Artrozilen caps. 320mg 10 pieces

Description

Composition
Active substance:
ketoprofen lysine salt 320 mg;
Excipients:
diethyl phthalate 2.286 mg 32.857 mg carboxypolymethylene, magnesium stearate, 15.857, 27.857 mg povidone, acrylic and methacrylic acid polymers 34.143 mg Talc 27.000 mg.
capsule shell:
Casing – titanium dioxide (E171), gelatin qsp. Cap – quinoline yellow (E104), indigotine (E132), titanium dioxide (E171), gelatin qsp.
Description:
Hard gelatin capsules are oblong. Body – white; cap – dark green.
Coderzhimoe capsule: pellets circular shape from white to light yellow color.
Product form:
10 capsules in blister PVC / Al-foil. 1 blister pack in a cardboard with instructions for use.
Contraindications
Hypersensitivity (including to other. NSAIDs), “Aspirin” asthma, gastric ulcer and duodenum 12 (exacerbation), ulcerative colitis (exacerbation), Crohn’s disease, diverticulitis, peptic ulcer, hemophilia and others. Coagulation disorders blood, chronic renal failure, children’s age (18 years), pregnancy (III trimester), lactation.
Precautions – anemia, bronchial asthma, alcoholism, smoking, alcoholic cirrhosis,
hyperbilirubinemia, hepatic failure, diabetes, dehydration, sepsis, chronic heart failure, edema, hypertension, blood diseases (including leukopenia), deficiency of glucose-6-phosphate dehydrogenase, stomatitis, advanced age, pregnancy (I, II trimester).
Dosage
320 mg
Indications
Pain relief of mild to moderate intensity, including post-operative pain, post-traumatic pain and inflammatory pain.
Rheumatic diseases:
– Rheumatoid arthritis – spondylitis – osteoarthritis – gouty arthritis – Inflammatory lesion periarticular tissues
Interaction with other drugs
Inductors microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, flumetsinol, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of active hydroxylated metabolites.
Reduces the efficiency of uricosuric drugs, enhances the action of anticoagulants, antiplatelet agents, fibrinolytics, ethanol mineralkortikosteroidov side effects, glucocorticoids, estrogens. Reduces the effectiveness of antihypertensive and diuretics.
Co-administration with other. NSAIDs, corticosteroids, ethanol, corticotropin may lead to the development of ulcers and gastrointestinal bleeding, increase the risk of renal functions.
Simultaneous with the appointment of oral anticoagulants, heparin, thrombolytics, antiplatelet, tsefaperazon, cefamandole and tsefotetanom increases the risk of bleeding.
Increases hypoglycemic effect of insulin and oral hypoglycemic agents (requires recalculation of the dose).
Co-administration of sodium valproate causes disturbance of platelet aggregation. Increases concentration of plasma verapamil and nifedipine, lithium preparations methotrexate. Antacids colestyramine and reduce absorption.
Overdose
Currently, the cases of drug overdose Artrozilen were reported. In case of overdose requires monitoring of respiratory and cardiac function. There is no specific antidote. If necessary, should be symptomatic therapy. Hemodialysis is ineffective.
pharmachologic effect
Pharmacological group:
Nonsteroidal anti-inflammatory drug (NSAID).
Pharmacological properties:
It has anti-inflammatory, analgesic and antipyretic effect. Inhibiting cyclooxygenase type I and II, inhibits the synthesis of prostaglandins. Antibradikininovoy possesses activity stabilizes lysosomal membranes and inhibits the release of these enzymes that contribute to tissue destruction in chronic inflammation. It reduces the release of cytokines, inhibits the activity of neutrophils.
Reduce morning stiffness and swelling of joints, increases range of motion.
Ketoprofen lysine salt, unlike ketoprofen is rapidly dissolving molecule with a neutral pH and almost no irritation to the gastrointestinal tract.
Pharmacokinetics:
Suction. Appointed inwardly, ketoprofen adequately absorbed from the gastrointestinal tract, and its bioavailability is greater than 80%. Maximum plasma concentration at the reception of capsules
Artrozilena observed after 4-10 hours after oral administration, its value directly depends on the dose. The half-life of 6.5 hours. The maximum concentration (Cmax) of Ketoprofen 3-9 ug / ml.
The maximum therapeutic effect is observed for 4 to 24 hours. Food reduces the values ​​of Cmax and increased Tmax – without changing the AUC.
Distribution
Up to 99% of absorbed ketoprofen bound to plasma proteins, mainly albumin.
The volume of distribution – 0.1-0.2 l / kg. Easily it penetrates the blood-tissue barriers and distributed in the tissues and organs.
Ketoprofen is well into the synovial fluid and connective tissue. While ketoprofen concentration in synovial fluid is somewhat lower than in the plasma, they are more stable (stored up to 30 hours).
Metabolism
Ketoprofen is mainly metabolized by the liver, where it undergoes glucuronidation to form esters with glucuronic acid.
breeding
Metabolites are excreted in the urine. Since stool output of less than 1%. The drug does not accumulates.
Pregnancy and breast-feeding
Like other NSAIDs, Artrozilen should not be used in the III trimester of pregnancy. Use of the drug in the I and II trimester should be closely monitored by the attending physician.
Breast-feeding while using this drug should be discontinued.
Conditions of supply of pharmacies
On prescription.
side effects
Gastrointestinal tract: abdominal pain, diarrhea, duodenitis, erosive and ulcerative lesions of the gastrointestinal tract, gastritis, gematomezis, esophagitis, stomatitis, melena.
Liver: increase in bilirubin, increase in “liver” enzymes, hepatitis, hepatic failure, enlarged liver.
Nervous system: dizziness, hyperkinesia, tremor, vertigo, mood swings, anxiety, hallucinations, irritability, malaise.
Senses: conjunctivitis, blurred vision.
Skin: urticaria, angioedema, erythematous rash, itching, makulo-papular rash, increased sweating, erythema multiforme (including Stevens-Johnson syndrome).
Urogenital: painful urination, cystitis, edema, hematuria, menstrual disorders.
Forming Organs: leykotsitopeniya, leukocytosis, lymphangitis, decrease of prothrombin time, purpura, thrombocytopenia, thrombocytopenic purpura, an increase in size of the spleen, vasculitis.
Respiratory system: bronchospasm, dyspnea, throat feeling spasm, laryngospasm, laryngeal edema, rhinitis.
Cardiovascular system: hypertension, hypotension, tachycardia, chest pain, syncope, peripheral edema, pallor.
Allergic reactions: anaphylactoid reactions, swelling of the mouth, throat edema, periorbital edema.
special instructions
During treatment requires monitoring picture peripheral blood and functional state of the liver and kidneys.
If necessary, definition of 17-ketosteroids drug should be discontinued 48 hours before the study.
Acceptance of ketoprofen may mask signs of infection.
If the kidney and liver functions necessary to decrease the dose and careful observation. Use of ketoprofen patients suffering from bronchial asthma, can lead to attacks of bronchial asthma.
Women planning a pregnancy should refrain from taking the drug, because may reduce the likelihood of implantation of the egg.
Storage conditions
At temperatures above 25 ° C, in a dry place.
Dosing and Administration
1 capsule per day during or after a meal. The duration of treatment can be 3-4 months
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist