Devirs cream naruzhn.prim-I 7.5% 15g tube vertex


Devirs cream naruzhn.prim-I 7.5% 15g tube vertex


SKU: 01112390735 Categories: , , Tags: ,


Active substance:
100 g of cream contains: ribavirin 7.5 g
Glyceryl monostearate (glycerol monostearate 40-45) – 2.0 g, macrogol cetostearyl alcohol ester 6 (6 macrogol cetostearyl ether) – 1.5 g, 25 macrogol cetostearyl alcohol ether (25 macrogol cetostearyl ether) – 1.5 g, cetostearyl alcohol – 5.0 g, liquid paraffin (vaseline oil) – 5.0 g methyl parahydroxybenzoate (methyl hydroxybenzoate, methyl paraben, nipagin) – 0.1 g propyl parahydroxybenzoate (propyl hydroxybenzoate, propyl, Nipasol) – 0.02 g purified water – to 100.0 g
Uniform cream white or nearly white.
Product form:
Cream for external use of 7.5%.
5 g, 15 g or 30 g aluminum tubes. Each tube together with instructions for use placed in a pile of cardboard.
Hypersensitivity to ribavirin or other components of the drug, pregnancy, lactation, childhood and adolescence (18 years).
Renal insufficiency.
Be wary of the women and men of reproductive age.
The cream can be applied as a monotherapy, or in combination with other dosage forms of ribavirin intended for parenteral and oral use of the following diseases: 1. Infections of the skin and mucous membranes, caused by Herpes simplex viruses types 1 and 2, various sites, including including the genital area. 2. Herpes zoster (in the complex therapy).
Interaction with other drugs
Not found.
pharmachologic effect
Pharmacological group:
An antiviral agent.
Pharmacological properties:
Ribavirintrifosfat (RTF) is a powerful inhibitor of inosine monophosphate dehydrogenase (IMP dehydrogenase), viral RNA polymerase and viral mRNA guanylyltransferase. Inhibition latter ceases mRNA capping, which results in a significant depletion of intracellular stores of guanosine triphosphate and inhibition of viral RNA synthesis and protein. Ribavirin is also built into the viral genome, causing lethal mutations, followed by reduction of pathogenicity of the virus. Ribavirin inhibits the replication of new virions that provides reduction in viral load, selectively inhibits the synthesis of viral RNA without inhibiting RNA synthesis in the normally functioning cells. The most sensitive to ribavirin DNA viruses – herpes simplex virus, adenovirus, CMV, viruses group pox, Marek’s disease; RNA viruses – influenza viruses A, B, paramyxoviruses (parainfluenza, mumps, Newcastle disease), reoviruses, arenaviruses (Lassa virus, Bolivian hemorrhagic fever), bunyaviruses (virus Rift Valley fever virus Crimean-Congo hemorrhagic fever), hantaviruses virus (hemorrhagic fever with renal syndrome or lung) RNA oncogenic viruses.
Insensitive to ribavirin DNA viruses: Varicella zoster, the virus pseudorabies natural vaccinia; RNA viruses: enteroviruses, rhinoviruses, encephalitis virus Semliki Forest.
When applied topically to the skin, and systemic absorption is minimal and virtually insignificant.
Pregnancy and breast-feeding
Applying the cream during pregnancy and lactation is contraindicated.
Conditions of supply of pharmacies
Available on medical prescription.
side effects
Allergic reactions (rash, hives, rash).
Other: hair loss, changes in the content of thyroid stimulating hormone (TSH), the symptoms of autoimmune diseases (rarely).
The observed effects are generally reversible, do not affect the effectiveness of treatment and stop after the end of treatment.
special instructions
Do not use for the treatment of ophthalmic, do not apply in the eye area.
The drug should be used with extreme caution in patients with renal insufficiency.
Men and women of childbearing age during treatment and for 7 months after treatment should use effective contraception.
Storage conditions
In a dry, the reach of children at a temperature not higher than 25 C.
Dosing and Administration
Topically applied to the affected areas of skin and mucous membranes (previously washed and dried) uniform thin layer, gently rubbing.
Applied 5 times a day until complete disappearance of symptoms.
If there is no improvement within 8 days of the drug stop taking and consult a doctor.
For the best possible treatment should be started as early as possible at the first appearance of symptoms.
In case Devirs cream administered in combination with one of the ribavirin dosage forms for oral or intravenous administration, the dose should be reduced cream.
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg


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