Bicillin 3 powder prig.susp.v / m 200 + 200 + fl 200tys.ed

Description

Composition
Active substance:
1 vial contains 600 000 IU: benzathine penicillin G 200,000 U, sodium penicillin G (benzylpenicillin sodium salt) or potassium benzylpenicillin (penicillin G potassium) 200 000 IU, benzylpenicillin procaine (novocaine benzylpenicillin salt) 200 000 IU
1 vial 1 200 000 U comprises benzathine penicillin G 400,000 U, sodium penicillin G (benzylpenicillin sodium salt) or potassium benzylpenicillin (penicillin G potassium) 400 000 IU, benzylpenicillin procaine (novocaine benzylpenicillin salt) 400 000 IU.
Product form:
Powder for suspension for intramuscular 600000 U, 1200000 U.
By 600,000 and 1,200,000 units IU in 10 ml capacity vials. 1, 5 or 10 vials together with instructions for use in paper cartons.
Contraindications
Hypersensitivity to the drug penicillin, and others. Beta-lactam antibiotics, for procaine.
Precautions: pregnancy, lactation, renal failure, for allergic diseases, including bronchial asthma, hay fever (including history), pseudomembranous colitis.
Dosage
+200 200 200 thousand units
Indications
Infection (in adults), caused by susceptible microorganisms: syphilis and other diseases caused by Treponema pallidum (yaws), streptococcal infections (excluding infections by group B streptococcus) – acute tonsillitis, scarlet fever, wound infections, erysipelas. Rheumatism (prevention).
pharmachologic effect
Pharmacological group:
The antibiotic penicillin biosynthetic.
Pharmacodynamics:
Combined germicide salts of benzylpenicillin 3: dibenzyl etlendiaminovoy, procaine, sodium or potassium having prolonged action. It inhibits the synthesis of the cell wall of microorganisms.
It is active against gram-positive pathogens: Staphylococcus spp. (Neobrazuyuschih penicillinase)
Streptococcus spp., Including Streptococcus pneumoniae,
Corynebacterium diphtheriae, anaerobic spore-forming rod: Clostridium spp, Bacillus anthracis, Actinomyces israelii;. Gram-negative organisms: Neisseria gonorrhoeae, Neisseria meningitidis, Treponema spp.
By the action of the drug-resistant strains of Staphylococcus spp., Forming penicillinase.
Pharmacokinetics:
After intramuscular administration absorbed slowly release from the depot benzylpenicillin. When administered once stored in high therapeutic concentrations 6-7 days. The time required to reach maximum concentration (TCmax) in plasma – 12–24 hours after injection. On day 14 after administration of 2.4 million U concentration in serum is 0.12 ug / ml; on day 21 after administration of 1.2 million units – 0.06 ug / ml (1 unit = 0.6 micrograms). Penetration into liquid high in the tissue – is low. Relationship to plasma proteins – 40-60%. Crosses the placental barrier, it is found in mother’s milk. Slightly metabolized, excreted mainly by the kidneys in unchanged form.
Pregnancy and breast-feeding
Application of pregnancy is possible only when the intended benefits to the mother outweighs the potential risk to the fetus. If necessary, use during lactation should decide the issue of termination of breastfeeding.
Conditions of supply of pharmacies
On prescription.
Storage conditions
In a dry place at a temperature of from 8 to 15 C. Keep out of reach of children.
Dosing and Administration
Administered by deep intramuscular injection into the upper outer quadrant of the gluteal muscles in a dose of 300 thousand.
ED. If necessary, they do 2 injections at different buttocks. Repeated injections produced 4 days after the last injection.
At a dose of 600 thousand.
U 1 is administered every 6 days.
In the treatment of primary and secondary syphilis single dose of 1.8 million units. The treatment course consists of 7 injections. The first injection is carried out at a dose of 300 thousand.
ED, a second injection – after 1 day in full single dose is performed subsequent injections 2 times per week in a single full dose.
In the treatment of secondary and recurrent early latent syphilis is used for the first injection dose 300 thousand.
U, for subsequent injections – 1.8 million units. Injection is carried out 2 times a week. The course of treatment – 14 injections.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist