Coldrex maksigripp powder pack. 10 pcs lemon

Description

Composition
Active substance:
1 sachet contains: paracetamol 1000 mg,
Phenylephrine Hydrochloride 10 mg
ascorbic acid 40 mg
Excipients:
Sucrose – 3725 mg citric acid – 680 mg Sodium citrate – 430 mg, corn starch – 200 mg, flavor Lemon – 200 mg Sodium Cyclamate – 79 mg Sodium saccharinate – 54 mg, colorant curcumin (E100) – 7 mg colloidal silicon dioxide – 2 mg.
Description:
Powder for solution for oral administration (lemon) of light yellow color, with a lemon odor; prepared solution turbid, yellowish-green color, with lemon smell, no surface scum and solids.
Product form:
By 6.427 grams in multilayer bags (paper / aluminum foil / polyethylene). 10 bags together with instructions for use placed in a cardboard box.
Contraindications
– increased sensitivity to the drug; – severe liver disease; – severe kidney disease, – disorders of the hemopoietic system, – thyrotoxicosis; – hypertension – heart disease (expressed aortic stenosis, acute myocardial infarction, tachyarrhythmia) – prostatic hyperplasia; – closure glaucoma, – diabetes, – diseases associated with hereditary malabsorption of sugars as each packet contains 4 g of saccharose, – a genetic absence of glucose-6-phosphate dehydrogenase; – deficit sucrase / isomaltase, fructose intolerance, glucose-galactose malabsorption, since The preparation includes sucrose; – simultaneous reception of tricyclic antidepressants, beta-blockers, MAO inhibitors and up to 14 days after their withdrawal; – pregnancy – lactation (breastfeeding) – childhood and adolescence to 18 years.
Indications
Elimination of cold and flu symptoms: – increased body temperature; – headache – chills – pain in joints and muscles – nasal congestion – throat pain – pain in the sinuses.
Interaction with other drugs
Paracetamol at reception for a long time increases the effect of anticoagulants (warfarin and other coumarin), which increases the risk of bleeding. Episodic receiving a single dose of the drug has no significant influence on the effect of indirect antikoagulyantov.Induktory microsomal oxidation enzymes in the liver (barbiturates, phenytoin, carbamazepine, rifampicin, AZT, phenytoin, ethanol, flumetsinol, phenylbutazone and tricyclic antidepressants) increase the risk of hepatotoxicity with overdoses and simultaneous reception with paratsetamolom.Ingibitory microsomal oxidation (cimetidine) reduce the risk of hepatotoxicity deystviya.Paratsetamol reduces efficiency Diouri ble preparatov.Metoklopramid and domperidone is increased, and reduces the rate of absorption colestyramine paratsetamola.Paratsetamol MAO inhibitors enhances effects, sedation, etanola.Fenilefrin when taken with MAO inhibitors may increase AD.Fenilefrin reduces the effectiveness of beta-adrenergic blockers and antihypertensive drugs, increases the risk of hypertension and disorders of the cardiovascular sistemy.Odnovremennoe use of phenylephrine with sympathomimetic amines and can increase the risk of side effects from cardiovascular sistemy.Tritsiklicheskie antidepressants increase the sympathomimetic effects of phenylephrine may increase the risk of side effects from cardiovascular sistemy.Odnovremennoe use of halothane with phenylephrine increases the risk of ventricular aritmii.Fenilefrin reduce the hypotensive effect of guanethidine which, in turn, increases the activity of alpha-adrenostimuliruyuschee fenilefrina.Antidepressanty, protivoparkinsonicheskogo agents, antipsychotics, phenothiazine derivatives increase the risk of urinary retention, dry mouth, zaporov.Odnovremennoe assignment GCS with phenylephrine increases the risk of glaukomy.Pri applied simultaneously with cardiac glycosides digoxin and may increase the risk of cardiac arrhythmias or heart pristupa.Askorbinovaya acid increases the risk of crystalluria in the treatment of salicylates and sulfonamides short-acting, slow renal excretion of acid, increases in conducting drugs having an alkaline reaction (including alkaloids), reduces blood levels of oral kontratseptivov.Etanol promotes acute pankreatita.Mielotoksichnye medicaments amplify manifestation gematotoksichnosti drug.
Overdose
In the case of drug overdose Koldreks® MaksGripp (even with a good state of health) should take into account the risk of serious damage delayed symptoms caused pecheni.Peredozirovka usually paracetamol. Liver damage in adults may upon receipt> 10 g paratsetamola.Priem> 5 g of acetaminophen can cause liver damage in patients who have the following risk factors: -Duration treatment with carbamazepine, phenobarbital, phenytoin, primidone, rifampicin, Hypericum perforatum drugs, or other agents stimulating liver enzymes;-regular alcohol in excess amounts; -defitsit glutathione (due to eating disorders, cystic fibrosis, HIV infection, starvation, exhaustion) .Simptomy (due s paracetamol) for 24 hours are possible paleness of the skin, nausea, vomiting, anorexia, abdominal pain; for 12-48 hours can manifest signs of liver disease, signs of impaired glucose metabolism and metabolic acidosis. In case of severe poisoning can develop severe liver failure until liver encephalopathy, coma and death. Acute renal failure with acute tubular necrosis, which is diagnosed by severe pain in the lumbar region, hematuria and proteinuria, may develop without severe hepatic dysfunction. There are reports of cardiac arrhythmias and pancreatitis overdose paratsetamola.V early period of symptoms may be limited to nausea or vomiting and may not reflect the degree of the severity of overdose or the risk of internal injury organov.Lechenie: within the first hour after the alleged overdose expedient appointment of activated carbon inside. After 4 hours or more after the intended overdosing is necessary to determine plasma concentrations of paracetamol (acetaminophen earlier determination of concentration can be misleading). The antidote is acetylcysteine. acetylcysteine ​​treatment may be up to 24 hours after ingestion of paracetamol, however, the maximum hepatoprotective effect can be obtained for the first 8 hours after the overdose. After that, the effectiveness of antidote drops sharply. may be administered in case of necessity acetylcysteine ​​/ in. In the absence of emesis alternative embodiment (without the possibility of quick inpatient care) is the designation methionine inside. Treatment of patients with severe hepatic dysfunction at 24 hours after ingestion of paracetamol should be carried out together with specialists poison center or specialized separation diseases pecheni.Pri first sign of overdosing is necessary to immediately seek medical help, even in the absence of symptoms distinct otravleniya.Simptomy due phenylephrine irritability , headache, dizziness, insomnia, increased blood pressure, nausea, vomiting, irritability, reflex bradika Diya. In severe cases an overdose may develop hallucinations, confusion, seizures, arrhythmias. Overdosing phenylephrine can cause symptoms similar to side deystviem.Lechenie: symptomatic therapy, with severe hypertension use of alpha-adrenergic blockers, such as ascorbic acid due fentolamin.Simptomy: The use of more than 1 g – headache, increased CNS excitability, insomnia, nausea , vomiting, diarrhea, gastritis hyperacid, damage to the gastrointestinal mucosa, inhibition of pancreatic insular apparatus function (hyperglycemia glyugokozuriya), hyperoxaluria, nephrolithiasis (and of calcium oxalate), renal glomerular damage the apparatus, decrease capillary permeability (possible deterioration of tissue trophism, increased blood pressure, hypercoagulation, development of microangiopathy) .Askorbinovaya acid in high doses (3000 mg) can cause osmotic diarrhea, and the temporary disruption of the gastrointestinal tract, such as nausea, discomfort in the zheludka.Proyavleniya overdose ascorbic acid can be categorized as those which are caused by severe liver disease resulting from overdose paratsetamola.Lechenie: sim -automatic, forced diuresis.
pharmachologic effect
Pharmacological group:
N02BE51
Pharmacodynamics:
Combined means whose action is due to its constituent komponentami.Paratsetamol is an analgesic and antipyretic agent. Its mechanism of action is presumed the suppression of prostaglandin synthesis, preferably in the central nervous sisteme.Paratsetamol it has an extremely small influence on prostaglandin synthesis in peripheral tissues, it does not change the water and electrolyte metabolism and does not damage the mucosa of the gastrointestinal tract. This paracetamol property makes the drug particularly suitable for patients with diseases of the gastrointestinal tract in history (e.g., patients with gastrointestinal bleeding history or elderly patients) or in patients receiving concomitant drug treatment, in which the suppression of the synthesis of peripheral prostaglandins may be undesirable. phenylephrine hydrochloride – sympathomimetic agent, whose action is directed to stimulation of adrenergic receptors (alpha advantageously adrenoretse tori), which reduces the swelling of the nasal mucosa and nasal relief dyhaniya.Askorbinovaya acid (vitamin C) compensates for the increased need for vitamin C at a “cold” and flu, particularly in the initial stages of the preparation zabolevaniya.Vhodyaschie components do not cause drowsiness and do not break concentration.
Pharmacokinetics:
ParatsetamolBystro and almost completely absorbed from the gastrointestinal tract, the distribution in the body fluids relative ravnomerno.Metaboliziruetsya predominantly in the liver with the formation of several metabolitov.T1 / 2 for receiving a therapeutic dose amounts to 2-3 hours. The main amount of the drug is excreted after conjugation in the liver. In unaltered allocated not more than 3% of the administered dose is absorbed from the gastrointestinal tract paratsetamola.FenilefrinPloho and undergoes metabolism in the “first pass” in the intestine and liver by MAO. When receiving phenylephrine inwardly bioavailability ogranichena.Vyvoditsya urine almost entirely in the form of a conjugate sulfuric kisloty.Askorbinovaya kislotaHorosho absorbed from the gastrointestinal tract, binding to plasma proteins – 25%. Distribution in the body tissues shirokoe.Metaboliziruetsya in liver is excreted in the urine as unchanged oxalate and acid vide.Askorbinovaya adopted in excessive amounts, rapidly excreted unchanged in the urine.
Pregnancy and breast-feeding
BeremennostPreparat should not be used during pregnancy without first consulting your doctor!
In studies conducted in animals and humans, it did not reveal any risk of the use of paracetamol during pregnancy or negative effects on intrauterine development ploda.Dostatochnye data on the effect of drugs containing phenylephrine, on pregnancy otsutstvuyut.Maksimalnaya daily dose of ascorbic acid during pregnancy is 2,000 mg, which is significantly more than the maximum daily dose of the drug, so the drug in pregnant women allegedly without risk of side x effects from ascorbic kisloty.Period thoracic vskarmlivaniyaPreparat should not be used during breast-feeding without first consulting your doctor!
Paracetamol crosses the placental barrier and into breast milk. In studies conducted in humans has not been identified any negative effects on the baby during breast vskarmlivanii.Fenilefrin can penetrate into breast moloko.Maksimalnaya daily intake of ascorbic acid during breastfeeding is 2000 mg, which is significantly higher than the maximum daily dose, therefore the drug in women during breastfeeding is not conjugate with the occurrence of side effects from ascorbic acid.
Conditions of supply of pharmacies
Without recipe
side effects
Determining the frequency of side effects: very common (> 1/10), common (> 1/100 and
special instructions
The patient should be informed that if symptoms persist after 5 days of use of the drug should stop taking it and consult with vrachom.Preparat should be taken only at the recommended dozah.Preparat should not be taken concomitantly with other drugs containing acetaminophen, as well as other narcotic analgesics (metamizole sodium), NSAIDs (aspirin, ibuprofen), barbiturates, anticonvulsant drugs, rifampicin and chloramphenicol, Symp atomimetikami (such as decongestants, agents that suppress appetite, psychostimulant amphetamine means) with other agents to alleviate the symptoms of colds and grippa.Pri conducting assays for determination of uric acid in blood glucose level the patient should inform the physician of drug application Koldreks® MaksGripp, t .to. preparation may distort the results of laboratory tests that measure the concentration of glucose and uric kisloty.Pered drug intake Koldreks® MaksGripp necessary to consult a physician if: -priema metoclopramide, domperidone (used to eliminate nausea and vomiting) or cholestyramine used to lower blood cholesterol concentrations; -priema medications for reducing blood clotting (e.g., warfarin), – observance of a diet low in sodium – each sachet contains 0.12 g of sodium; -heavy infectious Zab Olevanov (including sepsis) in patients with deficiency of glutathione, as the intake of paracetamol may increase the risk of metabolic acidosis, features which are the violation frequency and depth of breathing, accompanied by a feeling of breathlessness (dyspnea), nausea, vomiting, loss of appetite. If a patient finds a such, you should immediately consult a vrachu.Vo prevent toxic liver injury, paracetamol should not be combined with the admission of alcoholic beverages, as well as to make the persons chronically consume alkogol.Vliyanie on the ability to drive vehicles and mehanizmamiPri reception at the recommended doses, the drug It does not affect the ability to drive vehicles and mechanisms, as well as engage in other potentially hazardous activities that require concentra radio and psychomotor speed reactions. If dizziness is not recommended to drive vehicles or operate machinery.
Storage conditions
The drug should be stored in reach of children at a temperature not higher than 25 ° C.
Dosing and Administration
To receive vnutr.Ne exceed this dose!
Should apply the lowest dose necessary to achieve the effect!
The minimum interval between doses of the drug Koldreks® MaksGripp should be 4 ch.Soderzhimoe one packet put into the mug and pour half cup of hot water. Stir until dissolved. Add cold water, if necessary, and sugar on vkusu.Vzroslye Inside, a single dose – 1 sachet. Repeated application of the drug may not earlier than after 4-6 hours and no more than 4 times / sut.Maksimalnaya daily dose should not exceed 4 paketikov.Maksimalnaya duration of the drug without consultation with a physician is not more than 5 dney.Ne receive simultaneously with other means paratsetamolsoderzhaschimi , decongestants and means to alleviate the symptoms of “cold” and the flu, as well as ethanol-containing media and napitkami.Esli while taking the drug symptoms persist, seek medical advice.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist