Clotrimazole, Glaxo Tab vaginas. 100 mg of 6-Piece

Description

Composition
Active substance:
Clotrimazole 100 mg [101.96 mg given perezakladku about 2%].
Product form:
Vaginal tablets of 100 mg (blisters).
Contraindications
Hypersensitivity menstrual period (for vaginal forms), pregnancy (I term).
Dosage
100 mg
Indications
Fungal skin and mucous membranes dermatomycosis, dermatophytosis, trichophytosis, tinea, mikrosporiya, candidiasis, stomatitis, interdigital fungal erosion, fungal paronychia, fungal infections, complicated secondary pyoderma, candida vulvitis, vulvovaginitis, balanitis, trichomoniasis, pityriasis versicolor, pityriasis versicolor, erythrasma, reorganization of the birth canal before delivery.
Interaction with other drugs
Amphotericin B, nystatin, natamycin reduce the effectiveness of clotrimazole while their application.
pharmachologic effect
Pharmacological group:
Antifungal agent.
Pharmacological properties:
Antifungal, antimicrobial, protivotrihomonadnyh ,.
Pharmacodynamics:
Antifungal agent from the group of imidazole derivatives for topical and local (intravaginal) administration, reduces the synthesis of ergosterol, which is part of the microbial cell membrane wall, and causes a change in its structure and properties. In low concentrations fungistatic effect, and large – fungicide, not only in proliferating cells. The fungicidal concentrations interacts with mitochondrial and peroxidase enzymes, resulting in increased concentrations of hydrogen peroxide up to a toxic level, which also contributes to the destruction of fungal cells. It is active against pathogenic dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), yeasts and fungi (the genus Candida, Torulopsis glabrata, the genus Rhodotorula, Malassezia furfur), agents of multi-colored lichen, erythrasma, Gram-positive (Staphylococcus, Streptococcus, Corynebacterium minutissimum) and Gram-negative bacteria (Bacteroides, Gardnerella vaginalis), Trichomonas vaginalis.
Pharmacokinetics:
Poorly absorbed through the skin and mucous membranes, and almost no systemic action. Is accumulated in the stratum corneum of the epidermis, it penetrates the nail keratin. in the deep layers of the epidermis concentration higher than MIC for dermatophytes. When intravaginal administration absorbed no more than 3-10% of the administered dose. The liver is rapidly metabolized to inactive metabolites. High concentrations in the vaginal secretions and the low concentration in the blood are retained within 48-72 hours.
Conditions of supply of pharmacies
Without a prescription.
side effects
Local reactions burning, swelling, irritation and scaling of the skin, paresthesia, erythematous rash, blisters. Allergic reactions (pruritus, urticaria). The intravaginal administration – itching, burning, redness and swelling of the mucous membranes, vaginal discharge, headache, gastralgia, frequent urination, intercurrent cystitis, burning sensation in the penis to sexual partners, pain during sexual intercourse.
special instructions
simultaneous treatment of sexual partners is necessary to prevent reinfection. In II, III trimester vaginal applicator use is undesirable. If trichomoniasis is recommended to combine the treatment with chemotherapeutic drugs (metronidazole orally). After applying the cream should not impose an occlusive dressing. Avoid contact with eye mucosa. Patients with hepatic insufficiency should periodically monitor liver function. When signs of hypersensitivity or irritation of the treatment was stopped. If there is no effect for 4 weeks should confirm the diagnosis.
Carefully. Lactation.
Dosing and Administration
Outwardly. Cream, ointment, lotion or solution is applied thinly to the affected areas of skin and mucous membranes of 2-3 times a day (3-4 to solution) and gently rubbed. A single dose on a surface area with palm size – column cream 5 mm or 10-20 cap solution. The course of treatment an average of about 4 weeks, at its end (the disappearance of clinical manifestations) advisable to continue treatment for another 14 days. Duration of therapy erythrasma – 2-4 weeks, multi-colored lichen – 1-3 weeks. Before greasing the feet washed with warm soapy water, wipe thoroughly, especially between the toes. Fungal lesions of the feet skin after achieving a therapeutic effect it is recommended to continue treatment for 2-3 weeks. Vaginal cream or gel introduced in portions of 5 g deeply in the vagina 1 time per day for 3 days. When Candida balanitis vulvitis or used 2-3 times per day for 1-2 weeks. Vaginal tablets administered deep into the vagina 500 mg dose, or 200 mg for three days, or 100 mg 6-7 days (1 times a day, in the evening). The course of treatment is usually combined with the treatment of external genital organs of a cream, ointment or solution. If necessary, treatment can be repeated. For readjustment of the birth canal is recommended that a single administration of one tablet. When urethritis carried instillation of 1% solution in the urethra for 6 days.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist