Diafleks Rompharm caps. 50mg 30 pc

Description

Composition
Active substance:
1 capsule contains: diacerein – 50 mg ;.
Excipients:
Magnesium stearate – 12, 5 mg, lactose monohydrate (Kapsulak 60) – up to 250 mg; Capsule composition: Titanium dioxide – 0.75 mg iron oxide yellow dye – 2.2125 mg, gelatin – up to 75.0 mg.
Description:
Hard gelatin capsules number 1 yellow with slight brownish tinge. Contents of capsules – powder yellow.
Product form:
Capsules of 50 mg. 10 capsules in blisters made of PVC / aluminum foil. 3 blisters together with instructions for use placed in a cardboard box.
Contraindications
Hypersensitivity to diacerein, other components (including to the anthraquinone drugs (laxatives)), age 18 years. Lactose intolerance, lactase deficiency, malabsorption glyukozogalaktoznaya
Carefully
Severe hepatic or renal insufficiency, intestinal obstruction, inflammatory bowel disease.
Dosage
50 mg
Indications
Primary and secondary osteoarthritis.
Interaction with other drugs
Diacerein Rompharm advised not to take in conjunction with drugs that increase the volume of the intestinal contents (e.g., a large number of fiber). Antacids reduce the absorption of the drug. When concomitantly with antibiotics or chemotherapeutic drugs affecting the intestinal microflora may increase incidence of adverse effects from the bowel. Medicines (PM), comprising aluminum hydroxide and / or magnesium hydroxide, reduce bioavailability of diacerein. The simultaneous use is not recommended with laxatives.
Overdose
Symptoms: diarrhea, weakness.
Treatment: symptomatic. In severe diarrhea should be monitored plasma electrolyte composition.
pharmachologic effect
Pharmacological group:
Nonsteroidal anti-inflammatory drug (NSAID).
Pharmacological properties:
Diacerein – derivative antrahinolina, diacetylated derivative rei- on. To the active metabolite metabolizing – rhein inhibits the activity of interleukin-1, which plays an important role in the development of inflammation and cartilage degradation in osteoarthritis. Inhibits the action of other cytokines (including IL-6, necrosis factor-alpha tumor). The action develops within 2-4 weeks. Diacerein has analgesic anti-inflammatory activity when administered orally.
Pharmacokinetics:
Rapidly absorbed from the gastrointestinal tract (GIT), the bioavailability is increased by 25% at the same time taking with food. The time to reach maximum concentration (TCmax) – 144 min. In single dose Cmax of 50 mg – 3.15 mg / L, at multiple dose due to cumulation Cmax drug increases. Fully deacetylated to rhein. Communication with rhein proteins (albumin) to 100%. Reine crosses the placental and blood-brain barriers. The half-life (T1 / 2) – 255 min. Excreted by the kidneys in unchanged form (20%) as a glucuronide (60%), as sulfate – 20%.
Pregnancy and breast-feeding
The drug is contraindicated during pregnancy and lactation. While taking the drug should be abolished breastfeeding.
Conditions of supply of pharmacies
On prescription.
side effects
From the digestive system: diarrhea, nausea, vomiting, abdominal pain, hepatitis. Allergic reactions: rash, fever, bronchoconstriction, angioneurotic edema, anaphylactic shock. Miscellaneous: malaise, intense staining urine (depending on pH) from yellow to brown (no clinical significance).
special instructions
The duration of treatment may be lengthy. Prior to the onset of therapeutic effect, diacerein may be administered simultaneously with analgesic drugs (including NSAIDs). A periodic monitoring of blood parameters, liver function tests (determination of the level of liver transaminases), urine (creatinine levels and creatinine clearance). When renal function deterioration must be reduced dose. In patients with chronic renal failure, with CC less than 30 ml / min diacerein dose should be reduced to 50 mg / day and is then titrated according tolerability and clinical efficacy. Staining urine can complicate interpretation of urine analysis results (e.g., glucose).
The effect on the ability to operate vehicles, machinery
No information.
Storage conditions
In the dark place at a temperature not higher than 25 C.
In the reach of children.
Dosing and Administration
Inside, after eating, you must be swallowed whole, without chewing, drinking water, 50 mg 2 times a day (morning and evening). Continuous or prolonged courses (at least 4 months). Diacerein Rompharm during the first two weeks can cause accelerated transit in the intestine, therefore it is recommended to begin treatment with one capsule per day in the evening with food for 4 weeks. Thereafter, the dosage is increased up to 100 mg / day.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist