Clotrimazole cream 1% 30g tuba Teva

Description

Composition
Active substance:
100 g of cream contains: Clotrimazole 1.00 g
Excipients:
Benzyl alcohol 2.00 g 2.00 g sorbitan stearate, polysorbate 60, 1.50 g, 3.00 g of cetyl palmitate, cetostearyl alcohol [60% cetyl alcohol, stearyl alcohol 40%] 10.00 g of 2-octyldodecanol 13 50 g purified water 67.00 g
Description:
The homogeneous white cream.
Product form:
Cream for external application of 1%.
To 30 g in an aluminum tube, covered with aluminum foil for controlling the first opening with a screw cap. 1 the tube together with instructions for use placed in a cardboard box.
Contraindications
Hypersensitivity to clotrimazole or adjuvants, I trimester of pregnancy.
Be wary – lactation.
Indications
Fungal diseases of the skin, folds of skin mycoses, stop; pityriasis versicolor, erythrasma, superficial candidiasis, caused by dermatophytes, yeast (including Candida genus), molds and other fungi and pathogens sensitive to clotrimazole; mycoses complicated by secondary pyoderma.
Interaction with other drugs
Amphotericin B, nystatin, natamycin reduce efficiency while applying clotrimazole. When applying the cream negative interactions with other drugs is not known and can not be expected, because clotrimazole resorptive capacity is very low.
Overdose
Apply cream in high doses does not cause any reactions and conditions, life-threatening.
pharmachologic effect
Pharmacological group:
Antifungal agent.
Pharmacodynamics:
Clotrimazole-Teva is an antifungal agent wide spectrum of action for external use. Antifungal effect of clotrimazole active principle (imidazole derivative) is connected with the violation of the synthesis of ergosterol, a component of fungal cell membranes that modifies membrane permeability and cause subsequent lysis of the cells. In low concentrations fungistatic effect, and large – fungicide, not only in proliferating cells. The fungicidal concentrations interacts with mitochondrial and peroxidase enzymes, resulting in increased concentrations of hydrogen peroxide up to a toxic level, which also contributes to the destruction of fungal cells. It is effective against dermatophytes, yeast and molds, as well as the causative agent of multi-colored lichen Pityriasis versicolor (Malazessia furfur) and the pathogen erythrasma. It has antimicrobial action against Gram-positive (staphylococci, streptococci) and Gram-negative bacteria (Bacteroides, Gardnerella vaginalis), as well as against Trichomonas vaginalis. In vitro at a concentration of 0.5-10 ug / ml of clotrimazole inhibits reproduction Corynebacteria family bacteria and gram-positive cocci (except eneterokokkov) and has trihomonatsidnoe action at a concentration of 100 .mu.g / ml.
Pharmacokinetics:
Clotrimazole poorly absorbed through the skin and mucous membranes, and almost no systemic action. The concentration in the deep layers of the epidermis is higher than the minimum inhibitory concentration for dermatophytes. When applied topically clotrimazole concentration in the epidermis is greater than in the dermis and subcutaneous tissue.
Pregnancy and breast-feeding
Clinical and experimental studies, it was found that the use of the drug during pregnancy or while breast-feeding has a negative impact on the health of the woman or the fetus (baby). However, the question of the advisability of the appointment of the drug should be decided individually after consulting a doctor.
Application of the drug directly to the lactating mammary gland is contraindicated.
Conditions of supply of pharmacies
Without recipe.
side effects
Itching, burning, tingling in the field application of the cream, erythema, blistering, swelling, irritation and skin peeling. Allergic reactions (pruritus, urticaria).
special instructions
Not recommended to apply the drug to the skin in the eye area. In the treatment of onychomycosis is necessary to ensure that the treated nail plate was cut short, or have a rough surface for better penetration of the active substance. In these cases, preference should be given to the solution because of better penetrating properties. Patients with hepatic insufficiency should periodically monitor liver function. When signs of hypersensitivity or irritation of the treatment was stopped. If no effect within 4 weeks should confirm the diagnosis.
Storage conditions
Store at a temperature not higher than 25 C.
Keep out of the reach of children!.
Dosing and Administration
Outwardly. The cream is applied a thin layer of 2-3 times a day on precleaned (with soap at a neutral pH) and dry skin lesions and gently rubbed.
The duration of treatment depends on the severity of the disease, the localization of pathological changes and the effectiveness of therapy.
tinea treatment is carried out at least 4 weeks tinea versicolor – 1-3 weeks. Fungal diseases of the skin of the feet is recommended to continue treatment for an additional at least 2 weeks after the elimination of symptoms.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist