Candid cream 1% 20g tube

Description

Composition
Active substance:
1 g of the preparation contains: 10.0 mg of clotrimazole.
Excipients:
Propylene glycol 50.0 mg, 120.0 mg white petrolatum, liquid paraffin 60.0 mg, wax emulsion tsetomakrogolny 135.0 mg, 10.0 mg benzyl alcohol, methyl parahydroxybenzoate 1.5 mg propyl parahydroxybenzoate 0.5 mg, butylhydroxytoluene 1 0 mg sodium dihydrogen phosphate dihydrate 0.8 mg sodium hydrogen phosphate 0.6 mg purified water up to 1000 mg.
Description:
Uniform cream white.
Product form:
Cream for external application of 1%.
20 g of product in an aluminum tube with a plastic screw lid provided with a protective tip for piercing the membrane. One tube together with instructions for use in a carton box.
Contraindications
– Hypersensitivity to clotrimazole or any other components of the preparation – I of trimester.
Carefully
Lactation.
Dosage
1 %
Indications
– fungal skin diseases, mycoses skinfold, the stop; – chromophytosis, erythrasma superficial candidiasis, caused by dermatophytes, yeasts (including Candida genus), molds and other fungi and pathogens sensitive to clotrimazole; – mycoses complicated by secondary pyoderma.
Interaction with other drugs
Amphotericin B, nystatin, natamycin reduce efficiency while applying clotrimazole.
When applying the cream negative interactions with other drugs is not known and can not be expected, because clotrimazole resorptive capacity is very low.
Overdose
Apply cream in high doses does not cause any reactions and conditions, life-threatening.
pharmachologic effect
Pharmacological group:
Antifungal agent.
Pharmacodynamics:
Protivobgribkovoe is a broad-spectrum topical antimicrobial, protivoprotozoynoe, trihomonatsidnoe.
Antifungal effect of clotrimazole active principle (imidazole derivative) is connected with the violation of the synthesis of ergosterol, a component of fungal cell membranes that modifies membrane permeability and cause subsequent lysis of the cells. The fungicidal concentrations interacts with mitochondrial and peroxidase enzymes, resulting in increased concentrations of hydrogen peroxide up to a toxic level, which also contributes to the destruction of fungal cells. Exhibit fungicidal and fungistatic activity against dermatomitsetami (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), and yeast-like fungi (Candida spp, including Candida albicans;. Torulopsis glabrata, genus Rhodotorula, Pityrosporum orbiculare). Active against the causative agent of multi-colored lichen – Pityrosporum orbiculare (Malassezia furfur). It is effective against Gram-positive bacteria – pathogen erythrasma Corynebacterium minutissimum, and Staphylococcus spp, Streptococcus spp, Gram-negative bacteria -.. Bacteroides, Gardnerella vaginalis. In high concentrations active against Trichomonas vaginalis.
Pharmacokinetics:
Clotrimazole poorly absorbed through the skin and mucous membranes, and almost no systemic action. The concentration in the deep layers of the epidermis is higher than the minimum inhibitory concentration for dermatophytes.
When applied topically clotrimazole concentration in the epidermis is greater than in the dermis and subcutaneous tissue.
Pregnancy and breast-feeding
Clinical and experimental studies, it was found that the use of the drug during pregnancy or while breast-feeding has a negative impact on the health of the woman or the fetus (baby). However, the question of the advisability of the appointment of the drug in the II and III trimester should be decided individually after consultation with the doctor. In the appointment of the drug during the II and III trimester of pregnancy should take into account the ratio of the expected benefits from the appointment of the drug to the mother and the possible risk to the fetus. Application of the drug directly to the lactating mammary gland is contraindicated.
Conditions of supply of pharmacies
Without a prescription.
side effects
Allergic reactions such as pruritus, urticaria, burning, tingling in the field application of the cream. Perhaps the appearance of erythema, blisters, swelling, skin irritation and flaking.
special instructions
Not recommended to apply the drug to the skin in the eye area.
Patients with hepatic insufficiency should periodically monitor liver function.
When the appearance of signs of hypersensitivity or irritation of the treatment was stopped.
If no effect within 4 weeks should confirm the diagnosis.
Effect on the ability to drive mechanisms and
The drug does not affect the ability to drive and use machines.
Storage conditions
In a dry, dark place at a temperature of from 2 ° C to 25 ° C.
Keep out of the reach of children.
Dosing and Administration
Outwardly. The cream is applied a thin layer of 2-3 times a day on precleaned (with soap at a neutral pH) and dried affected skin and gently rubbed.
The duration of treatment depends on the severity of the disease, the localization of pathological changes and the effectiveness of therapy. tinea treatment is carried out at least 4 weeks tinea versicolor – 1-3 weeks.
Fungal diseases of the skin of the feet is recommended to continue treatment for an additional at least 2 weeks after the elimination of symptoms.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist