Bronhobos caps. 375mg 30 pieces

Description

Composition
Active substance:
1 capsule contains: karbotsistein 375.0 mg.
Excipients:
Corn Starch – 23.00 mg magnesium stearate – 2.00 mg, gelatin – 8.00 mg colloidal silicon dioxide – 2.00 mg.
Description:
Hard gelatin capsules are opaque yellow №0, filled with white powder.
Product form:
Capsules 375 mg. 10 capsules in blister PVC / Al. 3 blisters with instructions for use in a cardboard box.
Contraindications
Hypersensitivity to carbocisteine ​​or other ingredients, gastric ulcer and duodenal ulcer in acute, chronic glomerulonephritis (exacerbation), cystitis, children up to 15 years, pregnancy (I term).
Precautions: while taking the drug in chronic glomerulonephritis (in history), gastric ulcer and duodenal ulcer (in history), pregnancy (II-III trimesters) and during breastfeeding.
Dosage
375 mg
Indications
Acute and chronic bronchopulmonary diseases accompanied by the formation of viscous sputum (tracheitis, bronchitis, tracheobronchitis, bronchial asthma, bronchiectasis) and mucus (inflammation of the middle ear diseases of the nose and paranasal sinuses – rhinitis, otitis media, sinusitis), preparation for bronchoscopy and / or bronhografii.
Interaction with other drugs
Karbotsistein glucocorticosteroid increases efficiency and antibacterial therapy of inflammatory diseases of the upper and lower respiratory tract, potentiates the bronchodilator effect of theophylline. antitussive activity carbocisteine ​​weaken and atropine means.
Overdose
Symptoms: gastralgia, nausea, diarrhea.
Treatment: symptomatic.
pharmachologic effect
Pharmacological group:
Expectorant mucolytic agent.
Pharmacodynamics:
Mucolytic and expectorant action is caused by activation of sialic transferase – enzyme goblet cells of the bronchial mucosa. Normalizes the proportion of acidic and neutral sialomutsinov bronchial secretions. Reduces the viscosity of bronchial secretions and detachable from the paranasal sinuses, facilitating expectoration of mucus and reduces cough. Promotes regeneration of the mucosa, normalizes its structure, activates the activity of the ciliary epithelium. Restores immunoglobulin IgA secretion (specific protection) and the number of sulfhydryl groups mucus components (non-specific protection), improves mucociliary clearance.
Pharmacokinetics:
Karbotsistein rapidly absorbed after oral administration. Bioavailability – low (less than 10% of the dose). The maximum concentration in serum and respiratory mucosa is achieved 2-3 hours after dosing into and retained in the mucosa during 8 hours. It is metabolized in the liver (which has the effect of “first pass” through the liver). Excreted mainly by the kidneys partially intact, partially in the form of metabolites. The half-life of about 2 hours.
Pregnancy and breast-feeding
In II and III trimester of pregnancy, the drug is prescribed only when the intended benefits to the mother outweighs the potential risk to the fetus. If necessary, the appointment during lactation should decide the issue of termination of breastfeeding.
Conditions of supply of pharmacies
Without recipe.
side effects
On the part of the gastrointestinal tract: sometimes marked nausea, vomiting, diarrhea, epigastric pain, gastrointestinal bleeding.
Allergic reactions: itching, hives, rash, angioedema.
Other: dizziness, weakness, malaise.
special instructions
In patients with gastric ulcer and duodenal ulcer in the history of the dose should be reduced. Treatment can be combined with physiotherapy. Effect of the drug on the ability to drive and work requiring high concentration and psychomotor speed reactions, has not been studied.
Storage conditions
At a temperature of 15 to 30 C.
Keep out of the reach of children.
Dosing and Administration
For ingestion. Adults and adolescents over 15 years: 750 mg (2 capsules) three times a day. After achieving a therapeutic effect daily dose reduced to 1.5 g: 750 mg (2 capsules) twice a day. Treatment should not last more than 8-10 days without consulting a doctor.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist