Bromhexinum tab 8mg 50 pcs Medisorb

Description

Composition
Active substance:
1 tablet contains: bromhexine hydrochloride 8 mg ;.
Excipients:
Lactose (milk sugar), potato starch, sucrose (sugar), calcium stearate.
Description:
Tablets white ploskotsilindricheskoy form chamfered.
Product form:
The tablets 8 mg.
10 tablets in blisters.
20, 50 or 100 tablets per polymer jar.
Each bank or 1, 2, 5, 10 contour cell packages together with instructions for use placed into the package.
Placing permitted outline package together with an equal number of instructions for use in multipacks.
Contraindications
Increased sensitivity to the drug; peptic ulcer in the acute stage; pregnancy (I term); lactation; Children up to age 6 years.
Precautions: kidney and / or liver insufficiency; bronchial diseases accompanied by excessive accumulation of secretions; history – gastric bleeding. .
Dosage
8 mg
Indications
Bromhexine is used: – treatment of bronchopulmonary diseases accompanied by formation of high viscosity sputum (bronchial asthma, cystic fibrosis, tuberculosis, pneumonia, tracheobronchitis, obstructive bronchitis, bronchiectasis, emphysema, pneumoconiosis); – rehabilitation of the bronchial tree in the preoperative period and during therapeutic and diagnostic intrabronchial manipulation; – prevention of accumulation in the bronchi thick viscous sputum after surgery.
Interaction with other drugs
Bromhexine not administered simultaneously with drugs containing codeine, since it complicates the liquefied sputum expectoration.
Bromhexine facilitates the penetration of antibiotics (amoxicillin, erythromycin, cephalexin, oxytetracycline), sulfa drugs in the bronchial secretion in the first 4-5 days of antimicrobial therapy.
Incompatible with alkaline solutions.
Overdose
Symptoms: diarrheal disorders, including nausea, vomiting, diarrhea.
Treatment: artificial vomiting, gastric lavage (the first 1-2 hours after administration).
pharmachologic effect
Pharmacodynamics:
The drug has mucolytic (secretolytic) and expectorant action. Mucolytic effect is associated with depolymerization and the watering down mukoproteinovyh and mucopolysaccharide fibers. Bromhexine has a weak antitussive effect.
It reduces the viscosity of sputum increases serous components bronchial secretion, activates the ciliated epithelium and increases the volume and improves expectoration. Stimulates the production of endogenous surfactant provides stability of alveolar cells in the breathing process. The effect appears after 2-5 days of starting treatment.
Pharmacokinetics:
The ingestion bromhexine almost completely (99%) absorbed during 30 minutes. Bioavailability is 80% due to “first pass effect” through the liver. The bromhexine plasma is associated with proteins, penetrates the blood-brain and placental barriers. In the liver, bromhexine undergoes demethylation and oxidation. The half-life of 15 hours due to slow reverse diffusion from the tissues. Excreted by the kidneys. In chronic renal failure isolation is disturbed bromhexine metabolite. Repeated application of bromhexine may accumulate.
Conditions of supply of pharmacies
Without recipe.
side effects
Rarely, chronic administration of the drug.
For the skin: allergic reactions (skin rash).
On the part of the digestive tract: nausea, vomiting, dyspepsia, exacerbation of gastric ulcers and 12 duodenal ulcer, increase in liver enzymes in the blood serum.
The respiratory system: allergic reactions (rhinitis).
In these cases, the drug should be discontinued.
Storage conditions
In a dry, dark place at a temperature not higher than 25 C.
Keep out of the reach of children.
Dosing and Administration
Bromhexine taken orally without food. Adults and children over 14 years appoint 1 – 2 tablets (8-16 mg) 3-4 times a day; children 6 to 14 years of 1 tablet (8 mg) 3 times a day. The course of treatment – from 4 to 28 days.
In the course of treatment is recommended to drink plenty of fluids that supports sekretoliticheskoe action bromhexine.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist