Carvedilol 25mg tabs 30 pcs ozone

Description

Composition
Active substance:
1 tablet contains: Carvedilol 12.5 and 25 mg.
Product form:
12.5 mg and 25 mg tablets. 10, 30 tablets in blisters of PVC film and aluminum foil printed patent. 10, 20, 30, 40, 50 or 100 tablets per plastic jars for medicaments. One jar or 1, 2, 3, 4, 5 or 10 contour cell packages together with instructions for use placed in a cardboard box (pack) of cardboard.
Contraindications
Hypersensitivity to carvedilol or other ingredients, acute and chronic heart failure decompensation requiring intravenous inotropic agents; clinically significant liver dysfunction; atrioventricular block II-III extent (except in patients with artificial driver heart, bradycardia rhythm (heart rate less than 50 beats / min), sick sinus syndrome (including sinus block) marked hypotension (systolic blood pressure (BP) is less than 85 mm Hg. Art.), cardiogenic shock, bronchospasm and bronchial asthma (a history), age 18 years (effectiveness and safety have not been established), lactose intolerance, lactase deficiency, glucose-galactose malabsorption (the product contains la ktozu).
Dosage
25 mg
Indications
– Hypertension (in monotherapy or in combination with other antihypertensive agents, for example, blockers of the “slow” calcium channel); – Coronary heart disease (including patients with unstable angina and silent myocardial ischemia); – Chronic heart failure (in a combination therapy).
pharmachologic effect
Pharmacological group:
Alpha- and beta-blockers. ATC code S07AG02.
Pharmacological properties:
Blocks alpha 1, beta1- and beta2-adrenergic receptors.
It has vasodilating, antianginal and antiarrhythmic action. Carvedilol is a racemic mixture of R (+) and S (-) stereoisomers, each of which has the same alpha-adrenoceptor blocking and antioksidantnymisvoystvami.
Beta-adrenoceptor blocking effect of carvedilol is nonselective nature and due laevorotatory S (-) stereoisomer. The drug does not own sympathomimetic activity, has membrane stabilizing properties. Vasodilator effect is mainly due to the blockade of alpha1-adrenoceptor. Due vasodilation decreases total peripheral vascular resistance (SVR). The combination of vasodilation and beta blockade causes the following effects: patients with hypertension lowering blood pressure (BP) is not accompanied by an increase in peripheral vascular resistance without decreasing peripheral bloodstream (in contrast to beta-blockers). Heart rate (HR) decreased slightly. In patients with coronary heart disease has antianginal effects. Reduces pre- and afterload on the heart. It does not have a pronounced effect on lipid metabolism, and the content of potassium ions, sodium and magnesium in the blood plasma. In patients with impaired left ventricular function and / or heart failure, favorably influences hemodynamics and improved ejection fraction and left ventricular size. It has an antioxidant effect, removing oxygen free radicals. Carvedilol reduced mortality and reduced hospitalization rates, reduces symptoms and improves left ventricular function in patients with chronic heart failure of ischemic and non-ischemic origin. carvedilol effects are dose dependent.
Conditions of supply of pharmacies
Prescription.
Dosing and Administration
Inside, drinking plenty of fluids. Hypertension initial dose is 12.5 mg 1 time per day in the first two days of treatment. Then 25 mg 1 time per day. Possibly a gradual increase in the dose at intervals of at least 2 weeks. When failure antihypertensive effect after 2 weeks of therapy, the dose can be increased by 2 times. The maximum recommended daily dose is 1 to 50 mg once daily (possibly divided by 2 Hour). Ischemic heart disease, angina initial dose is 12.5 mg 2 times a day during the first two days of treatment. Then 25 mg 2 times a day. When failure antianginal effect after 2 weeks of therapy, the dose can be increased by 2 times. The maximum recommended daily dose is 100 mg per day, divided into 2 Hour. Chronic heart failure Dose picked individually, under the close supervision of a physician. The recommended starting dose of 3.125 mg (use of carvedilol drug at a dose of 6.25 mg Valium), 2 times a day for 2 weeks. With good tolerability increase dose at intervals of at least 2 weeks to 6.25 mg (1/2 tablet 12.5 mg), 2 times a day, then to 12.5 mg 2 times a day, then – to 25 mg 2 times per day. The dose should be increased to a maximum, which is well tolerated by patients. When a body weight less than 85 kg – maximum dose is 25 mg 2 times a day, with a weight of 85 kg – 50 mg 2 times a day. If the treatment is interrupted for more than 2 weeks, then resuming its starting to dose 3.125 mg (use of carvedilol drug at a dose of 6.25 mg Valium), 2 times a day, followed by increasing doses. In patients with moderate and severe renal impairment, dose adjustment of carvedilol is not required. Carvedilol is contraindicated in patients with clinical manifestations of liver dysfunction.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist