Diclofenac suppositories 100mg 10 pieces


Diclofenac suppositories 100mg 10 pieces



Active substance:
1 suppository contains: Sodium diclofenac 100 mg.
Product form:
Rectal suppositories of 100 mg. 5 suppositories in blisters. 2 blisters together with instructions for use in paper cartons.
– the period after coronary artery bypass surgery; – III trimester of pregnancy, during breast-feeding; – children under the age of 6 years (for suppositories of 50 mg to 15; 100 mg Suppositories for children are not used); – hypersensitivity to active or auxiliary component; – anamnestic data fit bronchial, rhinitis, urticaria, after receiving aspirin or other NSAIDs (complete or incomplete syndrome intolerance of acetylsalicylic acid – rhinosinusitis, urticaria, polyps, nasal mucosa, asthma); – erosive and ulcerative changes in gastric mucosa and 12 duodenal ulcer, active gastrointestinal bleeding; – inflammatory bowel disease; – severe hepatic failure or active liver disease; – severe renal impairment (creatinine clearance less than 30 mL / min), progressive renal disease; – confirmed by hyperkalemia; – hemorrhoids.
Precautions I-II trimester of pregnancy, coronary heart disease, cerebrovascular disease, congestive heart failure, dyslipidaemia / hyperlipidemia, diabetes mellitus, peripheral arterial disease, smoking, creatinine clearance less than 60 mL / min.
A history of the development of ulcerative lesions gastrointestinal tract, the presence of infection Helicobacter pylori, long-term use of NSAIDs, frequent alcohol consumption, severe somatic diseases, concomitant therapy with the following drugs: – anticoagulants (eg, warfarin), – antiplatelet agents (eg, aspirin, clopidogrel), – oral corticosteroids (e.g., prednisone), – selective serotonin reuptake inhibitors (e.g., citalopram, fluoxetine, paroxetine, sertraline).
To reduce the risk of adverse effects on the gastrointestinal tract should use the lowest effective dose of the lowest possible short course.
Inflammatory diseases of the musculoskeletal system (rheumatoid arthritis, psoriatic, and juvenile chronic arthritis, ankylosing spondylitis, gouty arthritis).
Degenartivnye diseases of the musculoskeletal system (deforming osteoarthritis, low back pain).
Lumbago, sciatica, neuralgia, myalgia.
Diseases of extra-articular tissues (tendonitis, bursitis, rheumatic soft tissue damage).
Post-traumatic pain syndromes accompanied by inflammation, postoperative pain, migraine, renal or biliary colic; Primary algomenorrhea, adnexitis, proctitis.
Feverish syndrome.
NSAIDs are used for the symptomatic therapy to reduce pain and inflammation at the time of use, do not affect the progression of the disease.
Interaction with other drugs
Increasing the concentration of digoxin in plasma of methotrexate drugs lithium and cyclosporine.
Reduces the effect of diuretics, potassium-sparing diuretics in the background increases the risk of hyperkalemia; against the background of anticoagulants, thrombolytic agents (alteplase, streptokinase, urokinase) – The risk of bleeding (usually from the gastrointestinal tract).
Reduces the effect of antihypertensive and hypnotic drugs.
Increases the likelihood of side effects and other NSAIDs glucocorticosteroid means (bleeding in the gastrointestinal tract), the toxicity of methotrexate and cyclosporine nephrotoxicity.
Acetylsalicylic acid reduces the concentration of diclofenac in the blood.
Simultaneous use of paracetamol with increased risk of nephrotoxic effects of diclofenac.
Reduces the effect of hypoglycemic agents.
Cefamandole, cefoperazone, cefotetan, valproic acid and increase the incidence plicamycin hypoprothrombinemia.
Cyclosporine and preparations of gold increases the effect of diclofenac on the synthesis of prostaglandins in the kidneys, which increases the nephrotoxicity.
Simultaneous with the appointment ethanol, colchicine, corticotropin, serotonin reuptake inhibitors and drugs St. John’s wort increases the risk of bleeding in the gastrointestinal tract.
Diclofenac enhances the action of drugs that cause photosensitization.
Drugs that block tubular secretion, increase the concentration of diclofenac in plasma, thereby increasing its toxicity.
Simultaneous with the appointment of antibacterial drugs of the quinolone group increases the risk of seizures.
Symptoms: vomiting, dizziness, headache, shortness of breath, dizziness, children – myoclonic seizures, nausea, abdominal pain, bleeding, abnormal liver function and kidney.
Treatment: administration of activated charcoal, symptomatic therapy, forced diuresis.
Hemodialysis is ineffective.
pharmachologic effect
Pharmacological group:
Nonsteroidal anti-inflammatory drug (NSAID).
Pharmacological properties:
Diclofenac possesses anti-inflammatory, analgesic and antipyretic action. Non-selectively inhibiting cyclooxygenase 1 and 2, it gives the arachidonic acid metabolism, reduces the amount of prostaglandins in inflammation. In rheumatic diseases inflammatory and analgesic effect of diclofenac contributes to a significant reduction in the severity of pain, morning stiffness, swelling of the joints, which improves the functional state of the joint. When trauma, postoperative diclofenac reduces pain and inflammatory edema.
Absorption – rapid and complete. The maximum drug concentration achieved after 30 minutes. The plasma concentration is in linear dependence on the magnitude of the dose administered. Changes in the pharmacokinetics of diclofenac on the background of multiple doses is not marked, not accumulates.
Bioavailability – 50%. Relationship to plasma proteins – 95-98% (most associated with albumin). Penetrates into the synovial fluid. The maximum concentration in the synovial fluid is observed in 2-4 hours later than in plasma. The half-life of 3-6 hours synovial fluid (the concentration of active agent in the synovial fluid after 4-6 h after administration is higher than in the plasma, and remains higher for a further 12 hours). The relationship of drug concentration in synovial fluid from the clinical efficacy of the drug is not clear.
Metabolism occurs as a result of single or multiple hydroxylation and conjugation with glucuronic acid. The metabolism of the drug is involved enzyme system P450 CYP2C9. The pharmacological activity of the metabolites is lower than diclofenac.
Systemic clearance is 350 ml / min, the volume of – 550 ml / kg. 65% of the administered dose excreted by the kidneys as metabolites; less than 1% is excreted in unaltered form, the remainder of the dose excreted in bile as metabolites.
In patients with renal failure (less than 10 ml / min creatinine clearance) increases the excretion of metabolites in the bile, thus increasing their concentration in the blood is not observed.
In patients with chronic hepatitis or compensated cirrhosis pharmacokinetic parameters of diclofenac are not changed.
Pregnancy and breast-feeding
Diclofenac passes into breast milk.
Conditions of supply of pharmacies
On prescription.
side effects
Often – 1-10%; sometimes – 0.1-1%; rarely – 0.01-0.1%; very rarely – less than 0.01%, including some cases.
From the digestive system: often – nausea, vomiting, diarrhea, dyspepsia, flatulence, anorexia, increased aminotranferaz activity; rarely – gastritis, proctitis, gastrointestinal bleeding, gastrointestinal ulcers (with or without bleeding or perforation), hepatitis, jaundice, liver dysfunction; very rarely – stomatitis, glossitis, diafragmopodobnye bowel strictures (nonspecific hemorrhagic colitis, exacerbation of ulcerative colitis or Crohn’s disease), constipation, pancreatitis, fulminant hepatitis, exacerbation of hemorrhoids.
From the nervous system: often – headache, dizziness; rarely – drowsiness; very rarely – a violation of the sensitivity, including paresthesia, memory disturbances, tremors, convulsions, anxiety, cerebrovascular disorders, aseptic meningitis, confusion, depression, insomnia, night “nightmares”, irritability, personality disorders.
From the senses: common – vertigo; very rarely – blurred vision (blurred vision, diplopia), impaired hearing, tinnitus, taste disturbance.
From the urinary system: often – fluid retention; very rarely – acute renal failure, hematuria, proteinuria, interstitial nephritis, nephrotic syndrome, papillary necrosis, oliguria, azotemia.
From the side of hematopoiesis: rarely – thrombocytopenia, leukopenia, hemolytic and aplastic anemia, agranulocytosis, eosinophilia, thrombocytopenic purpura, worsening of infectious processes (development of necrotising fasciitis).
Allergic reactions: anaphylactic / Anafi-laktoidnye reaction including pronounced decrease in blood pressure and shock; very rarely – angioneurotic edema (including face).
With the cardiovascular system: very rarely – palpitations, chest pain, high blood pressure, vasculitis, heart failure, myocardial infarction.
The respiratory system: rarely – cough, bronchospasm, bronchial asthma (including shortness of breath); very rare – swelling of the larynx, pneumonitis.
For the skin: often – skin rash; rarely – urticaria; very rare – bullous rash, eczema, including multiforme and Stevens-Johnson syndrome, Lyell syndrome, toxic dermatitis, itching, loss of hair, photosensitivity, purpura, including allergic, melkotochechnye hemorrhage.
special instructions
The period of treatment should be systematic monitoring of peripheral blood picture, liver function, kidney, examination of feces for the presence of blood.
Patients treated with the drug, it is necessary to refrain from activities that require high concentration and rapid mental and motor reactions, the use of alcohol.
Storage conditions
In dry protected from light at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
The drug used rectally (administered into the rectum). To remove the suppository from the blister, you should break off a single cell with a suppository by a notch and by separating the edges of the tape, pull for them in different directions. Suppository enter into the rectum pointed end, possibly deep. For easier insertion of the suppository it is recommended to bend, squat or lie on your side, legs crossed.
Suppositories adult dose of 100 mg 1 time per day.
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg


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