Diazolin pills 100mg 10 pieces Valenta Pharm

Description

Composition
Active substance:
1 tablet contains: mebhydrolin napadizilat (mebhydrolin) – 50 mg or 100 mg ;.
Excipients:
Microcrystalline Cellulose – 54.00 mg or 83.20 mg. lactose monohydrate – 30.80 mg or 48.00 mg, croscarmellose sodium – 1.40 mg or 2.40 mg colloidal silicon dioxide (Aerosil) – 1.00 mg or 1.60 mg Calcium stearate – 1.40 mg or 2.40 mg talc – 1.40 mg or 2.40 mg;
Coating: Opadry II 85F38209 – 6,00 mg or 7,00 mg: partially hydrolyzed polyvinyl alcohol – 40.00%, macrogol-3350 – 20.20% talc – 14.80% titanium dioxide 171 H – 24.89%, iron oxide yellow colorant E 172 – 0.11%.
Description:
Round biconvex tablets, film-coated off-white color with a yellowish tint. On the cross-section of the core is almost white.
Product form:
Tablets, film-coated, 50 mg and 100 mg.
10 tablets in blisters of PVC film and aluminum foil printed patent. 1 or 3 blisters together with instructions for use placed in a pile of cardboard.
Contraindications
Hypersensitivity to mebhydrolin and other ingredients, prostatic hyperplasia, angle-closure glaucoma, peptic ulcer and duodenal ulcer, inflammatory gastrointestinal disease, pyloric stenosis. epilepsy, heart rhythm disorders, pregnancy, lactation, children under 3 years of age, lactose intolerance, lactase deficiency, glucose-galactose malabsorption.
Hepatic and / or renal failure (may require dosage adjustment and intervals between doses).
Dosage
100 mg
Indications
Prevention and treatment of allergic rhinitis, pollinosis, urticaria, angioneurotic edema, allergic dermatosis accompanied by pruritus (eczema, neurodermatitis); allergic conjunctivitis, skin reaction after an insect bite.
Interaction with other drugs
Potentiates the effect of ethanol sedatives.
Overdose
Symptoms: confusion, drowsiness, incoordination. Subsequently, as the suction received drug inhibition CNS signs can be amplified up to the occurrence of coma. Overdose may also lead to a stimulating effect on the central nervous system (more common in children). Can also develop manifestations of anticholinergic action: dry mouth, dilated pupils, flushing to the upper half of the body, disorders of the gastrointestinal tract (nausea, epigastric pain, vomiting).
Treatment: removal of the drug, gastric lavage, reception activated charcoal, if necessary – symptomatic therapy.
pharmachologic effect
Pharmacological group:
Antiallergic agent – H1-histamine receptor blocker.
Pharmacodynamics:
Blocker H1-histamine receptors. It has anti-allergic effect, reduces the swelling of mucous membranes. Reduces the effect of histamine on bronchial smooth muscle, uterine and bowel, reduces the severity of reducing blood pressure and increasing vascular permeability. Slightly penetrate into the central nervous system (CNS), in contrast to the first generation antihistamines, does not exert sedative and hypnotic action. It has a mild M-cholinergic and anesthetic properties.
Therapeutic effect develops after 15-30 min after administration, the maximum effect is observed after 1-2 h. The duration of effect can be up to 2 days.
Pharmacokinetics:
Rapidly absorbed from the gastrointestinal tract (GIT), penetrates into all tissues of the body. The bioavailability of 40-60%. Plasma half-life is about 4 hours. Practically it does not penetrate the blood-brain barrier. It is metabolized in the liver by methylation induces hepatic microsomal enzymes excreted by the kidneys.
Pregnancy and breast-feeding
The drug is contraindicated during pregnancy.
If necessary, use during lactation at the time of treatment should stop breastfeeding.
Conditions of supply of pharmacies
Without recipe.
side effects
On the part of the digestive tract: irritant effect on the gastrointestinal mucosa, manifested by dyspepsia (heartburn, nausea, epigastric pain).
From the nervous system: dizziness, paraesthesia, tremor, fatigue, drowsiness, anxiety (but at night), slowing of psychomotor reactions.
Other: dry mouth, urinary retention, allergic reactions, granulocytopenia and agranulocytosis.
The children – paradoxical reactions: anxiety, irritability, tremors, sleep disorders.
special instructions
Effects on ability to drive vehicles and management mechanisms.
During the period of treatment should refrain from driving and from classes other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Storage conditions
The protected reflection at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
The inside is not liquid, during or immediately after a meal.
Adults and children from 12 years appoint 100 mg 1-3 times a day. The maximum dose for adults: single – 300 mg. daily – 600 mg.
Duration of treatment is determined by the nature of the disease and the therapeutic effect achieved.
For children aged 3 to 5 years, 50 mg 1-2 times a day, from 5 to 10 years, 50 mg 2-3 times a day, from 10 to 12 years, 50 mg 3-4 times a day.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist