Baralginum m Injection 500mg / 5ml ampoules 5 ml Pieces

Description

Composition
Active substance:
1 mL contains: metamizole sodium 500 mg.
Excipients:
Water for injections to 1 mL.
Product form:
A solution of 500 mg / ml, 5 ml ampoule.
Packing 5 ampoules.
Contraindications
Hepatic porphyria; congenital deficiency of glucose-6-phosphate dehydrogenase; I and IIl trimester of pregnancy; bronchial asthma (including aspirin-induced technique, salicylates and other nonsteroidal anti-inflammatory drugs); diseases accompanied bronchospasm; development anaphylactoid reactions (urticaria, rhinitis, swelling) in response to salicylates, paracetamol, diclofenac, ibuprofen, indomethacin, naproxen; expressed by human liver and kidney; pronounced disorders of hematopoiesis (agranulocytosis, tsitoplasticheskaya neutropenia and infection); Neonatal contraindicated aged 3 months with body weight or less than 5 kg; Hypersensitivity to metamizole – active substance and other ingredients, or other pyrazolones (izopropilaminofenazol, propyphenazone, phenylbutazone or phenazone).
In infants aged 3 to 12 months is contraindicated in / route of administration.
Precautions: systolic blood pressure below 100 mm Hg. v., circulatory instability (myocardial infarction, multiple trauma, starting shock), kidney disease (pyelonephritis, glomerulonephritis including history), long abuse ethanol.
Dosage
500 mg / ml
Indications
Pain syndrome of various etiologies (mild to moderate severity);
Fever.
Interaction with other drugs
Simultaneous use of alcohol and metamizol mutually affect their effects. When used in conjunction with cyclosporin may be a reduction in blood concentration of cyclosporine. Simultaneous application metamizol with other non-narcotic analgesics can lead to mutual reinforcement of toxic effects.
Tricyclic antidepressants, oral contraceptives, allopurinol violate metamizol metabolism in the liver and increase its toxicity.
Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the effect metamizol.
Sedatives and tranquilizers increase the analgesic effect of the drug. Concomitant use with chlorpromazine or other derivatives of phenothiazine can lead to severe hyperthermia.
Radiopaque substances, colloidal and penicillin blood substitutes should not be used during treatment metamizole.
Metamizole, displacing connection with protein oral hypoglycemic drugs, indirect anticoagulants glucocorticosteroid agents indomethacin and increases their activity.
Myelotoxic drugs increase the expression gematotoksichnosti drug. Methimazole and sarkolizin increase the risk of leukopenia. The effect of reinforcing codeine, histamine H2-blockers and propranolol.
Due to the high probability of a pharmaceutical incompatibility metamizole should not be mixed with other drugs in the same syringe.
Overdose
You may experience the following symptoms: nausea, vomiting, stomach pain, oliguria, hypothermia, reduced blood pressure, tachycardia, dizziness, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal or hepatic impairment, convulsions, paralysis respiratory muscles.
Treatment is symptomatic. Specific antidote to metamizole does not exist. Perhaps a forced diuresis, hemodialysis; the development of convulsions – in / diazepam and barbiturates fast.
pharmachologic effect
Pharmacological group:
Non-narcotic analgesic agent.
Pharmacodynamics:
Baralginum M refers to non-narcotic agents, derivatives of pyrazolone.
It has analgesic, antipyretic and weak anti-inflammatory action.
Mechanism of action does not differ from other non-steroidal analgesic drugs.
Pharmacokinetics:
After the on / in the T1 / 2 for metamizol at 14 min. Approximately 96% is excreted in the urine as metabolites.
Communication active metabolite to plasma proteins – 50-60%.
Advantageously excreted by the kidneys.
At therapeutic doses, it passes into breast milk.
Pregnancy and breast-feeding
During I and III trimester take Baralgin M impossible. From the fourth to sixth months of pregnancy reception baralgin M should be done under strict medical indications.
Upon receiving Baralginum M breastfeeding should be terminated at 48 hours.
Conditions of supply of pharmacies
On prescription.
side effects
Adverse events were classified as follows: very frequent (> 10%), frequent (> 1
special instructions
In patients receiving cytotoxic agents receive Metamizole should be done only under medical supervision.
During pregnancy, especially in the first 3 months and the last 3 months, you can not apply any nonsteroidal anti-inflammatory agents.
Increased risk of hypersensitivity reactions to sodium metamizole includes: bronchial asthma, especially with the concomitant polyps in the sinuses; in patients with chronic urticaria; in patients with alcohol intolerance; patients intolerant to dyes (e.g., Tartrazine) or preservatives (e.g., benzoate).
With long-term use must be monitored picture peripheral blood. While taking metamizole sodium may develop agranulocytosis, and therefore, the detection of temperature rise unmotivated, chills, sore throat, difficulty swallowing, stomatitis, erosive-ulcerous lesions of the oral cavity, vaginitis, or proctitis, require immediate removal of the drug.
The drug must not be used to treat acute pain in the abdomen (to determine the cause).
In patients with impaired liver function and kidney recommended to avoid receiving Metamizole in high dosages.
When the / m administration must use a long needle.
Storage conditions
Store at a temperature of from 8 ° C to 25 ° C in a dark place. Keep out of the reach of children!.
Dosing and Administration
Adults and adolescents aged 15 years and older: as a single dose is recommended 1-2 ml of 50% (500 mg / 1 ml) Baralginum M solution (w / o or w / w), the daily dose can be up to 4 ml of injection solution (not 2 g), divided into 2-3 doses. The maximum single dose may be 1 g (2 ml of 50% solution).
Children and infants: Baralgin M can not be taken in newborn age 3 months with body weight or less than 5 kg.
Babies Baralgin M administered in a dose of 50-100 mg per 10 kg body weight (0.1-0.2 ml 50% solution).
A single dose may be administered 2-3 times per day. Before administration it is recommended to heat the solution to body temperature.
For children aged 3-12 months of administration is only / m (child’s body weight from 5 to 9 kg).
At too rapid administration of the drug may be a critical drop in blood pressure and shock. B / in the introduction should be administered slowly (rate of introduction of no more than 1 ml (500 mg metamizol) per minute) in the supine position, in the control of blood pressure, pulse and respiratory rate.
Since there is a fear that the fall in blood pressure is dose-dependent non-allergic genesis, Baralginum number M solution of 2 ml (1 g) must be administered with extreme caution.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist