Azelik gel appearance. 15% 30g

Description

Composition
Active substance:
100 g of gel contains azelaic acid, calculated as 100% substance – 15.00 g ;.
Excipients:
Benzoic acid – 0.10 g, methylpyrrolidone – 4.00 g, Squalane – 1.00 g Propylene Glycol – 8.00 g Disodium edetate – 0.10 g sodium hydroxide – 0.25 g Dimethicone 100 cst – 1 , 00 g, macrogol cetostearyl ether – 1.40 g, carbomer interpolymer (type A) – 1.40 g purified water – 100 g
Description:
Gel white or nearly white color, tolerance of weak specific smell.
Product form:
Gel for topical application of 15%.
At 5, 15 or 30 g of aluminum into a tube. Each tube together with instructions for use placed in a pile of cardboard.
Contraindications
Hypersensitivity.
Carefully
Bronchial asthma.
Dosage
fifteen %
Indications
Acne, melasma (including pregnancy) seborrheic dermatitis.
Interaction with other drugs
It may be used in combination with others. PM for treatment of acne.
Overdose
Overdose phenomena when applied externally installed.
pharmachologic effect
Pharmacological group:
Acne treatment for rashes.
Pharmacodynamics:
It has bacteriostatic activity against Propionibacterium acne and Staphylococcus epidermidis, reduces the production of fatty acids, promoting the appearance of acne. Reduces the formation of comedones. Affecting the process cornification of epidermal cells, inhibits the growth and activity of abnormal melanocytes, causing hyperpigmentation, melasma type. It provides anti-acne, depigmenting action.
Pharmacokinetics:
After application to the skin penetrates the epidermis and dermis, 3.6% of the total dose is absorbed into the systemic circulation. Part suck acid excreted by the kidneys in unchanged form part – in the form of dicarboxylic acids (C7, C5) formed as a result of beta-oxidation.
Pregnancy and breast-feeding
Use of the drug during pregnancy and lactation is possible only after consultation with your doctor.
Adequate and well-controlled studies with topical azelaic acid have not been conducted in pregnant women. The study on animals showed no adverse effects of azelaic acid with respect to pregnancy, fetal development, birth or postnatal exposure. The potential risk for humans is unknown. In pregnancy, the drug Azelik® used only if the expected benefit to the mother outweighs the potential risk to the fetus.
Similarly, it is not known whether azelaic acid into breast milk. Given the low systemic absorption of azelaic acid when applied externally, during breastfeeding Azelik® drug is used only if the expected benefit to the mother outweighs the potential risk to the child. When breastfeeding to avoid application of the drug to the area of ​​the mammary glands before feeding; should avoid contact with the skin of children, including the breast skin after application Azelik® drug.
Conditions of supply of pharmacies
Without recipe.
side effects
Observed in the clinical studies and post-marketing surveillance in the most common side effects were: itching, burning and pain at the site of application. The following side effects are listed according to the following gradations their frequency of occurrence (according to the classification of the World Health Organization (WHO)): very common (> 1/10); common (> 1/100, 000 1/1, 1/10, 000,
Disorders of immune system: the frequency is unknown – hypersensitivity reactions (including angioneurotic edema, edema of the eyes, face edema, dyspnea), exacerbation of asthma.
Violations of the skin and subcutaneous tissue disorders: Infrequent – contact dermatitis, acne ** (acne).
General disorders and application site: very often – at the site of itching, burning, pain; often – the site of application: dry, rash, paresthesia, edema **; rarely – the site of application: erythema (redness), desquamation * (detachment of the epidermis), a feeling of warmth * depigmentation (bleaching) of the skin, discomfort ** ** urticaria; the frequency is unknown – on the skin irritation, urticaria. * – for acne; ** – for rosacea.
If any of these instructions side effects are compounded, or if you notice any other side effects not mentioned in the instructions, tell your doctor.
special instructions
For external use only. Avoid contact with the gel in the eye, mouth, and other mucous membranes. In case of accidental contact with the drug on the mucous membranes, including the eyes and mouth should be rinsed with plenty of water. If eye irritation persists, consult a doctor. After each application should hand wash formulation. During treatment of rosacea Azelik® advised not to use cosmetics containing alcohol, alcoholic solutions and astringents, abrasives and peeling agents (peeling). Preparation Azelik® comprises benzoic acid, which can cause skin irritation, irritation of the eyes and mucous membranes, and propylene glycol, which can cause skin irritation. During post-marketing surveillance has been reported rarely in patients with exacerbation of bronchial asthma with topical azelaic acid.
The effect on the ability to operate vehicles, machinery
The drug does not affect the ability to drive vehicles or to engage in other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Storage conditions
At temperatures above 25 ° C. Do not freeze.
Keep out of the reach of children.
Dosing and Administration
For outdoor applications. Before use, the skin is thoroughly washed with pure water, the cream 2 times per day applied to the affected areas of the skin, gently rubbing into the skin. personalized treatment for several months – for the treatment of acne, 3 months – for melasma. Clinical improvement occurs on average after 2-4 weeks. If necessary, repeat the course – a break of 1-2 months.
During treatment it is necessary to protect the skin from the entire solar spectrum. In case of severe irritation of the skin during the first week of treatment, use 1 time a day, perhaps short-term removal of the drug followed by the resumption after the disappearance of symptoms of irritation at the recommended dose.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist