Bromhexinum tab 4mg for children 50 pcs ozone

Description

Composition
Active substance:
bromhexine hydrochloride – 4.00 mg.
Excipients:
monohydrate lactose (milk sugar) – 80.23 mg; corn starch – 11.54 mg; Povidone K-25 – 3.46 mg; magnesium stearate – 0.77 mg.
Description:
round pills Valium white or nearly white with a facet and Valium.
Product form:
Tablets for children of 4 mg.
10 tablets in blisters of PVC film and aluminum foil printed patent.
Or
50 tablets in banks of polyethylene or polypropylene for medicines, caps of the capped high-pressure polyethylene having a first opening control or polypropylene lids with a system “push-turn” or caps of high density polyethylene with a first control opening.
5 one bank or contour of cellular packaging together with instructions for use placed in a cardboard box (pack).
Contraindications
Hypersensitivity to the drug, peptic ulcer and 12
duodenal ulcer, pregnancy, breastfeeding, children under 3 years old, hereditary lactose intolerance, glucose-galactose malabsorption, lactase deficiency.
With caution in patients with a history of gastric bleeding, diseases of the bronchi accompanied by excessive accumulation of secretions, with a history of episodes of hemoptysis, kidney and / or liver failure.
Dosage
4 mg
Indications
Acute and chronic bronchopulmonary diseases accompanied by difficulty in discharge of viscous sputum: tracheobronchitis, bronchitis of various etiologies (including complicated bronchiectasis), bronchial asthma, pulmonary tuberculosis, pulmonary emphysema, pneumonia (acute and chronic), pneumoconiosis, cystic fibrosis.
Remediation of the bronchial tree in the preoperative period and during therapeutic and diagnostic intrabronchial manipulation congestion prevention in a thick viscous bronchial sputum after surgery.
Interaction with other drugs
Bromhexine not administered simultaneously with drugs that suppress the cough center (including containing codeine) because it complicates discharge of liquefied sputum (bronchial secretion accumulation in the airways).
Bromhexine promotes penetration of antibiotic (amoxicillin, ampicillin, erythromycin, cephalexin, oxytetracycline), sulfa drugs in bronchial secretion in the first 4-5 days antimicrobial therapy. The combined use of bromhexine with some non-steroidal anti-inflammatory drugs (salicylates, phenylbutazone or butadionom) may irritate the stomach lining.
Overdose
Possible symptoms: nausea, vomiting, diarrhea and other gastrointestinal disorders.
Treatment: No specific antidote. In overdose must cause vomiting, then give the patient a liquid (water or milk). Gastric lavage recommended for 1-2 hours after ingestion.
pharmachologic effect
Pharmacological group:
expectorant mucolytic agent.
Pharmacodynamics:
Mucolytic (secretolytic) means has a weak antitussive expectorant effect. Reduces the sputum viscosity (depolymerizes mukoproteinovyh and mucopolysaccharide fibers increases serous components bronchial secretions); activates the ciliated epithelium and increases the volume and improves expectoration. Stimulates the production of endogenous surfactant provides stability of alveolar cells in the breathing process. The effect appears after 2-5 days of starting treatment.
Pharmacokinetics:
The ingestion bromhexine almost completely (99%) is absorbed into the gastrointestinal tract within 30 minutes. Bioavailability – low (primary effect “pass” through the liver). Bromhexine plasma is bound to proteins, it penetrates the blood-brain and placental barriers, as well as breast milk. In the liver, bromhexine undergoes demethylation and oxidation, it is metabolised to a pharmacologically active ambroxol. The half-life (T1 / 2) – 15 hours (due to the slow reverse diffusion from the tissues). Excreted by the kidneys. In chronic renal failure disturbed bromhexine metabolite excretion. Repeated application of bromhexine may accumulate.
Pregnancy and breast-feeding
Bromhexinum crosses the placental barrier and into breast milk. The drug is contraindicated during pregnancy and lactation. If necessary, use during lactation at the time of treatment should stop breastfeeding.
Conditions of supply of pharmacies
Without a prescription.
side effects
On the part of the gastrointestinal tract: abdominal pain, dyspepsia, including nausea, vomiting, aggravation of gastric ulcer and 12 duodenal ulcer.
Allergic Reactions: Hypersensitivity reactions (skin rash, pruritus, angioedema, rhinitis), urticaria, fever, anaphylactic reactions, including anaphylactic shock.
Skin and subcutaneous tissue disorders: Stevens-Johnson syndrome, Lyell syndrome, acute generalized exanthematous pustulosis.
Other: dizziness, headache, increased activity of “liver” transaminases in blood serum.
special instructions
Very rarely reported occurrence of Stevens-Johnson syndrome and toxic epidermal necrolysis, which are in temporal association with the intake of the drug Bromhexine. When changes occur in the skin or mucous membrane should stop taking the drug and consult a doctor.
In the course of treatment is recommended to drink plenty of fluids that supports sekretoliticheskoe action bromhexine.
In children, treatment should be combined with postural drenanazhem and vibration massage of the chest, facilitating the evacuation of secretions from the bronchial tubes.
Impact on the ability to drive vehicles and operate machinery
Receiving recommended therapeutic doses (16 mg 3 times daily) did not affect the rate of patient psychomotor reactions. In the case of side effects when using the drug, caution should be exercised in the management of vehicles and mechanisms.
Storage conditions
In the dark place at a temperature not higher than 25 ° C.
Keep out of the reach of children
Dosing and Administration
Inside, regardless of the meal.
Children older than 10 years of age: 24-48 mg (6-12 tab.) Divided into 3 doses per day (daily dose –
24-48 mg of bromhexine).
Children 6 to 10 years and in patients weighing less than 50 kg – 12-24 mg of (3-6 tab.)
divided into 3 doses per day (daily dose – 12-24 mg of bromhexine).
Children from 3 to 6 years of age – 12.6 mg (1 -3 1/2 tab.), Divided into 3 doses per day (daily dose –
6-12 mg of bromhexine).
The therapeutic effect may occur 4 – 6 days of treatment.
The course of treatment from 4 to 28 days.
Patients with renal insufficiency prescribe smaller doses or increase the interval between doses.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist