol 35.000 g, rosemary oil
0.200 g, mountain pine oil 0.250 g, 0.050 g citronella oil, purified water 42.023 – 42.913 g
from transparent to slightly cloudy and colorless to slightly yellow gel.
Product form:
3 tubes of 45 c.
– hypersensitivity to one of the gel components (active / excipients)
– bronchial asthma,
– severe liver, kidney,
– The expressed disturbances of the cardiovascular system,
– pregnancy and lactation,
– the age of 5 years,
– an open wound at the site of application.
– swelling, bruising and inflammation of soft tissues, muscles, tendons, tendon sheaths,
– contusions, bruises,
– joint injuries from sprained ligaments and tendons,
– shoulder epicondylitis ( “tennis elbow”), tendonitis (tendon inflammation), tenosynovitis (inflammation of the tendon sheath), bursitis (inflammation of the lining of the joint bags)
– periarthritis of shoulder joint,
– acute neuralgia.
Interaction with other drugs
Application of the other drug simultaneously with the preparation Dolobene may enhance their permeability across the skin. With the simultaneous use of the drug Dolobene and nonsteroidal anti-inflammatory drug Sulindac may develop peripheral neuropathy.
Data on overdose of the drug available.
pharmachologic effect
Pharmacological group:
anticoagulant means of direct action for local application + other drugs.
Dimethylsulfoxide (DMSO)
DMSO has anti-inflammatory, anti-edema and local anesthetic action.
Antiinflammatory activity is associated with some pharmacological effects, the most significant of which is the inactivation of hydroxyl radicals, are produced in large quantities during the process of inflammation and can have devastating effects on the tissue.
DMSO has a local analgesic effect by reducing the speed of the nociceptive (pain) pulses in peripheral neurons. Anti-edema effect of hydroxyl radicals is provided by inactivation and improvement subcutaneous metabolic reaction at the site of the drug. To a certain extent, the hygroscopic properties of DMSO are also responsible for its anti-edema effect.
DMSO (50% or more) penetrates through biological membranes, including the skin, contributing to a better and deeper penetration into the fabric used simultaneously with other medicines.
Heparin has anti-inflammatory action, promotes the regeneration of connective tissue due to inhibition of hyaluronidase activity.
Heparin exhibits a dose-dependent antithrombotic effect, amplifying the inhibitory activity of antithrombin III activation of prothrombin and thrombin.
Penetration through healthy skin heparin is dose dependent and is supported for dosages ranging from 300 IU / g.
When applied topically to the skin dexpanthenol transformed into pantothenic acid (vitamin B group). The efficacy is comparable with dexpanthenol pantothenic acid efficiency. Pantothenic acid is a component of coenzyme A is involved in a variety of catabolic and anabolic processes in tissues, by improving epithelization and granulation processes promotes regeneration of damaged skin.
Dimethylsulfoxide (DMSO)
Physiological concentration of DMSO in normal plasma is 40 ng / ml. After 6 hours after application of the preparation the maximum concentration in plasma is 120 ng / ml and maintained until 12 hours after application. After 60 hours of applying DMSO concentration in blood plasma reaches the physiological level of 40 ng / ml.
12-25% DMSO absorbed is excreted within the first 24 hours and 37-48% output for 7 days in an unmodified form through the kidneys or in the form of a metabolite (dimethyl sulfone).
3.5-6% of DMSO is output through the lungs in the form of dimethyl sulfide after 6-12 hours after applying the drug.
When applied to 1 g of dimethylsulfoxide, 3 times a day for 5 days, its average content in the site of application on the skin of 3 mg / g, the average content in the underlying muscle tissue and the synovial membrane in place synovial compound 7-10 mcg / ml, in the synovial fluid – 0.8 g / g. DMSO concentration in plasma was 0.5 mg / g.
DMSO half life is 11-14 hours.
When applied topically heparin absorbed slightly.
For exterior use dexpanthenol in skin is transformed into pantothenic acid.
Good absorption of dexpanthenol confirmed experimentally.
Pregnancy and breast-feeding
Use during pregnancy
As the research data on the use of the drug in pregnant women are missing,
its use during pregnancy is contraindicated.
Use during lactation
Dimethyl sulfoxide passes into breast milk, so during the use of the drug should stop breastfeeding.
Conditions of supply of pharmacies
Available without prescription.
side effects
Possible local skin reactions (redness, itching, burning sensation at the site of gel)
which usually disappear during the continued treatment.
Because the content of DMSO or other components of the drug sometimes may cause an allergic skin reaction.
In rare cases during use of the drug in some patients may appear the smell of garlic breath. The smell is caused by dimethyl sulfide, dimethyl sulfoxide is a product of metabolism.
You can change the taste, disappears after a few minutes after applying the gel.
In rare cases, may cause allergic reactions of immediate type (urticaria, angioneurotic edema).
It is extremely rare when applying the drug on extensive areas of the body may cause nausea, diarrhea, shortness of breath, headache, chills.
special instructions
Place the gel coating should be free of other drugs, cosmetics or any chemicals. Dolobene can not be applied to mucous membranes of the eyes, nose, mouth,
open wounds or damaged skin (due to exposure to strong sunlight burns, postoperative scars).
At the time of treatment may be exacerbated skin sensitivity, so the period of its use should be restricted to intensive sunbathing and solarium. IN
case of skin reactions treatment should be discontinued. Due to the high absorption of dimethylsulfoxide Dolobene not be used in combination with other ointments and gels.
Storage conditions
Store at a temperature not higher than 25 degrees.
Keep out of the reach of children!
Dosing and Administration
Dolobene surface layer should be applied to the skin above the affected area of ​​skin
2-4 times a day.
When using the gel under the bandage should apply the gel and wait for a few minutes so that it absorbed the skin and evaporate isopropanol. Then you can apply an airtight bandage.
Dolobene can be applied by iontophoresis. The preparation is applied under the cathode.
Dolobene as a coupling gel may be applied to ultrasonic therapy (phonophoresis).
Actives gel complement the therapeutic action of ultrasonic waves.
The duration of treatment depends on the severity of symptoms and disease severity.
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg


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