Detraleks tab n / 500mg film about 30 pc

Description

Composition
Active substance:
500 mg of micronized purified flavonoid fraction consisting of 450 mg of diosmin (90%) and flavonoids, hesperidin, based on 50 mg (10%).
Excipients:
gelatin 31.00 mg Magnesium stearate 4.00 mg Microcrystalline cellulose 62.00 mg sodium carboxymethylstarch 27.00 mg talc 6.00 mg 20.00 mg purified water.
Sheath Film: Macrogol 6000 0.710 mg Sodium lauryl sulfate 0,033 mg, premix for film coating an orange-pink color consisting of: glycerol 0.415 mg magnesium stearate 0.415 mg hypromellose 6.886 mg of dye iron oxide yellow 0.161 mg of dye oxide red iron 0.054 mg titanium dioxide 1.326 mg.
Description:
Oval tablets, film-coated, orange-pink color.
Kind of pills on a break from a pale yellow to yellow inhomogeneous structure.
Product form:
Tablets, film-coated, 500 mg
15 tablets in a blister (PVC / Al). 2 blisters with instruction for use in a cardboard box, a first opening control (if necessary).
Contraindications
Hypersensitivity to the active ingredients or excipients included in the preparation.
We do not recommend the drug to nursing women.
Dosage
500 mg
Indications
Detraleks® indicated for the treatment of chronic venous disease symptoms (elimination and the relief of symptoms).
Therapy symptoms venous-lymphatic insufficiency:
– pain;
– spasms of the lower limbs;
– a feeling of heaviness and fullness in the legs;
– “tired” legs.
Therapy manifestations of venous-lymphatic insufficiency:
– swelling of the lower extremities;
– trophic changes of the skin and subcutaneous tissue;
– venous trophic ulcers.
Symptomatic treatment of acute and chronic hemorrhoids.
Interaction with other drugs
Clinical studies of drug interactions Detraleks® preparation with other drugs was conducted. So far, not been reported with any cases of drug interactions.
Overdose
Overdose is not described.
If overdose seek immediate medical attention.
pharmachologic effect
Pharmacological group:
Venotoniziruyuschee and venoprotektornoe means.
Pharmacodynamics:
Detraleks® has angioproteguoe and venotonic properties.
The drug reduces the extensibility of the veins and venous stasis, reduces the permeability of capillaries and improves their resistance. Results of clinical studies confirm the pharmacological activity of the drug against venous hemodynamic indices.
A statistically significant dose-dependent effect of the drug was demonstrated Detraleks® following venous plethysmographic parameters: venous capacity, venous distensibility, venous emptying time.
The optimum ratio of “dose-effect” is observed when 2 tablets.
Detraleks® increases venous tone: using venous occlusion plethysmography been shown to decrease venous emptying time. Patients with signs of pronounced microcirculatory disorders, after therapy with Detraleks® observed (statistically significant compared to placebo), increased capillary resistance, estimated by angiostereometrii.
Detraleks® proved the therapeutic efficacy of the drug in the treatment of chronic diseases of the lower limbs, as well as in the treatment of hemorrhoids.
Pharmacokinetics:
Main drug selection occurs in the faeces. The urine output on average about 14% of the received amount of the drug.
half-life is 11 hours.
The drug undergoes active metabolism, which is confirmed by the presence of phenolic acids in the urine.
Pregnancy and breast-feeding
Pregnancy
Animal experiments did not reveal any teratogenic effects.
Until now there has been no reports of adverse effects when using the drug in pregnant women.
Lactation
Due to lack of data on the excretion of the drug in breast milk, breast-feeding women are not recommended to take the drug.
Effects on reproduction
Reproductive toxicity studies have not shown effects on reproductive function in rats of both sexes.
Conditions of supply of pharmacies
Available without prescription.
side effects
Side effects Detraleks® drug, observed during clinical studies were mild in severity. Advantageously marked disorders of the gastrointestinal (diarrhea, dyspepsia, nausea, vomiting).
At the time of taking the drug Detraleks® reported the following side effects in the form of the following gradation: very common (> 1/10); common (> 1/100,
special instructions
– Before you start taking the drug Detraleks®, it is recommended to consult a doctor.
– In acute hemorrhoids Detraleks® use of the drug does not replace specific treatment other anal disorders. The duration of treatment should not exceed the time specified in the “Method of administration and dose.” In that case, if the symptoms do not disappear after the recommended course of treatment, should be examined by a proctologist, who will pick up further therapy.
– In the presence of venous circulation disorders maximum effect of treatment provided by a combination therapy with a healthy (balanced) way of life: it is desirable to avoid a long stay in the sun longer stay on his feet, and recommended reduction of overweight. Hiking and
in some cases, wearing special stockings, it helps to improve blood circulation.
Consult a doctor immediately if, in the course of treatment, your condition worse or no improvement.
Effects on ability to drive and perform the work requires a high rate of mental and physical reactions
Clinical studies on the effect of the drug Detraleks® on ability to drive and perform work requiring a high rate of mental and physical reactions, have been conducted. However, on the basis of the available safety data, we can conclude that Detraleks® no effect (no significant effect) on these processes.
Storage conditions
Store at a temperature not higher than 30 ° C.
Keep out of reach of children
Dosing and Administration
Inside.
The recommended dose for venous-lymphatic insufficiency – 2 tablets per day (in one or two steps): in the morning, afternoon and / or evening mealtime. The tablets should be swallowed whole with water.
The duration of treatment may last several months (up to 12 months). In the case of recurrence of symptoms, on doctor’s advice, treatment can be repeated.
The recommended dose for acute hemorrhoid – 6 tablets per day: 3 tablets morning and evening for 3 tablets for 4 days, then 4 tablets per day: 2 tablets in the morning and 2 tablets in the evening over the next 3 days.
The recommended dose for chronic hemorrhoids – 2 tablets per day with meals.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist