De-nol tab n / 120mg film about 32 pc

Description

Composition
Active substance:
1 tablet contains: bismuth tripotassium dicitratobismuthate -304.6 mg, in terms of bismuth oxide Bi2O3 -120 mg.
Excipients:
Corn starch, povidone KZ0, poliakrillat potassium, macrogol 6000, magnesium stearate. sheath: Opadry OY-S-7366, consisting of: hypromellose and Macrogol 6000.
Description:
Round biconvex tablets, coated creamy-white color, labeled «gbr 152″, embossed on one side and the graphic pattern in the form of a square with broken sides and rounded corners embossed on the other.
Product form:
To 8 tablets in a blister made of aluminum foil at 4.7 or 14 blisters together with instructions for use in a cardboard package.
Contraindications
Pronounced impairment of renal function, pregnancy, lactation, hypersensitivity to the drug.
Dosage
120 mg
Indications
Gastric ulcer and duodenal ulcer in the acute phase, including those associated with Helicobacter pylori.
Chronic gastritis and gastroduodenitis in the acute phase, including those associated with Helicobacter pylori.
Syndrome irritable bowel, flowing mostly with symptoms of diarrhea.
Functional dyspepsia is not related to organic disease of the gastrointestinal tract.
Interaction with other drugs
Within half an hour before and after taking De Nol is not suitable for use within other drugs, as well as receiving food and liquids, in particular, antacids, milk, fruit and fruit juices. This is due to the fact that they, while ingestion may affect the efficiency of De Nol.
Overdose
Overdosing drug induced prolonged intake of doses exceeding recommended may cause renal dysfunction. These symptoms are completely reversible when canceling De-Nol.
When the poisoning symptoms the drug should be gastric lavage, use activated charcoal and saline laxatives. Subsequently, treatment should be symptomatic. In the case of impaired renal function, accompanied by high levels of bismuth in plasma, it is possible to enter the complexing agents – dimerkaptoyantarnuyu and dimerkaptopropansulfonovuyu acid. In the case of the expressed human kidney hemodialysis shown.
pharmachologic effect
Pharmacological group:
Intestinal antiseptic and astringent.
Pharmacodynamics:
Antiulcer agent with antibacterial activity against Helicobacter pylori. Also has anti-inflammatory and astringent. In the acidic environment of the stomach precipitated insoluble bismuth oxychloride and citrate chelated compound formed from a proteinaceous substrate a protective film on the surface of ulcers and erosions. By increasing the synthesis of prostaglandin E, mucus secretion and bicarbonate, stimulates activity of cytoprotective mechanisms increases resistance mucosa of the gastrointestinal tract to the action of pepsin, hydrochloric acid, enzymes and bile salts. Leads to the accumulation of epidermal growth factor in the defect area. Reduces the activity of pepsin and pepsinogen.
Pharmacokinetics:
Bismuth subcitrate is practically not absorbed from the gastrointestinal tract. It appears mainly faeces. A minor amount of bismuth, received by the plasma is excreted by the kidneys.
Conditions of supply of pharmacies
Without recipe.
side effects
From the digestive system: may cause nausea, vomiting, more frequent stools, constipation. These phenomena are not dangerous to health and are temporary in nature. Allergic reactions: skin rash, itchy skin.
With prolonged use at high doses – encephalopathy associated with the accumulation of bismuth in the CNS.
special instructions
The drug should not be used more than 8 weeks. It is also not recommended during treatment exceed the daily dose for adults and children. During treatment
De nolom should not be used other drugs containing bismuth. Upon completion of a course of treatment at the recommended doses of active principle concentration in blood plasma does not exceed 3-58 g / l, and the toxicity is observed only at concentrations above 100 g / l.
In the application of De Nol possible staining of feces in a dark color due to the formation of bismuth sulphide. Sometimes there is a slight darkening of the tongue.
Storage conditions
Store at a temperature not higher than 25 C.
Keep out of the reach of children.
Dosing and Administration
Adults and children over 12 years of drug prescribed 1 tablet 4 times a day 30 minutes before meals and at bedtime or 2 tablets 2 times a day 30 minutes before meal.
Children from 8 to 12 years of drug prescribed 1 tablet 2 times a day for 30 minutes before eating.
To children of 4 to 8 years: administered in a dose of 8 mg / kg / day; the daily dose is divided into 2 doses. Take 3 minutes before a meal.
Tablets need to drink some water.
The duration of treatment of 4-8 weeks. Over the next 8 weeks, should not be applied preparations containing bismuth.
For eradication of Helicobacter pylori advisable to use De-Nol in combination with other antibacterial agents with Helicobacter activity.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist