Derinat solution for injection 1.5% 5ml ampoules 5 pcs

Description

Composition
Active substance:
100 ml of the preparation contains: sodium deoxyribonucleate 1.5 g
Excipients:
Sodium chloride 0.9 g Water for injection – 100 ml.
Description:
Transparent colorless liquid.
Product form:
A solution for intramuscular injection of 15 mg / ml. 5 mL glass vials from imported with injectable infusion stoppers-pallets in a blister cardboard pack № 2 or 5 ml glass vials with injectable imported infusion stoppers in pallets blister pack in a cardboard № 10.
Contraindications
Idiosyncrasy.
Dosage
1.5%
Indications
Radiation injury; violation of hematopoiesis; mielodeprescia and resistance to cytostatics in cancer patients that developed against the background of cytostatic and / or radiation therapy (stabilization hemopoiesis reduction cardio- and myelotoxicity of chemotherapy); stomatitis induced by cytostatic therapy; peptic ulcer and 12 tiperstnoj ulcers, erosive gastroduodenitis; coronary artery disease; obliterative lower limb vascular disease, chronic ischemic disease of lower limbs II – III stage; trophic ulcers, nonhealing wounds; odontogenic sepsis, purulent-septic complications; rheumatoid arthritis; burn disease; preoperative and postoperative periods (in surgery); Dysmenorrhea, salpinogooforit, endometriosis, uterine fibroids; chlamydia, ureaplasmosis, mycoplasmosis; prostatitis, benign prostatic hyperplasia; chronic obstructive pulmonary disease; pulmonary tuberculosis, inflammatory airways disease.
Interaction with other drugs
Application Derinat in complex therapy to improve the efficiency and reduce the duration of treatment, with a considerable reduction of doses of antibiotics and antiviral agents with increasing periods of remission.
Derinat increases the effectiveness of anticancer anthracyclines antibiotics, cytostatics.
The drug potentiates the therapeutic effect of basic therapy in gastric ulcer and 12 duodenal ulcer. Derinat reduce iatrogenic basic drugs in the treatment of rheumatoid arthritis with achieving 50% and 70% improvement on a number of complex indices of disease activity.
In surgical sepsis Derinat introduction of the combined therapy causes a decrease in the level of toxicity, immune activation, normalization of hemopoiesis, improves the bodies responsible for the processes of the internal environment of an organism detoxification (lymph nodes, spleen, etc.).
Overdose
Negative effects of overdose have been identified.
pharmachologic effect
Pharmacological group:
Immunomodulatory agent, a stimulant of hematopoiesis, regenerant, reparant.
Pharmacodynamics:
The drug activates the processes of cellular and humoral immunity. Immunomodulatory effect is caused by the stimulation of B-lymphocytes, activation of T-helper cells. Derinat activates nonspecific resistance of the organism, optimizing the inflammatory reaction and immune response to bacterial, viral and fungal antigens. Stimulates reparative and regenerative processes. Increases the body’s resistance to infections, regulates hematopoiesis (helps to normalize the number of leukocytes, lymphocytes, granulocytes, phagocytes, platelets). Having expressed lymphotropic, Derinat stimulates drainage and detoxification function of the lymphatic system. Derinat significantly reduces the sensitivity of cells to the damaging effects of chemotherapeutic drugs and radiotherapy. The drug has no embryotoxic, teratogenic or carcinogenic effects.
Pharmacokinetics:
Absorption and distribution
The drug is rapidly absorbed and distributed in organs and tissues via endolymphatic transportation way. It has high affinity for organs hematopoietic system, is actively involved in cellular metabolism, embedding into cell structure. In the intensive phase of receipt of the drug in blood is redistributed between the plasma and formed elements of blood, in parallel with the metabolism and excretion. After single injection for all pharmacokinetic curves describing the change in concentration of the drug in the studied organs and tissues, characterized by fast phase increase and rapid reduction phase concentration in the time interval 5 – 24 hours. The half-life (T 1/2) for intramuscular injection is 72.3 hours. Derinat rapidly distributed throughout the body, in a course of daily cumulated in organs and tissues: the maximum – in the bone marrow, lymph nodes, spleen, thymus; to a lesser extent – in the liver, brain, stomach, small and large intestines. Maximum concentration in the bone marrow is determined by 5 hours after drug administration. The drug overcomes the blood-brain barrier. The maximum drug concentration in the brain is achieved after 30 minutes.
Metabolism and excretion.
Derinat metabolized in the body. Excreted from the body (as metabolites) partially in the feces, and to a greater extent with the urine by biexponential dependence.
Pregnancy and breast-feeding
Should consult a doctor. The appointment of the drug during pregnancy should assess the expected benefit to the mother and the potential risk to the fetus. In the lactation period to apply strictly on prescription.
Conditions of supply of pharmacies
By prescription.
side effects
In patients with diabetes is marked hypoglycemic action that should be taken into account by controlling the level of blood sugar.
special instructions
The drug may be administered subcutaneously.
Storage conditions
Store in a dark place inaccessible to children at + 4 ° C to + 20 ° C.
Dosing and Administration
Adults: intramuscularly for 1-2 minutes with 5 ml of 1.5% (75 mg) solution, with an interval of 24-72 hours.
In ischemic heart disease – 10 injections with an interval of 48-72 hours.
In gastric ulcer and 12 duodenal ulcer – 5 injections every 48 hours.
In cancer – 3-10 injections at intervals of 24-72 hours.
In gynecology (endometriosis, chlamydia, ureaplasmosis, mycoplasmosis, salpinogooforit, fibroids, endometriosis) – 10 injections with intervals of 24-48 hours.
In Andrology (prostatitis, benign prostatic hyperplasia) – 10 injections with intervals of 24-48 hours.
Pulmonary tuberculosis – 10-15 injections with intervals of 24-48 hours.
In acute inflammatory diseases – 3-5 injections at intervals of 24-72 hours.
In chronic inflammatory diseases – 5 injections with an interval of 24 hours, then – 5 injections, at intervals of 72 hours.
When using a 1.5% solution in 2 ml intramuscular injections done daily, making recalculated, until the course dose 375-750 mg.
Children drug administered intramuscularly in the same way as adults. Children under 2 years of drug administered in a single dose of 7.5 mg (0.5 ml). Children aged 2 to 10 years of single dose is determined by the rate of 0.5 ml per year of life.
From the age of 10 single dose – 5 ml of a 1.5% solution, course dose – up to 5 injections (15 mg / ml) of the drug.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist