Bromhexinum syrup without alcohol 4mg / 5ml 100ml vials Pharmstandard apricot flavor

Description

Composition
Active substance:
5 ml syrup contains: bromhexine hydrochloride – 4.0 mg.
Excipients:
Propylene glycol – 1250.0 mg of sorbitol (sorbitol) – 2000.0 mg, succinic acid – 12.5 mg, eucalyptus leaf oil (eucalyptus oil) – 0.75 mg Sodium benzoate – 2.5 mg Apricot flavor or cherry flavoring or pear flavor – 5.0 mg water (purified water) – up to 5 ml.
Description:
Colorless or slightly yellow liquid with a fruity odor.
Product form:
Syrup [apricot, cherry, pear], 4 mg / 5 ml.
100 ml of syrup in dark glass bottles. One vial with instructions for use and dimensional measuring spoon or syringe are placed in a pile of cardboard.
Contraindications
Increased sensitivity to the drug; Hereditary fructose intolerance (due to the presence of the drug sorbitol); peptic ulcer (in the acute phase); pregnancy (I term); lactation.
Precautions – bronchial diseases accompanied by excessive accumulation of secretions; – renal and / or liver insufficiency; – a history of stomach bleeding.
Dosage
0.8 mg / ml
Indications
Respiratory diseases, accompanied by the formation of viscous mucus trudnootdelyaemoy: tracheobronchitis, bronchitis (different etiology, including bronchitis, bronchiectasis complicated), pneumonia (acute and chronic), cystic fibrosis, asthma, pulmonary tuberculosis.
Remediation bronchial tree preoperative, postoperative period (prevention of accumulation of viscous mucus), as well as during intrabronchial manipulation (diagnostic or therapeutic).
Interaction with other drugs
Bromhexine can be administered concomitantly with other drugs used in the treatment of bronchopulmonary diseases.
Bromhexinum not administered with drugs that suppress the cough center (including those containing codeine), as this makes it difficult expectoration attenuated sputum.
Bromhexine facilitates the penetration of antibiotics (amoxicillin, erythromycin, cephalexin, oxytetracycline) and sulfa drugs in the bronchial secretion in the first 4-5 days of antimicrobial therapy.
Bromhexine is not compatible with alkaline solutions.
Overdose
Symptoms: diarrheal disorders, including nausea, vomiting, diarrhea.
Treatment: artificial vomiting, gastric lavage (the first 1 to 2 hours after administration).
pharmachologic effect
Pharmacological group:
Expectorant mucolytic agent.
Pharmacodynamics:
The drug has mucolytic (sekretoliticheskoe), expectorant and weak antitussive effect. Mucolytic effect associated with depolymerization and liquefaction mukoproteinovyh and mucopolysaccharide fibers and also with increasing amounts of serous component bronchial secretions. Bromhexine increases the activity of the ciliated epithelium, improves expectoration. Stimulates the production of endogenous surfactant provides stability of alveolar cells in the breathing process. The clinical effect is seen after 2-5 days from the start of treatment.
Pharmacokinetics:
The ingestion bromhexine almost completely (99%) absorbed during 30 minutes. Bioavailability is 80% (the “first pass” through the liver). In plasma, bromhexine binds to proteins, penetrates the blood-brain and the placental barrier.
It is metabolized in the liver by demethylation and oxidation, with the formation of a pharmacologically active metabolite, ambroxol.
The half-life (T1 2) of 15 hours due to slow reverse diffusion from the tissues. Excreted by the kidneys. In chronic renal failure isolation is disturbed bromhexine metabolite. Repeated application of drug accumulation is possible.
Conditions of supply of pharmacies
Without recipe.
side effects
Allergic reactions, dyspeptic symptoms (nausea, vomiting), dizziness, headache, exacerbation of gastric ulcer and duodenal ulcer, increased activity of “liver” transaminases.
Flatulence, diarrhea, weakness, hyperglycemia (decompensated patients with diabetes mellitus) – due to the presence of sorbitol drug.
special instructions
During the treatment it is recommended to use a sufficient amount of fluid, which increases sekretoliticheskoe expectorant action and bromhexine.
In children, treatment should be combined with postural drainage and vibration massage of the chest, facilitating the evacuation of secretions from the bronchial tubes.
In the absence of effect within 4-5 days, consult your doctor.
In 5 ml of syrup contains 2 g of sorbitol, which corresponds to 0.17 bread units.
Effects on ability to drive vehicles, mechanisms:
The drug does not affect the ability to drive vehicles and a variety of mechanisms, as well as other classes of potentially hazardous activities that require attention and speed of mental and motor responses.
Storage conditions
Store at a temperature not higher than 25 C.
Keep out of the reach of children.
Dosing and Administration
Bromhexine taken orally without food.
Adults and children over 14 years prescribed 8-16 mg (10-20 ml) 3-4 times a day.
Children under 2 years old, 2 mg (2.5 ml) 3 times a day, from 2 to 6 years, 4 mg (5 ml) 3 times a day, 6 to 14 m l e – 8 mg (10 ml) 3 times a day.
For accurate dosing of the drug, depending on the proposed configuration using a measuring spoon or graduated syringe enclosed in packaging.
In the case of measuring syringe: 1. Open the cap of the vial. 2. Insert the syringe into the hole mer adapter installed in the neck of the vial. 3. Turn the bottle upside down and gently pull the piston down, picking up a measuring syringe syrup to the desired mark. 4. Return the bottle to its original position and remove the measuring syringe, gently turning it. 5. Let your child medication inside by measuring syringe. To ensure a smooth syrup additions to the oral cavity slowly press the piston.
After each use, the syringe dimensional rinse in running water and dry disassembled at room temperature out of reach of children.
Keep the measuring syringe should be in the package, along with the drug.
Patients with renal failure administered smaller doses or increase the interval between administration of the drug.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist