Bellastezin 10 pcs Table

Description

Composition
Active substance:
1 tablet contains: benzocaine (benzocaine) – 300 mg, belladonna leaf extract (thick belladonna extract) – 15 mg.
Excipients:
Potato starch, sodium carboxymethyl starch (Primogel), colloidal silica (Aerosil), talc, calcium stearate.
Description:
Round Valium tablets from light yellow to light brown in color with a splash, with a facet and Valium.
Product form:
Tablets.
10 tablets in blisters. 1, 2 blisters together with instructions for use placed in a pile of cardboard.
Contraindications
Increased sensitivity to the drug, angle-closure glaucoma, prostatic hyperplasia, pregnancy, lactation, infancy to 6 years.
Carefully.
Patients with polyneuropathy, hyperthyroidism, coronary heart disease, congestive heart failure, hypertension, kidney disease, diaphragmatic hernia, reflux esophagitis.
Indications
Is used as a symptomatic treatment for diseases of the gastrointestinal tract, accompanied by increased secretion of the stomach and spasms of smooth muscles for the purpose of relief of pain (hyperacid gastritis, peptic ulcer and 12 duodenal ulcer).
Interaction with other drugs
When applying Bellastezina: -c amantadine, antiarrhythmic anticholinergics (including quinidine), tricyclic antidepressants, nefopam, glutetimid – intensified anticholinergic effects of the drug; c opioid analgesics and drugs depressing the central nervous system – possible CNS depression; c butyrophenones (haloperidol) and organic nitrates – increased intraocular pressure; c corticosteroids for systemic use – is reduced and the effect of corticosteroids may increase intraocular pressure; pilocarpine -c – decreases its effect in the treatment of glaucoma; c M-holinoblokatorami – intensified anticholinergic effects; c furosemide – possible orthostatic hypotension; c reserpine, inhibitors of monoamine oxidase (MAO), guanethidine, antacids, ascorbic acid, attapulgitom – effect of the preparation is reduced; c levodopa – reduced systemic concentrations of levodopa, so it is necessary to adjust the dosage; -with some antihistamines (including meclizine) – enhanced anti-histamine effect; c beta-adrenoceptor blockers – reduces their effect; -c hormonal contraceptives – contraceptive effect is reduced; -with no selective inhibitors of reverse neuronal uptake of monoamines – amplified sedative effects; c nonsteroidal anti-inflammatory drugs, griseofulvin, digitoxin, doxycycline, metoclopramide, metronidazole – reduces the effect of these drugs; c ketoconazole – increasing gastric pH Bellastezinom reduces absorption of ketoconazole, however Bellastezin should be no earlier than 2 hours after the administration of ketoconazole; c sulfonamides – reduces their antibacterial activity; c indapamide, nizatidine – increases their effect; -c preparations containing potassium – may damage the mucosa of the gastrointestinal tract.
Overdose
Symptoms: increasing incidence of adverse reactions, nausea, vomiting, tachycardia, decrease in blood pressure, agitation, irritability, tremors, convulsions, insomnia, drowsiness, hallucination, hyperthermia, tachypnea and hyperpnoea possible signs of dehydration, CNS depression, inhibition of the activity of the respiratory and vasomotor centers .
Treatment: gastric lavage, administration of activated charcoal, correction fluid and electrolyte balance, the parenteral administration of cholinomimetics and anticholinesterases. Treatment is symptomatic.
pharmachologic effect
Pharmacological group:
Preparations for the treatment of functional disorders of the gastrointestinal tract. Antispasmodics and holinoblokatory in combination with other drugs. Antispasmodics in combination with other drugs.
Pharmacodynamics:
Combined preparation has antispasmodic, local anesthetic and analgesic effect.
Spasmolytic effect due to the effect of belladonna alkaloids: owing m-anticholinergic effect decreases the tonus of smooth muscle organs (bronchial tree, the abdominal organs, etc.) is eliminated intestinal muscle spasm, biliary tract, reduced motility, secretion of digestive, salivary glands and other develops dromotropic and positive chronotropic effect. Benzocaine has a local anesthetic action.
Pharmacokinetics:
Pharmacokinetics of belladonna. Well absorbed from the gastrointestinal tract (GIT). It is not known whether belladonna alkaloids into breast milk. Atropine, hyoscyamine, scopolamine cross the placenta. Atropine and hyoscyamine readily penetrate the blood-brain barrier. Belladonna alkaloids hydrolyzed to tropine and tropine acid. The kidneys and, to a lesser extent through the intestines.
Pharmacokinetics benzocaine. Benzocaine is poorly soluble in water, which leads to its slow absorption. Like all ester derivatives of para-aminobenzoic acid, splits esterase in the blood plasma and liver. As a result, formed of p-aminobenzoic acid and ethyl alcohol, is metabolized to atsetilkoenzima A. Para-aminobenzoic acid undergoes conjugation with glycine or excreted by the kidneys unchanged.
Pregnancy and breast-feeding
Use during pregnancy is contraindicated.
Use of the drug is contraindicated in the I trimester of pregnancy due to the teratogenic effects of belladonna alkaloids, in the II and III trimester – is not recommended due to the lack of use of safety data in this group of patients.
the penetration of data belladonna alkaloids into breast milk is not available, therefore the use of the drug is not recommended during breast-feeding.
Conditions of supply of pharmacies
Without recipe.
side effects
From the nervous system: headache, dizziness, nervousness, somnolence, agitation (especially in older patients), fatigue. sleep disorders, ataxia (motor coordination disorders), speech disorder. From the urinary system: difficulty, and urinary retention.
On the part of the digestive tract: dry mouth, thirst, taste disturbance, dysphagia, decrease intestinal motility until atony, constipation, reducing tone biliary tract and gall bladder.
On the part of the organ of vision: mydriasis, photophobia, paresis of accommodation, temporary blurred vision, increased intraocular pressure.
Cardio-vascular system: facial redness, flushing, palpitations, arrhythmias (including extrasystole, tachycardia), myocardial ischemia, may increase blood pressure.
The respiratory system and organs of the mediastinum: a decrease in the secretory activity and tone bronchi, leading to the formation of viscous mucus that is difficult to cough up.
On the part of the immune system: the manifestations of hypersensitivity reactions, including anaphylactic reaction, anaphylactic shock.
From the side of the track and subcutaneous tissue: skin rash, flushing, urticaria, exfoliative dermatitis.
Other: decreased sweating, dry skin and mucous membranes, dysarthria, edema. strengthening existing hypokalemia.
special instructions
Do not exceed the recommended dose.
In applying the drug should refrain from drinking alcohol.
At high ambient temperatures Bellastezina application can lead to thermal shock (due to inhibition of the activity of the sweat glands).
Effects on ability to drive vehicles, machinery.
In applying the drug should refrain from car driving or working with other mechanisms due to the possible side effects in the nervous system, organ of vision.
Storage conditions
In the dark place at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
Inside, and food.
Adults: 1 tablet 2-3 times a day.
The highest single dose – 2 tablets daily – 5 tablets.
Children older than 6 years: 1/2 tablet 2-3 times a day.
The drug is intended for the symptomatic short-term use. The duration of treatment should not exceed 3 days.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist