Detrimaks vitamin d3 Table n / 230mg 1000me about 60 pc

Description

Composition
Active substance:
Vitamin D3 (cholecalciferol).
The content of active substances in 1 tablet: Vitamin D3-25 g (1000 IU).
Excipients:
Calcium ortho-phosphate 2-substituted (carrier), microcrystalline cellulose E460 (Flowing agent).
tablet shell (E464 hydroxypropylmethylcellulose (vehicle), titanium dioxide E171 (dye), polydextrose E1200 (stabilizer), talc E553 (Flowing agent), maltodextrin, medium chain triglycerides), magnesium salt of stearic acid (stabilizer).
Description:
DETRIMAKS® Vitamin D3 provides vitamin D3 (cholecalciferol) – the vital fat-soluble vitamin necessary for the operation of almost all organs and systems of the human body.
Vitamin D plays a key role in:
The skeletal system.
Participates in the regulation of calcium and phosphorus metabolism: helps calcium absorbed in the intestines, supports the necessary levels of calcium and phosphorus in the blood, activates bone metabolism. Promotes bone strength and teeth, reduce the risk of rickets, osteomalacia. (1.2)
Muscular system.
It helps to maintain muscle strength and neuromuscular conduction (3), thereby reducing the risk of falls and fractures.
IMMUNE SYSTEM.
It promotes healthy immune function activation, positively affecting both innate and acquired immunity (3). It triggers the synthesis of the body’s own antimicrobial peptides: katalitsidina and defensin. Thereby reducing the risk of colds (4). It has a regulating effect on the growth, development and regeneration of cells (5,3). Lack of vitamin D in the body leads to a weakening of the immune defense.
Regulation of energy potential of the cells.
Helps relieve fatigue and improve body tone, regulating its own energy potential of the cells. As a result, the influence of vitamin D in the mitochondria of cells increased production of ATP (adenosine triphosphate), which own universal energy source for all biochemical processes in the body (7).
NERVOUS SYSTEM.
Positive effect on the nervous system, including the psycho-emotional sphere and cognitive functions: mood, memory, attention, efficiency, overall body as involved in the production of neurotransmitters and biologically active substances by means of which the transmission of nerve impulses between nerve cells (3) . It is required for the conversion of tryptophan (amino acids entering into the body with food) to serotonin – neurotransmitter having great significance for normal cognitive and psycho-emotional state. It helps to improve mood (9). Vitamin D is capable of exerting positive action on pain sensitivity due to a positive influence on the synthesis of neurotransmitters: serotonin, dopamine (10).
Bronchopulmonary system.
It helps prevent airway smooth muscle changes, regulates contraction of airway muscles and inflammatory response that contributes to normal lung function (11).
Endocrine system.
Vitamin D affects the metabolism of glucose and insulin, and vitamin D deficiency is a risk factor for the development of insulin resistance, impaired glucose tolerance. Vitamin D can stimulate secretion from the beta cells of pancreatic insulin, and indirectly activates the calcium-dependent endopeptidase beta cells that converts proinsulin to insulin is active. Vitamin D can affect tissue sensitivity to insulin, either directly, by stimulating expression of insulin receptors in cells (14). Vitamin D positive effect on lipid metabolism, contributing to a reduction of low density (15) in the blood levels of total cholesterol, triglycerides, and lipids.
Reproductive function.
It stimulates the synthesis of male and female sex hormones: estrogen, progesterone, testosterone. It has a positive effect on the reproductive function in both women and men (12,13). Couples who are planning a pregnancy or have difficulty in conceiving a child. In women with adequate levels of vitamin D3 fertilization occurs more often. Lack of vitamin D3 deficiency can improve the results of IVF. Most likely, this effect is due to the effect of vitamin D3 on the endometrium. In addition, D3 plays an important role in the correction of obesity and the metabolic syndrome. Studies have revealed that the intake of vitamin D3 mother accompanied by a lower risk of obstructive lung disease in children.
Cardiovascular system.
Vitamin D plays a protective role in maintaining the function of the cardiovascular system. Positively affects the inner layer and the muscular wall of the vessels, as well as processes of blood coagulation (16,17).
Vitamin D helps: 1. Maintaining a healthy immune function. 2. Strengthening of the musculoskeletal system. 3. Improving the energy potential of the organism. 4. the maintenance of normal functioning of the nervous system. 5. maintain normal reproductive function in both women and men.
Important additional information.
Epidemiological studies (19), held in Russia, found that reducing the concentration of vitamin D in the blood is observed in 50-92% of the adult population of working age and children, regardless of the season.
Vitamin D deficiency causes a large proportion of the population are Russian as its insufficient dietary intake and the low level of its synthesis in the skin due to the geographical location of the RF (low insolation) (19).
Impairments associated with a deficiency of vitamin D:
The main manifestation of vitamin D deficiency in children is rickets in adults – osteomalacia.
Older people have vitamin D deficiency in the first place is associated with muscle weakness, poor physical function and imbalance, increased bone fragility.
Commission on dietetic products, nutrition and allergies of the European food agency Committee on Food Safety established between the intake of vitamin D from food and its contribution to the proper functioning of the immune system.
Literature: 1. European Food Safety Authority (EFSA), Scientific Opinion on the substantiation of a health claim related to vitamin D and contribution to normal bone and tooth development pursuant to Article 14 of Regulation (EC) No 1924/20061 EFSA Journal 2014; 12 (2): 3579 2. European Food Safety Authority Scientific Opinion on the substantiation of a health claim related to vitamin D and risk of falling pursuant to Article 14 of Regulation (EC) No 1924/20061 / EFSA Journal 2011; 9 (9): 2382 3. European Food Safety Authority. Scientific Opinion on the substantiation of health claims related to vitamin D and normal function of the immune system and inflammatory response (ID 154,159), maintenance of normal muscle function (ID 155) and maintenance of normal cardiovascular function (ID 159) pursuant to Article 13 (1) of Regulation (EC) No 1924/20061 / EFSA Journal 2010; 8 (2): 1468 [17 pp. ]. 4. Adrian R Martineau David A Jolliffe, Richard L Hooper, et al. Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of individual participant data ‘. BMJ 2017: 356: 16583.) 5. Martin Hewison Vitamin D and immune function: an overview Proceedings of the Nutrition Society (2012), 71,50-61 6. Snopov CA Mechanisms of action of vitamin D on the immune system. Medical Immunology 2014, T. 16, № 6, pp. 499-530 7. Roger Bouillon and Annemieke Verstuyf. Vitamin D, Mitochondria, and Muscle / J. Clin Endocrinol Metab, March 2013,98 (3): 961-963 8. Mathias Schlagl Michael F Holic Vitamin D and neurocognitive function Clinical Interventions in Aging 2014: 9, 559-568 9. Rhonda P. Patrickl and Bruce N. Amesl Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism / The FASEB Joumal. 2017, Vol. 28, No. 6, pp: 2398-2413. 10.
Edward A. Shipton and Elspeth E. Shipton Vitamin D and Pain: Vitamin D and Its Role in the Aetiology and Maintenance of Chronic Pain States and Associated Comorbidities. / Pain Research and Treatment. Volume 2015, Article ID 904967,12 pages 11.
Martineau AR, Cates CJ. Urashima M, Jensen M. Vitamin D for the management of asthma. Cochrane Database of Systematic Reviews 2016, Issue 9. Art No. : CD011511 12.
SY Kalinchvnko, MI Zhilenko ,. YES. Gusakova et al. Vitamin D and women’s reproductive health problems of reproduction, 4.2016 S.28-36. thirteen.
Tyuzikov IA, Kalinchenko SY .. Vorslov LO, Tishova SA. Vitamin D, men’s health and male reproduction / Andrology and Genital Surgery. 2013.№4. S. 36-44. 14.
Mathieu C. Gysemans S. Vitamin D and diabetes. Av Diabetol. 2006; 22 {3): 187-193. fifteen.
Tina Jafari, Aziz A. Fallah, Afshin Barani. Effects of vitamin D on serum lipid profile in patients with type 2 diabetes: A meta-analysis of randomized controlled trials. / Clinical Nutrition. 35 (2016) 1259-1268. 16.
O.M. Dralkina, P.H. Shepel. Pgeyotropnye effects of vitamin D3. Rational pharmacotherapy therapy in Cardiology 2016; 12 (2): 227-233 17.
Dudinskaya E. Tkacheva ON ND The role of vitamin D in the development of hypertension and the prevention of Cardiovascular Therapeutics 2012; 11 (3) 6 SYU77-81. 18.
Kodentsova VM, Mendel OI HotimchenkoSA., Baturin AK, NikityukD.
B. Tutelian VA physiological needs and effective doses of vitamin share correction of its deficit. State of the art. Nutrition. 2017 v.86. №2, S.47-62.
Product form:
Coated tablets with dividing Valium weighing 230 mg of 12 pieces in the blister, 2 or 4 in the blister pack carton; 15 pieces in a blister, 2,4,6 or 8 in the blister pack carton; for 30,60,90 or 120 pieces in a bottle, 1 bottle in a cardboard pack.
Contraindications
Individual intolerance to the components. Before applying are encouraged to consult with a physician. It is not a drug.
Indications
It is recommended as a dietary food supplement – additional source of vitamin D.
Fat-soluble vitamin D is well absorbed in the gastrointestinal tract due to the formation in the environment of the small intestine micellar compounds.
Conditions of supply of pharmacies
Without recipe.
Storage conditions
Keep out of reach of children at a temperature not higher than 25 ° C.
Dosing and Administration
Adults take 1/2 tablet a day during meal time. The duration of intake -1 month.
DETRIMAKS Vitamin D3 has no contraindications during pregnancy, but should be taken with caution. Before applying are encouraged to consult with a physician.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist