Candide Valium vaginas. with an applicator 500mg 1 pc

Description

Composition
Active substance:
1 vaginal tablet contains: 500 mg of clotrimazole.
Excipients:
Lactose, starch, sodium carboxymethyl starch, talc purified, magnesium stearate, colloidal silicon dioxide, methyl parahydroxybenzoate (methyl paraben), propyl parahydroxybenzoate (propylparaben).
Description:
White, oblong, biconvex tablets with one end rounded and the chamfered edge of the other end. On one side of the tablet engraved «G».
Product form:
Vaginal tablets of 500 mg.
1 tablet a contour bezyacheykovuyu package (strip) of aluminum foil; 1 with the strip applicator, and instructions for use in a cardboard package.
Contraindications
Hypersensitivity to clotrimazole or adjuvants, I trimester of pregnancy.
Tablets should be avoided during menstruation.
Be wary – lactation.
Dosage
500 mg
Indications
Genital infections caused by yeast fungi of the genus Candida and / or Trichomonas vaginalis (vulvovaginal candidiasis, trichomoniasis);
genital superinfection caused by microorganisms sensitive to clotrimazole;
reorganization of the birth canal before delivery.
Interaction with other drugs
Vaginal administration of clotrimazole reduces Amphotericin B activity and other polyene antibiotics. While the use of nystatin activity of clotrimazole could decrease.
Overdose
Use of the drug in high doses does not cause any reactions and conditions, life-threatening.
In the event of an unintended drug application (orally), the following symptoms: anorexia, nausea, gastralgia, impaired liver function; rarely – drowsiness, hallucinations, pollakiuria, skin allergiichsekie reaction.
No specific antidote. INT should be administered activated charcoal. If necessary symptomatic treatment.
pharmachologic effect
Pharmacological group:
Antifungal agent.
Pharmacological properties:
Candide is an antifungal broad-spectrum topical. Antifungal effect of clotrimazole active principle (imidazole derivative) is connected with the violation of the synthesis of ergosterol, a component of fungal cell membranes that modifies membrane permeability and cause subsequent lysis of the cells. In low concentrations fungistatic effect, and large – fungicide, not only in proliferating cells. The fungicidal concentrations interacts with mitochondrial and peroxidase enzymes, resulting in increased concentrations of hydrogen peroxide up to a toxic level, which also contributes to the destruction of fungal cells.
It is effective against dermatophytes, yeast and molds, as well as the causative agent of multi-colored lichen (Pityriasis versicolor) and the pathogen erythrasma. It has antimicrobial action against Gram-positive (staphylococci, streptococci) and Gram-negative bacteria (Bacteroides, Gardnerella vaginalis), as well as against Trichomonas vaginalis.
Pharmacokinetics:
In the application of clotrimazole intravaginally absorption of 3-10% of the administered dose. High concentrations in the vaginal secretions, and low concentrations in the blood are retained within 48-72 hours. The liver is rapidly metabolized to inactive metabolites.
Pregnancy and breast-feeding
Clinical and experimental studies, it was found that the use of the drug during pregnancy or while breast-feeding has a negative impact on the health of the woman or the fetus (baby). However, the question of the advisability of the appointment of the drug should be decided individually after consulting a doctor.
Conditions of supply of pharmacies
Without recipe.
side effects
Itching, burning and swelling of the mucous membrane of the vagina, vaginal discharge, headache, gastralgia, frequent urination, intercurrent cystitis, burning sensation in the penis to sexual partners, pain during sexual intercourse.
special instructions
necessary simultaneous treatment of sexual partners for preventing urogenital reinfection. If trichomoniasis to more successful treatment together with Candide be applied other drugs having systemic effect (e.g., metronidazole orally). When simultaneous infection of the labia and the surrounding areas (candida vulvitis) should be further carried out by local treatment with Candide cream.
During pregnancy, vaginal tablets treatment should be carried out without an applicator. Patients with hepatic insufficiency should periodically monitor liver function. When signs of hypersensitivity or irritation of the treatment was stopped. If no effect within 4 weeks should confirm the diagnosis.
Storage conditions
At temperatures above 25 ° C, in a dry place, protected from light. In the reach of children.
Dosing and Administration
Locally. Only for intravaginal use.
Vaginal tablets of 500 mg is administered once in the evening in the vagina as deeply as possible in the supine position with slightly bent legs. Repeated treatment is possible after consulting a doctor.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist