Dalatsin 1% gel 30g tuba

$26.00

Dalatsin 1% gel 30g tuba

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SKU: 01333989616 Categories: , , Tag:

Description

Composition
Active substance:
Composition (per 1 g of gel): active ingredient clindamycin (as clindamycin phosphate) 10 mg ;.
Excipients:
Composition (per 1 g of gel): Excipients: allantoin 2 mg, 3 mg methylparaben, propylene glycol, 50 mg, 100 mg of polyethylene glycol, carbomer 934P 7,5 mg, 40% sodium hydroxide solution q.s., purified water q.s. up to 1 year
Description:
Clear, colorless, viscous mass.
Product form:
Gel for external application of 1%.
Initial: 30 g gel tube of layered material consisting of low density polyethylene, high density polyethylene, aluminum foil, an ethylene copolymer.
Secondary: 1 tube with instructions for use in a cardboard package.
Contraindications
– hypersensitivity to clindamycin or lincomycin history. – in patients with antibiotic-associated colitis in history. – up to age 12 years (Safety and efficacy data are not available).
Dosage
1 %
Indications
Acne vulgaris.
Interaction with other drugs
There is cross-resistance of microorganisms to clindamycin and lincomycin.
antagonism was observed between clindamycin and erythromycin.
It is found that clindamycin in systemic administration gives neuromuscular transmission and thus may enhance the action of other peripherally acting muscle relaxants, and the drug should be used with caution in patients receiving drugs of this group.
pharmachologic effect
Pharmacological group:
Lincosamide antibiotic.
Pharmacodynamics:
Clindamycin phosphate is inactive in vitro, but after application to the skin rapidly hydrolyzed phosphatases in the ducts of the sebaceous glands to form clindamycin having antibacterial activity. Shows the sensitivity of all tested strains of Propionibacterium acnes to clindamycin in vitro (MIC 0.4 ug / ml).
After application to the skin of clindamycin free fatty acids on the skin surface is reduced from about 14% to 2%.
Pharmacokinetics:
After the external application of 1% clindamycin phosphate gel in serum and in urine are determined by very low concentrations of clindamycin.
Shows the activity of clindamycin in comedones in patients with acne vulgaris. The average concentration of the antibiotic in comedone content after application of clindamycin solution in isopropyl alcohol and water (10 mg / ml) for 4 weeks, an average of 597 ug / g Content comedo (0-1490 ug / g).
Use in elderly patients
In clinical studies did not include sufficient numbers of patients aged over 65 years, it was possible to evaluate whether there are differences in the pharmacokinetics in elderly patients compared to younger.
Pregnancy and breast-feeding
In animal studies, when administered subcutaneously or clindamycin inwardly fertility impairment, as well as any adverse effects on the fetus is not detected, except the drug in doses that are toxic to the mother. Results from animal studies can not always be extrapolated to humans. In clinical studies with systemic administration of the drug to women during the second and third trimester of pregnancy, no marked increase in the incidence of congenital anomalies of the fetus. Studies of the drug in women during the first trimester of pregnancy has not been carried out. The drug should be used during pregnancy only if the expected benefit to the mother outweighs the potential risk to the fetus.
It is not known whether clindamycin is released in breast milk after topical application. Clindamycin found in breast milk after oral or parenteral administration, however during breastfeeding must either cancel the use of the drug or to discontinue breastfeeding, given the degree of importance of the drug to the mother.
Conditions of supply of pharmacies
Without recipe.
side effects
Violations of the skin and subcutaneous tissue disorders:
Skin irritation, dry skin, hives – very often (> 1/10);
Seborrhea – common (> 1/100 and
Contact dermatitis * – Frequency not known (can not be determined on the basis of available data).
Disorders of the gastrointestinal tract:
Digestive disorders – common (> 1/100 and
Pseudomembranous colitis *, abdominal pain * – Frequency not known (can not be determined on the basis of available data).
Violations by the organ of vision:
Eye pain * – Frequency not known (can not be determined on the basis of available data).
Infectious and parasitic diseases:
Folly kulit * – Frequency not known (can not be determined on the basis of available data).
*: Adverse reactions recorded during post-marketing use of the drug.
If any of these instructions side effects are compounded, or observed any other side effects not mentioned in the instructions, you should immediately inform your doctor.
When applied topically, clindamycin can be absorbed in amounts that cause systemic effects. The possible systemic side effects include diarrhea, hemorrhagic diarrhea, including pseudomembranous colitis.
In case of overdose shown holding symptomatic and supportive therapy.
special instructions
Avoid exposure of the drug to the mucous membrane of the eyes and mouth. After applying the gel to thoroughly wash your hands. Accidental contact with sensitive surfaces (eyes, skin abrasions, mucous membranes) should be given area, rinse with cool water.
The use of clindamycin (and other antibiotics) orally or parenterally, in some cases associated with the development of severe diarrhea and pseudomembranous colitis. With topical clindamycin cases of diarrhea and colitis are rare, however, caution should be exercised, and to conduct appropriate diagnostic and therapeutic measures drug severe or prolonged diarrhea should be abolished in the development and, if necessary. Typically, onset of diarrhea, colitis and pseudomembranous colitis is marked within a few weeks after the oral or parenteral treatment of clindamycin. In the case of severe diarrhea should decide whether colonoscopy. Purpose drugs that reduce the motility of the gastrointestinal tract such as opioid analgesics and diphenoxylate with atropine may prolong and / or worsen this complication. It was found that vancomycin is effective against antibiotic-associated pseudomembranous colitis caused by Clostridium Difficile. The usual dose, divided in 3-4 administration to adults is from 500 mg to 2 g of vancomycin per day orally for 7-10 days.
Effects on ability to drive a car, and management mechanisms:
There is no reason to believe that use of the drug Dalatsin may affect the ability to drive a car, and management mechanisms.
Storage conditions
At a temperature not higher than 25 oC, the reach of children. Do not freeze.
Dosing and Administration
Outwardly. A thin layer of gel is applied to the affected area clean, dry skin 2 times per day.
The course of treatment to obtain satisfactory results, treatment should be continued for 6-8 weeks and can be extended to 6 months if necessary. If, after using the drug for several months of treatment efficacy is reduced, it is necessary to make a break of 4 weeks.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

Pfizer

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