Diclofenac Gel quinacrine appearance. 1% 40g tuba

$2.54

Diclofenac Gel quinacrine appearance. 1% 40g tuba

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Quantity:

Description

Composition
Active substance:
100 g of gel contains: Sodium diclofenac in terms of 100% substance – 1 g ;.
Excipients:
Ethanol (ethyl alcohol rectified) – propylene glycol 25 g – 5 g of Carbomer 940 (Carbopol 980) – 0.9 g of diethanolamine – 1 g of liquid paraffin (vaseline oil) – 2.5 g, kokoilkaprilkaprat – 2.5 g, macrogol tsetostearat ( 20 macrogol cetostearyl ether) – 2 g of lavender oil – 0.05 g of orange flower oil (neroli oil) – 0.05 g purified water – 100 g
Description:
Gel from white to white with yellowish or grayish tinge of color, and odor.
Product form:
Gel for external application of 1%. 40 or 50 g in a tube of aluminum.
Each tube together with instructions for use in a stack of cardboard.
Contraindications
Hypersensitivity to diclofenac or to other components of the formulation; to acetylsalicylic acid or other NSAIDs. Erosive and ulcerative lesions of the gastrointestinal tract (exacerbation). Pregnancy (III trimester), lactation, infancy (up to 6 years), impaired skin integrity.
Carefully. Hepatic porphyria (exacerbation), erosive and ulcerative lesions of the gastrointestinal tract, severe liver and kidney disease, chronic heart failure, advanced age, bronchial asthma, pregnancy (I and II trimester).
Dosage
1 %
Indications
Inflammatory diseases of the musculoskeletal system (rheumatoid arthritis, psoriatic, juvenile chronic arthritis, ankylosing spondylitis); rheumatism of soft tissues (tendonitis, bursitis, periarticular tissue damage); degenerative diseases of the musculoskeletal system (osteoarthritis deformans, low back pain); posttraumatic inflammation of tendons, ligaments, muscles and joints (due to sprains, bruises and under load); pain and swelling associated with diseases of the muscles and joints (lumbago, sciatica, neuralgia, myalgia).
Interaction with other drugs
The drug can increase the effects of drugs that cause photosensitization. Clinically significant interactions are not described with other drugs.
Overdose
Very low systemic absorption of the active components of the preparation for external application makes it virtually impossible to overdose.
pharmachologic effect
Pharmacological group:
Nonsteroidal anti-inflammatory drug (NSAID).
Pharmacodynamics:
Nonsteroidal anti-inflammatory drug (NSAID), has a pronounced analgesic and anti-inflammatory effect. Non-selectively inhibiting cyclooxygenase type 1 and 2, it gives the arachidonic acid metabolism and prostaglandin synthesis, which is the main element in the development of an inflammation.
In rheumatic diseases reduces swelling, flushing and pain at rest and in motion, morning stiffness and swelling of joints, improving their functional capacity. When post-operative and traumatic injuries quickly suppress pain and inflammation phenomena in the field of application of the drug, promotes the resorption of post-traumatic hematoma. Water-Ethanol base further has local anesthetic action.
Pharmacokinetics:
When applied topically diclofenac well penetrates the skin, mostly concentrating in inflammation and synovial fluid. The amount of diclofenac that is absorbed through the skin, proportional to the time of contact with the skin of the gel and the area of ​​its application depends on the total dose of the drug and the degree of skin hydration. When the preferred method of application of the drug is not absorbed more than 6% of diclofenac. Application of an occlusive dressing during 10 hours leads to 3-fold increase in the resorption of diclofenac. Binding to plasma proteins (mainly albumin) is 99%. It is metabolized in the liver, principally by hydroxylation to form multiple derivatives, two of which are pharmacologically active, but to a lesser extent than diclofenac. Excreted by the kidneys (approximately 65%) and in bile (approximately 35%) in the form of inactive compounds with glucuronic acid and sulfuric acid; less than 1% is excreted in unaltered form. Total systemic plasma clearance of diclofenac is, on average, 263 ml / min, the final withdrawal period – 1-2 hours.
Pregnancy and breast-feeding
The drug should not be used in the III trimester of pregnancy. Experience with the drug during lactation is not available. The use of I and II trimesters is possible only after consultation with your doctor.
Conditions of supply of pharmacies
Without recipe.
side effects
Local reactions: eczema, contact dermatitis (itching, redness, swelling the treated skin area, papules, vesicles, desquamation).
Systemic reactions: generalized skin rash, allergic reactions (including bronchospasm, angioedema), photosensitivity.
special instructions
The preparation should be applied only to undamaged skin, avoiding contact with open wounds, the eyes and mucous membranes. After application of the preparation should wash their hands if this area is not being treated. Avoid imposing occlusive dressings.
Before use in patients with gastric ulcer and duodenal ulcer, bronchial asthma, rhinitis, polyps, nasal mucosa, impaired liver function, kidney or hemopoietic system, and while the use of other nonsteroidal anti-inflammatory drugs should consult a physician.
When using the drug in conjunction with other dosage forms of diclofenac should be considered the maximum daily dose.
When applied to a large surface of skin for a long time increases the risk of systemic side effects typical of NSAIDs.
Effects on ability to drive and engage in other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Does not affect.
Storage conditions
At a temperature of 15 to 25 C. Keep out of reach of children.
Dosing and Administration
Outwardly. Adults and children over 12 years of drug applied to the skin 3-4 times a day and gently rubbed. The required amount of the drug depends on the size of the painful area. A single dose is 4.2 g (that is comparable in terms of size, respectively, with cherry or walnut).
Children from 6 to 12 years old, do not use more than 2 times per day, a single dose of the drug up to 2 years length of treatment depends on the indication and celebrated effect. After 2 weeks of use of the drug should consult a doctor.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

QUINACRINE INN

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