Ascoril 10 pcs Table


Ascoril 10 pcs Table


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Active substance:
1 tablet contains: salbutamol sulfate, salbutamol -equivalent 2 mg, bromhexine hydrochloride 8 mg, 100 mg guaifenesin ;.
Calcium hydrogen phosphate, corn starch, methyl parahydroxybenzoate (methyl paraben), propyl parahydroxybenzoate (propylparaben), purified talc, colloidal silicon dioxide, magnesium stearate.
White, round, flat chamfered tablets and one-way mark.
Product form:
10 tablets in blisters from the light-shielding film PVC – aluminum foil. 1, 2 or 5 packs together with instructions for use placed in a cardboard box.
– increased sensitivity to the drug; – pregnancy, lactation; – tachyarrhythmia, myocarditis; – valvular heart disease; – decompensated diabetes; – hyperthyroidism; – glaucoma; – hepatic or renal failure; – gastric ulcer and duodenal ulcer in the acute stage; – gastric bleeding; – arterial hypertension; – Children up to age 6 years.
Be wary appoint patients with diabetes, gastric ulcer and duodenal ulcer in remission.
8 mg + 100 mg + 2mg
In the combined therapy of acute and chronic bronchopulmonary diseases accompanied by formation of difficult to separate viscous secretion: – bronchial asthma; – tracheobronchitis; – obstructive bronchitis; – pneumonia; – emphysema; – whooping cough; – pneumoconiosis; – pulmonary TB et al.
Interaction with other drugs
Other beta-2 Adrenomimeticalkie funds and theophylline increases the effects of salbutamol and increase the likelihood of side effects.
Ascoril not administered with drugs containing codeine and other antitussive, as this makes it difficult expectoration of liquefied sputum.
Part of the drug Ascoril bromhexine promotes penetration of antibiotics (erythromycin, cephalexin, oxytetracycline) in pulmonary tissue.
Not recommended for use Ascoril drug simultaneously with non-selective beta-adrenoceptor blockers, such as propranolol.
Part of the drug is salbutamol Ascoril not recommended for patients who receive inhibitors of monoamine oxidase (MAO).
Diuretics and drugs glucocorticoids increase hypokalemic effect of salbutamol.
Do not take simultaneously with Ascoril alkaline water.
Symptoms: increased manifestations of side effects.
Treatment: symptomatic therapy.
pharmachologic effect
Pharmacological group:
Expectorant combined means.
Combined preparation has a bronchodilator, an expectorant and mucolytic action. Salbutamol – a bronchodilator and stimulates beta2-adrenergic receptors of the bronchi, blood vessels and myometrium. Prevents or eliminates bronchospasm, reducing airway resistance increases lung capacity. Causes expansion of the coronary arteries, does not lower blood pressure. Bromhexinum – mucolytic agent, has expectorant and antitussive effect. Increases serous components bronchial secretions; cilia activates the ciliated epithelium, lowers the viscosity of sputum, its volume increases and improves expectoration. Guaifenesin – mucolytic agent reduces the surface tension structures bronchopulmonary apparatus; stimulates secretory bronchial mucosa cells that produce neutral polysaccharides depolymerizes acidic mucopolysaccharides, reduces the viscosity of sputum, bronchial activates ciliary apparatus, facilitates the removal of sputum and facilitates the transition nonproductive cough productive.
Salbutamol: ingestion absorption – high. Food intake reduces the rate of absorption, but does not affect the bioavailability. Relationship to plasma proteins – 10%. It crosses the placenta. Undergoes first-pass metabolism in the liver and in the intestinal wall by fenolsulfotransferazy inactivated to 4-O-sulfate ester. The half-life (T1 / 2) -. 3.8-6 hours excreted by the kidneys (69-90%), preferably in the form fenolsulfatnogo inactive metabolite (60%) for 72 hours and in the bile (4%). Bioavailability of orally administered salbutamol is about 50%. Bromhexine: ingestion almost completely (99%) absorbed in the gastrointestinal tract (GIT) for 30 min. Bioavailability – low (primary effect “pass” through the liver). It crosses the placental and blood-brain barriers. The liver is demethylation and oxidation, is metabolised to a pharmacologically active ambroxol. T1 / 2 -15 hr (due to slow reverse diffusion from the tissue). Excreted by the kidneys. In chronic renal failure disturbed the excretion of metabolites. Repeated application may accumulate. Gvayfenezin: absorption from the gastrointestinal tract – fast (25-30 minutes after ingestion). T1 / 2 – 1 h. Penetrates into the tissue containing acidic mucopolysaccharides. Approximately 60% of the administered drug is metabolized in the liver. Light output (sputum) and kidneys in unchanged form and as inactive metabolites.
Pregnancy and breast-feeding
During pregnancy, the drug is not recommended. In need of treatment during lactation should stop breastfeeding.
Conditions of supply of pharmacies
By prescription.
side effects
Rare: when used in high doses can sometimes occur headache, dizziness, irritability, sleep disturbance, drowsiness, tremors, convulsions, nausea, vomiting, diarrhea, acute gastric ulcer and duodenal ulcers, heart palpitations, perhaps urine staining pink , allergic reactions (rash, urticaria), collapse, bronchospasm.
Storage conditions
In a dry, dark place at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
Inside. Adults and children over 12 years: 1 tablet 3 times / day.
Children aged from 6 years to 12 years – 1/2 or 1 tablet 3 times / day.
Children under 6 years of age is recommended to use the syrup “Ascoril expectorant.”
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg


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