Chloramphenicol 500mg tab 20 pc

$2.18

Chloramphenicol 500mg tab 20 pc

Quantity:

Description

Composition
Active substance:
1 tablet contains: 500 mg of chloramphenicol.
Product form:
Tablets of 500 mg.
Contraindications
Hypersensitivity, inhibition of bone marrow hematopoiesis, acute intermittent porphyria, deficiency of glucose-6-phosphate dehydrogenase, liver and / or kidney failure, skin diseases (psoriasis, eczema, fungal), pregnancy, lactation, children under 3 years of age and / or body weight less than 20 kg.
Precautions: Patients who received prior therapy with cytotoxic drugs or radiation therapy.
Dosage
500 mg
Indications
Infections of the urinary and biliary tract, caused by susceptible microorganisms.
Interaction with other drugs
Inhibits enzyme system cytochrome P450, therefore, while the use of phenobarbital, phenytoin, indirect anticoagulants marked attenuation of metabolism of these drugs, slow excretion and increasing their plasma concentrations.
It reduces the antibacterial effect of penicillins and cephalosporins. While the use of erythromycin, clindamycin, lincomycin marked weakening mutual action due to the fact that chloramphenicol can displace these drugs from a bound state or inhibit their binding to the 50S subunit of bacterial ribosomes.
Simultaneous administration with drugs, oppressive blood (sulfonamides, cytostatics) influencing the metabolism in the liver, with radiation therapy increases the risk of side effects.
When administered with oral hypoglycemic drugs marked enhancement of their action (due to the suppression of metabolism in the liver and enhance their concentration in the plasma).
Myelotoxic drugs increase the expression gematotoksichnosti drug.
Overdose
Symptoms: nausea, vomiting. Treatment: gastric lavage, symptomatic therapy, hemosorbtion.
pharmachologic effect
Pharmacological group:
Antibiotic.
Pharmacodynamics:
Bacteriostatic broad spectrum antibiotic, gives the protein synthesis in the microbial cell in step transport of amino acids tRNA on ribosomes.
It is effective against strains of bacteria that are resistant to penicillin, tetracycline, sulfonamides.
It is active against the following microorganisms: Escherichia coli, Shigella dysenteria, Shigella flexneri spp, Shigella boydiispp, Shigellasonnei, Salmonellaspp… (Including Salmonella typhi, Salmonella paratyphi), Staphylococcus spp., Streptococcus spp. (Including Streptococcus pneumoniae), Neisseria meningitidis, Neisseria gonorrhoeae, a number of strains of Proteus spp., Burkholderia pseudomallei, Rickettsia spp., Treponema spp., Leptospira spp., Chlamydia spp. (Including Chlamydia trachomatis), Coxiella burnetii, Ehrlichia canis, Bacteroides fragilis, Klebsiella pneumoniae, Haemophilus influenzae.
No effect on acid-fast bacteria (including Mycobacteriumtuberculosis), anaerobes, methicillin resistant strains of staphylococci, Acinetobacterspp., Enterobacterspp., Serratiamarcescens, indolpolozhitelnye strains Proteusspp., Pseudomonasaeruginosaspp., Protozoa and fungi. Resistance of microorganisms is slow.
Pharmacokinetics:
Upon receiving the communication with the plasma proteins is – 50-60%. The time to reach maximum concentration (TCmax) after reception – 1-3 hr Volume of Distribution -. 0.6-1.0 l / kg. Therapeutic blood concentration is maintained for 4-5 hours after administration. Well into the fluid and tissues of the body. The greatest concentrations are in his liver and kidneys. The bile is detected up to 30% of the administered dose. The maximum concentration (Cmax) in cerebrospinal fluid is determined in 4-5 hours after a single dose and can reach in the absence of inflammation of the meninges 21-50% of the Cmax in the plasma and 45-89% – in the presence of an inflammation of the meninges. Passes through the placental barrier, concentration in serum may be fetal 30-80% of that in maternal blood. It passes into breast milk. The basic amount (90%) is metabolized in the liver. In the intestine under the influence of intestinal bacteria hydrolyze to inactive metabolites.
Displayed in the kidney for 24 hours – 90% (by glomerular filtration – 5-10% unchanged by tubular secretion as inactive metabolites – 80%) through the intestine – 1-3%. The half-life (T1 / 2) in adults – 1.5-3.5 hours with impaired renal function – 3-11 h T1 / 2 h in children with 3.0-6.5 Low output during hemodialysis…
Conditions of supply of pharmacies
On prescription.
side effects
From the digestive system: dyspepsia, nausea, vomiting (the probability of reception is reduced when within 1 h after eating), diarrhea, mucosal irritation of the mouth and pharynx, dermatitis, goiter (suppression of normal microflora).
From the side of hematopoiesis: reticulocytopenia, leukopenia, granulocytopenia, thrombocytopenia, erythropenia; rarely – aplastic anemia, agranulocytosis.
From the nervous system: psychomotor disturbances, depression, confusion, peripheral neuritis, optic neuritis, visual and auditory hallucinations, decreased visual acuity and hearing, headache.
Allergic reactions: skin rash, angioedema.
Other: a secondary fungal infection.
special instructions
Severe complications of the haematopoietic system, usually associated with high doses for a long time.
When simultaneous administration of ethanol development disulfiramopodobnyh reaction (hyperemia of spasm in the stomach and in the stomach, nausea, vomiting, headache, decreased blood pressure, tachycardia, dyspnea).
Storage conditions
Store in a dry, dark place at a temperature not higher than 25 C.
Keep out of the reach of children!.
Dosing and Administration
Inside (for 30 minutes before a meal, and the development of nausea and vomiting – 1 hour after a meal), 3-4 times daily. The single adult dose – 0.25-0.5 g daily – 2 g In severe infections (hospital) may increase the dose up to 4.3 g / day (under the control of the state of the blood, kidney and liver).
Children older than 3 years of age and / or body weight over 20 kg administered at 12.5 mg / kg every 6 hours or 25 mg every 12 hours, if severe infections – 75-100 mg / kg / day (under control serum concentration of the drug).
The average duration of treatment – 8-10 day.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

Russia

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