Candid powder 30g 1% fl

Description

Composition
Active substance:
1 g of the preparation contains: 10.0 mg of clotrimazole.
Excipients:
Purified Talc 925.0 mg corn starch 50.0 mg colloidal silica 10.0 mg flavor 5.0 mg cosmetic.
Description:
The powder is white to light yellow in color with a characteristic odor.
Product form:
A powder for external use 10 mg / g.
30 g of powder in a plastic bottle closed with a polyethylene stopper, provided with holes with a paper label. The vial was covered with a plastic cap. 1 bottle with instructions for use placed in a cardboard box.
Contraindications
– Hypersensitivity to clotrimazole or any other components of the preparation – I of trimester.
Indications
– fungal infection of the skin – the interdigital fungal erosion – mycoses complicated by a secondary infection – multicolored lichen – erythrasma.
Interaction with other drugs
Clotrimazole reduces the activity of amphotericin B, and other polyene antibiotics. While the use of natamycin and nystatin may decrease the activity of clotrimazole.
Overdose
Overdosing is unlikely.
pharmachologic effect
Pharmacological group:
Antifungal agent.
Pharmacodynamics:
Antifungal broad-spectrum topical antimicrobial, protivoprotozoynoe, trihomonatsidnoe.
Antifungal effect of clotrimazole active principle (imidazole derivative) is connected with the violation of the synthesis of ergosterol, a component of fungal cell membranes that modifies membrane permeability and cause subsequent lysis of the cells. The fungicidal concentrations interacts with mitochondrial and peroxidase enzymes, resulting in increased concentrations of hydrogen peroxide up to a toxic level, which also contributes to the destruction of fungal cells. Exhibit fungicidal and fungistatic activity against dermatomitsetami (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), and yeast-like fungi (Candida spp, including Candida albicans;. Torulopsis glabrata, genus Rhodotorula, Pityrosporum orbiculare). Active against the causative agent of multi-colored lichen – Pityrosporum orbiculare (Malassezia furfur). It is effective against Gram-positive bacteria – pathogen erythrasma Corynebacterium minutissimum, and Staphylococcus spp, Streptococcus spp, Gram-negative bacteria -.. Bacteroides, Gardnerella vaginalis. In high concentrations active against Trichomonas vaginalis.
Pharmacokinetics:
Absorption
When applied topically clotrimazole is poorly absorbed through the skin. Bioavailability is less than 0.5%.
Distribution
Accumulates in the stratum corneum in a concentration higher than the minimum inhibitory concentration (MIC) for most of pathogenic fungi (50 – 100 mcg / ml). The concentration in the basal layer of the epidermis is 1.53 – 3 mg / ml.
It penetrates the nail keratin.
Metabolism and excretion
Biotransformed in the liver to inactive metabolites and excreted through the intestines.
Is output from the kidney (renal excretion fraction of 0.05% – 0.5%). The half of the starting material is 3.5 – 5 hours.
Pregnancy and breast-feeding
Clinical and experimental studies, it was found that the use of the drug during pregnancy or while breast-feeding has a negative impact on the health of the woman or the fetus (baby). However, the question of the advisability of the appointment of the drug in the II and III trimester should be decided individually after consultation with the doctor. In the appointment of the drug during the II and III trimester of pregnancy should take into account the ratio of the expected benefits from the appointment of the drug to the mother and the possible risk to the fetus. Application of the drug directly to the lactating mammary gland is contraindicated.
Conditions of supply of pharmacies
Available without prescription.
side effects
For topical application to the skin (rare): erythema, stinging, burning, irritation, itching, hives, edema. If any of these instructions side effects are compounded, or if you notice any other side effects not mentioned in the instructions, tell your doctor.
special instructions
– a preparation intended for external application; – Avoid contact with eyes; – use of the drug for children under 2 years of age only under medical supervision; – If swallowed seek medical advice.
The drug does not affect the ability to drive and engage in other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Effects on ability to drive a car / machinery
The drug does not affect the ability to drive and use machines.
Storage conditions
In a dry, dark place at a temperature of from 2 ° C to 25 ° C.
Keep out of the reach of children.
Dosing and Administration
Outwardly. It is applied to previously cleaned and dry skin twice a day (morning and evening). Candide powder can also be sprayed on clothes or shoes that are in direct contact with the affected areas. Candid powder may be used in combination with drugs Candid cream for external application of 1% or Candid solution for external application of 1%. Duration of therapy is individual and depends on the severity and localization of the disease. To achieve complete recovery should not terminate drug treatment immediately after the disappearance of symptoms of acute inflammation or subjective complaints. Duration of therapy should be, on average, about 3 – 4 weeks. For successful treatment it is important to regular use of the drug.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist