Candid external solution. 20ml 1% fl

Description

Composition
Active substance:
1 ml contains: 10.0 mg of clotrimazole.
Excipients:
Propylene glycol 990.0 mg.
Description:
Transparent, colorless, viscous liquid.
Product form:
A solution for external application of 1%.
20 ml of the product in plastic vials. 1 bottle with instructions for use placed in a cardboard box.
Contraindications
– Hypersensitivity to clotrimazole or other ingredients (propylene glycol, polyethylene glycol, isopropyl alcohol); – I trimester of pregnancy.
C care
Lactation.
Dosage
1 %
Indications
– fungal skin diseases, mycoses skinfold, the stop; – chromophytosis, erythrasma superficial candidiasis, caused by dermatophytes, yeasts (including Candida genus), molds and other fungi and pathogens sensitive to clotrimazole; – mycoses complicated by secondary pyoderma.
Interaction with other drugs
Amphotericin B, nystatin, natamycin reduce efficiency while applying clotrimazole. In the application of negative interactions with other drugs solution are not established and can not be expected, because clotrimazole resorptive capacity is very low.
Overdose
Use of a solution in high doses does not cause any reactions and conditions, life-threatening.
pharmachologic effect
Pharmacological group:
Antifungal agent.
Pharmacodynamics:
Antifungal broad-spectrum topical antimicrobial, protivoprotozoynoe, trihomonatsidnoe. Antifungal effect of clotrimazole active principle (imidazole derivative) is connected with the violation of the synthesis of ergosterol, a component of fungal cell membranes that modifies membrane permeability and cause subsequent lysis of the cells. In low concentrations fungistatic effect, and large – fungicide, not only in proliferating cells. The fungicidal concentrations interacts with mitochondrial and peroxidase enzymes, resulting in increased concentrations of hydrogen peroxide up to a toxic level, which also contributes to the destruction of fungal cells.
Exhibit fungicidal and fungistatic activity against dermatomitsetami (Trichophyton rubrum, Trychophyton mentagrophytes, Epidermophyton flocossum, Microsporum canis), and yeast-like fungi (Candida spp, including Candida albicans;. Torulopsis glabrate, genus Rhodotorula, Pityrosporum orbiculare). Vozbudtelya active against multi-colored lichen – Pityrosporum orbiculare (Malassezia furfur). It is effective against Gram-positive bacteria – pathogen erythrasma Corynebacterium minutissimum, and Staphylococcus spp, Streptococcus spp, Gram-negative bacteria -.. Bacteroides, Gardnerella vaginalis. In high concentrations active against Trichomonas vaginalis.
Pharmacokinetics:
Clotrimazole poorly absorbed through the skin and mucous membranes, and almost no systemic action. When applied topically clotrimazole concentration in the epidermis is greater than in the dermis and subcutaneous tissue.
Pregnancy and breast-feeding
Clinical and experimental studies, it was found that the use of the drug during pregnancy or while breast-feeding has a negative impact on the health of the woman or the fetus (baby). However, the question of the advisability of the appointment of the drug in the II and III trimester should be decided individually after consultation with vrachomvracha. In the appointment of the drug during the II and III trimester of pregnancy should take into account the ratio of the expected benefits from the appointment of the drug to the mother and the possible risk to the fetus.
Application of the drug directly to the lactating mammary gland is contraindicated.
Conditions of supply of pharmacies
Without a prescription.
side effects
Itching, burning, tingling in the field of application, erythema, blistering, swelling, irritation and skin peeling. Allergic reactions (pruritus, urticaria).
special instructions
Not recommended to apply the drug to the skin in the eye area.
When the appearance of signs of hypersensitivity or irritation of the treatment was stopped.
Patients with hepatic insufficiency should periodically monitor liver function.
If no effect within 4 weeks should confirm the diagnosis.
For external use only.
Effect on the ability to drive mechanisms and
The drug does not affect the ability to drive and use machines.
Storage conditions
In the dark place at a temperature of from 2 ° C to 25 ° C.
Keep out of the reach of children.
Dosing and Administration
Outwardly. The solution was applied to a thin layer 2 times a day on precleaned (with soap at a neutral pH) and dried affected skin.
The duration of treatment depends on the severity of the disease, the localization of pathological changes and the effectiveness of therapy. tinea treatment is carried out at least 4 weeks tinea versicolor – 1-3 weeks.
Fungal diseases of the skin of the feet is recommended to continue treatment for an additional at least 2 weeks after the elimination of symptoms.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist