Buscopan suppositories 10mg 10 pc

Description

Composition
Active substance:
1 suppository contains hyoscine butylbromide 10 mg.
Excipients:
Purified Water – 10 mg, hard fat W45-1610 mg.
Description:
White or ivory, smooth, oblong-shaped suppositories.
Product form:
Rectal suppositories of 10 mg.
5 suppositories in a strip of aluminum foil. By 2 strips in a cardboard box with instructions for use.
Contraindications
Myasthenia gravis, megacolon.
Hypersensitivity to hyoscine butylbromide or any other component of the formulation. Children up to 6 years.
Pregnancy, lactation.
Carefully.
It should be used with caution in preparation in the following clinical situations: suspected ileus (including pyloric stenosis): obstruction of the urinary tract (including prostate hyperplasia), tachyarrhythmias (including atrial tachyarrhythmia) zakratougolnaya glaucoma.
Dosage
10 mg
Indications
Renal colic, biliary colic, spastic dyskinesia of the biliary tract and gallbladder, cholecystitis, intestinal colic, pilorospazm, gastric ulcer and duodenal ulcer in the acute phase (in the complex therapy), tuberculosis.
Interaction with other drugs
Buscopan may enhance anticholinergic effects of tricyclic and tetracyclic antidepressants, antihistamines, antipsychotics, quinidine and disopyramide Amantadine and anticholinergic drugs (eg tiotropium bromide, ipratropium bromide, atropine compounds). The simultaneous use of Buscopan and dopamine antagonists, such as metoclopramide, leads to a weakening effect of both drugs on the gastrointestinal tract.
Buscopan may exacerbate tachycardia caused by beta-adrenergic agents.
Overdose
So far, cases of overdose buskopanom not described, therefore the following symptoms and recommendations are theoretical.
Symptoms.
Possible anticholinergic symptoms: urinary retention, dry mouth, flushing, tachycardia, inhibition of motility of the gastrointestinal tract, as well as transient visual disturbances.
Treatment.
Overdose symptoms buskopanom cropped holinomimetikami. Patients with glaucoma pilocarpine administered as eye drops. If necessary, cholinomimetics are administered systemically, e.g., neostigmine 0.5- 2.5 mg intramuscularly or intravenously. Cardiovascular complications are treated according to the usual therapeutic rules. Paralysis of respiratory muscles show intubation, mechanical ventilation. In case of delay cannulated urine bladder. Is supportive therapy.
pharmachologic effect
Pharmacological group:
M-holinoblokator.
Pharmacodynamics:
Provides local antispasmodic effect on the smooth muscles of internal organs (gastrointestinal tract, biliary tract, urinary tract), reduces the secretion of digestive glands. Local skin effects explained ganglioblokiruyuschimi and antimuscarinic activity of the drug. As the quaternary ammonium derivative, hyoscine butyl bromide does not penetrate the blood-brain barrier, however anticholinergic effect on the central nervous system is offline.
Pharmacokinetics:
As the quaternary ammonium derivative thereof, and having a high polarity, hyoscine butylbromide slightly absorbed in the gastrointestinal tract. After rectal drug absorption is 3%. Mean absolute bioavailability is less than 1%. Hyoscine butylbromide due to high affinity for muscarinic and nicotinic receptors is distributed mainly in the muscle cells of the abdominal cavity and the pelvic and in intramural ganglia of the abdominal cavity. Communication with plasma proteins (albumin) – low at about 4.4% was found that the drug (at a concentration of 1 mmole) in vitro reacted with choline transport (1.4 nmol) in the epithelial cells of the human placenta.
After rectal administration renal elimination of the drug is 0.7-1.6%; elimination occurs primarily through the intestine. Renal excretion of metabolites hyoscine butylbromide is less than 0.1% of the dose. Metabolites excreted in the urine, weakly associated with muscarinic receptors, so they are not active and do not possess pharmacological properties.
Pregnancy and breast-feeding
Data on the use of the drug during pregnancy and the penetration of the drug and its metabolites in breast milk is limited.
Studies on the effect of the drug on fertility have been conducted.
Conditions of supply of pharmacies
Without recipe.
side effects
Many of these unwanted effects may be related to the anticholinergic properties of the drug. Anticholinergic side effects are usually mild and disappear on their own.
Immune system:
Anaphylactic shock, anaphylactic reactions, shortness of breath, skin reactions (e.g., hives, rash, erythema, pruritus) and other forms of hypersensitivity.
Cardio-vascular system:
Tachycardia.
From the digestive system:
Dry mouth.
Skin and subcutaneous tissue disorders:
Disgidroticheskaya eczema.
From the urinary system:
Urinary retention.
special instructions
In cases where the abdominal pain of unknown origin continues or gets worse, or if at the same time marked symptoms such as fever, nausea, vomiting, change in consistency of stool and frequency of bowel movements, pain abdomen, lower blood pressure, fainting or blood in the stool, you should immediately seek medical advice.
Effects on ability to road management and utilization mechanisms.
Studies on the effect of the drug on the ability to drive vehicles and management mechanisms are not carried out.
Storage conditions
Stored in a dry place at a temperature not higher than 25 ° C.
Keep out of the reach of children!.
Dosing and Administration
Rectally.
If your doctor is not indicated differently, the recommended dosing regimen:
Adults and children over 6 years: 1-2 rectal suppository 3-5 times a day.
Suppositories should be removed from the packaging and put the pointed end into the rectum.
The drug should not be used on a daily basis for more than 3 days without consulting a doctor.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist