Differin gel 0.1% 30g tuba

Description

Composition
Active substance:
Adapalene – 1.0 mg.
Excipients:
Propylene glycol – 40.0 mg methyl parahydroxybenzoate – 1.0 mg phenoxyethanol – 2.5 mg Carbomer 940R – 11.0 mg disodium edetate – 1.0 mg Poloxamer 182 – 2.0 mg Sodium hydroxide – to pH 5.0 ± 0.15, purified water – up to 1 g
Description:
The gel is white.
Product form:
Gel for topical application of 0.1% to 30 grams of low density polyethylene tube, c tightly polypropylene screw cap. 1 tube together with instructions for use placed in a cardboard box.
Contraindications
– Increased sensitivity to adapalene or any of the excipients;
– Children under 12 years of age (efficacy and safety for this age group has not been established).
Dosage
0.1%
Indications
Acne mild to moderate severity, including the presence of comedones, papules and pustules.
Interaction with other drugs
Absorption through the skin adapalene is low, so its interaction with systemic medications is unlikely.
Not set of interactions with other drugs, which can be applied topically and simultaneously with the preparation Differin®. When applying a gel Differin® at night, in the morning may be employed such preparations for topical treatment of acne, erythromycin as solutions (up to 4%) or clindamycin phosphate (1% based on the base) or benzoyl peroxide gels on an aqueous basis (up to 10% ) because these drugs do not cause mutual degradation or cumulative irritation. However, at the same time should not use adapalene other retinoids or drugs with a similar mechanism of action.
Simultaneous use of the drug Differin® and means for peeling the abrasive cleansers, as well as with a drying means, astringent or irritant (aromatic or alcohol-containing means) is not recommended.
Overdose
Excessive application of the drug on the skin does not result in more rapid achievement results or obtaining a more pronounced effect, but it can develop redness, peeling or discomfort.
Gel Differin® intended for external use only. If swallowed even small amounts of the drug, should be rinsed stomach, symptomatic therapy if necessary.
pharmachologic effect
Pharmacological group:
Acne treatment for rashes.
Pharmacodynamics:
Adapalene – retinoid metabolite, which acts on the pathological mechanism of Acne vulgaris, is a potent modulator of cell differentiation and keratinization and komedonoliticheskoy and possesses antiinflammatory activity. The mechanism of action of adapalene is based on the interaction with specific gamma receptors of the epidermal skin cells. As a result of a reduction in adapalene “entanglement” epithelial cells in the mouth of the pilosebaceous follicle and reduce the formation of microcomedo. Adapalene has anti-inflammatory action in vivo and in vitro, acting on factors inflammation by inhibiting leukocyte migration in inflammation inhibits chemotactic and chemokinetic responses of polymorphonuclear leukocytes of human and inhibits metabolism of arachidonic acid to inflammatory mediators, AP-1 factors and the expression of Toll-like receptor 2 .
Pharmacokinetics:
Adapalene absorption through the skin is very low (about 4% of the applied dose). The excretion from the organism occurs mainly through the bile.
Pregnancy and breast-feeding
Pregnancy
Clinical experience with topical adapalene in pregnancy is limited, but the available data in patients receiving the drug in early pregnancy does not indicate its negative influence on the course of pregnancy or on the health of the fetus.
Due to the limited nature of available data, as well as due to the possibility of a slight penetration of adapalene through the skin, the drug Differin® should not be used during pregnancy.
In the case of pregnancy, treatment should be discontinued.
Breastfeeding
Studies of penetration of the drug into the breast milk of animals or humans after application to the skin have been conducted.
Since systemic exposure Differin® drug in breastfeeding women is low, it is not expected any impact on children who are breastfed. Differin® drug can be used during breastfeeding.
In order to avoid contact with the preparation of an infant when using the drug Differin® during breastfeeding should avoid drawing on the chest area.
Conditions of supply of pharmacies
Without a prescription.
side effects
Differin® drug may cause the following undesirable drug reactions:
Violations of the skin and subcutaneous tissue
Often (> 1/100 to
Infrequently (> 1/1000 to
Frequency unknown – fllergichesky dermatitis (allergic contact dermatitis), skin pain, skin swelling, irritation age, age of erythema, pruritus, age, eyelid swelling
If any of these instructions side effects are compounded or observed any other side effects not mentioned in the instructions, you should immediately inform your doctor.
special instructions
When development is suspected hypersensitivity reactions or severe skin irritation should stop using the product.
In some cases, depending on the degree of skin irritation, the number of applications can be reduced or treated suspended until disappearance of irritation. The resumption of treatment may, after consultation with the doctor.
Avoid gel contact with the eyes, mouth, nose corners and on mucous membranes.
In case of accidental contact of the preparation on the mucous membranes of the eyes, wash them with warm water.
The drug should not be applied on the damaged by trauma (cuts or abrasions) sunburn or eczematous skin.
For the treatment of severe nodular acne conglobata and apply systemic antibacterials + adapalene, benzoyl peroxide or combination of adapalene + benzoyl peroxide. In this case, adapalene can be used for the treatment of acne on the face, chest or back under the supervision of a physician.
But we should not use adapalene monotherapy in patients with severe acne on large areas of skin.
To avoid skin irritation when applied adapalene need to minimize exposure to sunlight and artificial UV radiation, including sunlight lamp. If you avoid exposure is not possible, we recommend the use of sunscreen and clothing to protect the drug-treated skin.
In applying the drug Differin® possible to use cosmetic products that do not have comedogenic or astringent properties.
Differin® gel contains methyl parahydroxybenzoate (E218), which may cause allergic reactions during or after treatment, and propylene glycol, which may be irritating to the skin.
Effects on ability to drive and use machines
Differin® gel has no influence on the ability to drive vehicles and operate machinery.
Storage conditions
At temperatures above 25 ° C. Do not freeze.
Keep out of the reach of children.
Dosing and Administration
For external use only.
The gel should be applied to a thin layer to the affected areas of skin acne once daily at bedtime to clean dry skin, avoiding a gel in the eye, lips, and mucous membranes of the nose corners.
Clinical improvement develops after 4-8 weeks of treatment, sustained improvement after a 3-month course of treatment.
Since the treatment of acne taken alternation therapy methods, after 3 months of therapy with recommended to consult with your doctor about further treatment.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist