Cardura 4mg tab 30 pc

$18.13

Cardura 4mg tab 30 pc

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SKU: 1427787884 Categories: , Tags: ,

Description

Composition
Active substance:
1 tablet contains: Doxazosin mesylate 1.213 mg / 2.430 mg / 4.850 mg (equivalent to 1 mg, 2 mg, 4 mg of doxazosin).
Excipients:
Tablets 1 mg and 2 mg: 1.200 mg sodium carboxymethyl starch, lactose monohydrate 40.000 mg microcrystalline cellulose 76.382 mg / 75.170 mg magnesium stearate 1.080 mg, 0.120 mg sodium lauryl sulfate. 4 mg tablets: sodium carboxymethylstarch 2.400 mg Lactose monohydrate 80.000 mg microcrystalline cellulose 150.350 mg magnesium stearate 2.160 mg, 0.240 mg sodium lauryl sulfate.
Description:
Tablets 1 mg – white, round, biconvex on one side – the engraving CN 1, on the other side – engraving logo Pfizer.
Tablets 2 mg – white oval, biconcave, on one side – the engraving CN 2 and risk on the other side – engraving logo Pfizer.
4 mg Tablets – white, rhomboid, biconcave, on one side – the engraving CN 4 and risk on the other side – engraving lotto Pfizer.
Product form:
Tablets 1, 2, 4 mg.
At 7, 10 or 14 tablets from a blister Al / PVC. 2 blisters of 7 tablets 1 blister 14 tablets or 3 blisters with 10 tablets together with instructions for use in a cardboard package. .
Contraindications
– increased sensitivity to quinazolines, doxazosin or any of the auxiliary components of the formulation; – lactase deficiency, lactose intolerance, glucose-galactose malabsorption; – the age of 18; – severe hepatic impairment due to the lack of experience with this category of patients; – urinary tract infections; – anuria; – progressive renal failure; – hypotension, and a tendency to orthostatic disturbances (including history); – related obstruction of the upper urinary tract; – bladder stones.
Carefully
The mitral and aortic stenosis, cardiac failure with an increase in minute ejection, right ventricular failure due to pulmonary embolism or exudative pericarditis, left ventricular failure with low filling pressure, cerebrovascular disease, advanced age, the simultaneous application of phosphodiesterase inhibitors of type 5 (PDE-5 ) since symptomatic hypotension may occur, hepatic failure. .
Dosage
4 mg
Indications
– benign prostatic hyperplasia; – for the treatment of delay urine outflow and symptoms associated with BPH; – arterial hypertension (in a combination therapy). .
Interaction with other drugs
The combined use of the drug cardura with PDE5 inhibitors in some patients may result in symptomatic hypotension (see. “Special instructions” section).
Large (% 98) part of doxazosin in plasma associated with proteins. Results of the study of human plasma in vitro indicate that doxazosin has no effect on protein binding of digoxin, warfarin, phenytoin or indomethacin. In clinical practice the drug cardura used without any indication of interaction with thiazide diuretics, furosemide, beta-blockers, antibiotics, hypoglycemic agents for oral administration, uricosuric agents and anticoagulants.
Nonsteroidal anti-inflammatory drugs (especially indomethacin), estrogens and sympathomimetic drugs can reduce the antihypertensive effect of doxazosin.
Doxazosin, eliminating the effects of alpha-adrenostimuliruyuschee epinephrine may lead to the development of hypotension and tachycardia.
When concomitantly with sildenafil for treating pulmonary hypertension increases the risk of orthostatic hypotension.
For a single application of the drug cardura to 1 mg per day for 4 days while taking 400 mg of cimetidine, 2 times a day, there was a 10% increase of average values ​​of AUC and statistically significant increase in mean Cmax (maximum plasma concentration) and medium the half-life of doxazosin. This 10% increase in mean AUC values ​​doxazosin in patients receiving cimetidine is within the variability of the oscillations (27%) average AUC values ​​for doxazosin in comparison with placebo.
When applied simultaneously with other antihypertensives increases the severity of their action (dose required correction).
Do not take simultaneously with other blockers, alpha-adrenergic receptors.
While the use of inducers of microsomal oxidation in the liver may increase the efficiency of doxazosin and inhibitors – decrease. .
Overdose
Symptoms: marked reduction of blood pressure, sometimes accompanied by fainting.
Treatments: you must immediately put the patient on his back and lift his legs, a symptomatic therapy if necessary. Doxazosin binding to plasma proteins is high, therefore, dialysis is not effective.
pharmachologic effect
Pharmacological group:
Alpha1-blocker.
Pharmacodynamics:
Benign prostatic hyperplasia
Purpose of doxazosin in patients with symptomatic benign prostatic hyperplasia (BPH) leads to a significant improvement in performance and reduction urodynamics manifestations of disease symptoms. This action of the drug associated with the selective blockade of alpha1-adrenoceptors located in the stroma and prostatic capsule, bladder neck.
It proved that doxazosin is an effective blocker of 1A subtype of alpha 1-adrenoceptors which constitute approximately 70% of all subtypes of alpha1-adrenoceptors located in the prostate gland. This explains its action in patients with BPH.
Supportive treatment effect of doxazosin and its proven safety of long-term use of the drug (eg. Up to 48 months).
Arterial hypertension
The use of doxazosin in hypertensive patients results in a significant decrease in blood pressure (BP) by decreasing total peripheral vascular resistance. The appearance of this effect is attributed to the selective blockade of alpha1-adrenoceptors located in the vascular network. Before the drug once a day 1 clinically significant antihypertensive effect lasts for 24 hours, blood pressure is reduced gradually; maximal effect is usually observed after 2-6 hours after ingestion of the drug. In hypertensive patients with blood pressure in the treatment with doxazosin was similar in position “lying” and “standing”.
It is noted that in contrast to the non-selective alpha1-blocker doxazosin with long-term treatment of tolerance to the drug did not develop. When carrying out maintenance therapy increase in plasma renin activity of blood and tachycardia are rare.
Doxazosin has a beneficial effect on blood lipid profile, increasing considerably high density lipoprotein ratio to the total content of cholesterol and significantly reducing the overall triglycerides and total cholesterol. In this regard, he has an advantage over diuretics and beta-blockers, which are not affected favorably on these parameters. Given the established relationship of hypertension and blood lipid profile with coronary heart disease, normalization of blood pressure and lipid concentrations in patients receiving doxazosin lead to a reduction in the risk of coronary heart disease.
It has been observed that treatment of doxazosin resulted in the regression of left ventricular hypertrophy, inhibition of platelet aggregation, and enhance the activity of tissue plasminogen activator. Furthermore, it was found that doxazosin improves insulin sensitivity in patients with impaired glucose tolerance.
Doxazosin has no adverse metabolic effects and can be used in patients with asthma, diabetes, left ventricular failure and gout.
Studies in vitro have shown antioxidant 6 ‘and 7’ – gidroksimetabolitov doxazosin in a concentration of 5 micromolar.
In controlled clinical trials conducted in patients with arterial hypertension, doxazosin treatment was associated with improvement erektilnoy function. In addition, patients treated with doxazosin, the newly emerged erectile dysfunction were observed less frequently than in patients treated with angigipertenzivnye means.
Pharmacokinetics:
After oral administration at therapeutic doses doxazosin well absorbed; its concentration in the blood reaches a maximum after approximately 2 hours.
Doxazosin approximately 98% bound to plasma proteins.
The primary metabolic pathways are doxazosin O-demethylation and hydroxylation.
Withdrawal of blood plasma is biphasic with a finite half-life of 22 hours, allowing the drug to assign 1 time per day. Doxazosin undergoes biotransformation active; only less than 5% of the dose is excreted unchanged.
Use in special patient groups
According to pharmacokinetic studies in elderly patients and patients with renal insufficiency The pharmacokinetics of the drug is not significantly different from that of patients of younger age with normal renal function.
There are only limited data from patients with impaired liver function, and the effect of drugs that can alter hepatic metabolism (eg cimetidine). In a clinical study in 12 patients with mild liver dysfunction accompanied by a single application of doxazosin increase in the area under the curve “concentration-time» (AUC) and 43% reduction in the true oral clearance by 40%. Care must be taken when assigning doxazosin, as well as other drugs, bistransformatsii completely exposed in the liver in patients with impaired liver function (see. The section “special instructions”). .
Pregnancy and breast-feeding
Although animal studies the drug has no teratogenic, but when it is used in extremely high doses decreased fetal survival was observed. These doses are approximately 300 times higher than the maximum recommended human dose. Due to the lack of adequate well-controlled studies in pregnant or nursing women, the safety of the use of cardura drug during pregnancy or lactation has not been established. Therefore, during pregnancy or during lactation cardura drug it can only be used while when the physician’s judgment, the potential benefit to the mother outweighs the potential risk to the fetus or child.
Conditions of supply of pharmacies
On prescription.
side effects
The frequency of adverse reactions represented by the following classification: very chastye-> 10% chastye-> 1%, and
special instructions
Postural hypotension / syncope
As with the treatment of any alpha-blockers, especially early in therapy, have very small percentage of patients showed postural hypotension, dizziness and exhibit weakness or loss of consciousness (syncope) (see. The section “Method of administration and dose”). Before the start of the designation of any alpha-blocker, the patient must notify the way to avoid the symptoms of postural hypotension, in particular to refrain from rapid change in body position. At the beginning of treatment, patients should cardura to advise on the need for caution in the case of weakness or dizziness.
Cardura drug should be used with caution in elderly patients because of the possibility of orthostatic hypotension. With age, the risk of occurrence of dizziness, blurred vision and fainting.
The patient should be informed about the increased risk of orthostatic hypotension with the use of alcohol, prolonged standing or performing exercise and in hot weather.
Benign prostatic hyperplasia
In patients with BPH medication can be given both in the presence of hypertension and with normal blood pressure. In applying the drug in patients with BPH with normal blood pressure change of the last immaterial. In this combination in patients with hypertension and BPH can be applied in monotherapy.
Before therapy of prostatic hyperplasia is necessary to exclude its malignant degeneration.
Doxazosin has no effect on the concentration of prostate-specific antigen (PSA) in the blood plasma.
Intraoperative atonic iris syndrome
Intraoperative atonic iris syndrome (a variant of the narrow pupil syndrome) has been observed in some patients during cataract surgery, which is prepared or treated with alpha 1-blockers. Since intra-atonic iris syndrome can lead to more frequent complications during surgery, it is necessary to warn the operating surgeon that the alpha 1-blockers are taken at this point or taken to the earlier operation.
The combined use with PDE5 inhibitors
Care must be taken when used together cardura preparation with PDE-5 inhibitors, as some patients may result in symptomatic hypotension.
Abnormal liver function
Care should be taken when administering the drug cardura, as well as other drugs, completely exposed biotransformation in the liver in patients with impaired liver function (see. The section “Pharmacokinetics”), avoiding the destination maximum doses.
Effect on the driving ability and use of equipment
During the period of treatment must be careful when driving and busy with other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Incompatibility
Unknown. .
Storage conditions
In a dry place, protected from light at a temperature not higher than 30 C.
Keep out of the reach of children. .
Dosing and Administration
Cardura drug can be administered in the morning and evening, and is intended for oral administration.
Benign prostatic hyperplasia
The recommended starting dose of the drug is cardura 1 mg 1 time per day in order to minimize the possibility of postural hypotension and / or syncope (fainting) (see. The section “Special instructions”). Depending on the individual characteristics and availability urodynamics indices BPH symptoms the dose can be increased to 2 mg, and later 4 mg and up to a maximum recommended dose of 8 mg. The recommended range for dose escalation is 1-2 weeks. Typically, the recommended dose is 1 mg 2-4 times a day.
Arterial hypertension
The dosage varies from 1 to 16 mg / day. Treatment is recommended to start with 1 mg 1 time per day for 1 or 2 weeks in order to minimize the possibility of postural hypotension and / or syncope (fainting) (the phenomenon of “first dose”) (see. The section “Specific guidance” ). After the first dose the patient needs monitoring of blood pressure for 6-8 hours. This is required in connection with the development of the phenomenon of “first dose” is particularly pronounced on the background of the previous diuretics.
During the next 1 or 2 weeks, the dose can be increased to 2 mg 1 time per day. To achieve the desired reduction in blood pressure, if necessary, the daily dose should be increased gradually, keeping regular intervals up to 4 mg, 8 mg and to a maximum – 16 mg depending on the severity of the patient’s response to the drug. Usually, the dose is 1 mg 2-4 times a day.
If therapy is added to a diuretic or other antihypertensive agent is necessary to adjust the dose of the drug cardura depending on the patient’s condition with further titration under a physician’s supervision.
If cardura drug therapy was interrupted for a few days, to resume use of the preparation should be from the initial dose.
Use in elderly patients
dose adjustment is not required.
The use in renal failure
Doxazosin pharmacokinetics in patients with renal insufficiency does not change, and the drug does not impair the existing renal dysfunction, however in such patients it is used in conventional doses.
Application of hepatic insufficiency
Care must be taken (see. “Special Instructions” section).
Use in children
Experience with the drug cardura have no children.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

Pfizer

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