Artra pi n / v film 500mg + 500mg 120 pcs

Description

Composition
Active substance:
1 tablet contains: glucosamine hydrochloride 500 mg Sodium chondroitin sulfate 500 mg.
Excipients:
Dibasic calcium phosphate – 230 mg Microcrystalline Cellulose – 185 mg, croscarmellose sodium – 80 mg stearic acid – 70 mg Magnesium stearate – 10 mg
Coating: Hydroxypropyl methyl cellulose – 35 mg, titanium dioxide (E171) – 8.2 mg Triacetin – 6.8 mg.
Description:
Oval biconvex tablets, film-coated, white to white color with a yellowish shade, interspersed with «ARTRA» engraved on one side of the tablet, with a specific smell.
Product form:
Film-coated tablets. 30, 60, 100 or 120 film-coated tablets in a white bottle of high-density polyethylene screw cap of the same material and the safety valve of the foil. Per vial glued label vial tightened polyethylene film, together with instructions for use placed in a cardboard box.
Contraindications
Hypersensitivity expressed renal dysfunction.
Precautions: bleeding or bleeding tendency, bronchial asthma, diabetes mellitus.
Dosage
500 mg + 500 mg
Indications
Osteoarthritis of peripheral joints and spine.
Interaction with other drugs
Possible potentiation of anticoagulants and antiplatelet agents. Artra® increases the absorption of tetracycline, reduces the effect of semisynthetic penicillins. The product is compatible with glucocorticoid drugs.
Overdose
Symptoms of overdose cases is unknown. Treatment: gastric lavage, symptomatic therapy.
pharmachologic effect
Pharmacological group:
Tissue regeneration stimulator.
Pharmacological properties:
Stimulates the regeneration of cartilage tissue. Glucosamine and chondroitin sodium sulfate are involved in the biosynthesis of connective tissue to help prevent cartilage destruction processes and stimulating tissue regeneration. Exogenous glucosamine increases the production of cartilage matrix and provide non-specific protection, including the NSAIDs and glucocorticosteroids (GCS). The preparation has a moderate anti-inflammatory action.
Sodium chondroitin sulfate, regardless of whether it is absorbed in an intact form or in the form of individual components, serves as an additional substrate for the formation of healthy cartilage matrix. Stimulates the production of proteoglycans and collagen type II, but also protects the cartilage matrix by enzymatic cleavage (by inhibition of hyaluronidase activity) and from the damaging effects of free radicals; It maintains the viscosity of synovial fluid, stimulates cartilage repair mechanisms and suppresses the activity of those enzymes (elastase, hyaluronidase) that cleave cartilage. It facilitates the treatment of osteoarthritis symptoms of the disease and reduce the need for NSAIDs.
Pharmacokinetics:
The bioavailability of glucosamine orally – 25% (the effect of “first pass” through the liver). Distributed in tissues: highest concentrations found in the liver, kidney, and articular cartilage. About 30% of the dose persist long bone and muscle tissue. Predominantly excreted in the urine unchanged; partially faeces. T1 / 2 -. 68 hours Bioavailability chondroitin sulfate about 13%.
Pregnancy and breast-feeding
Do not take during pregnancy and lactation.
Conditions of supply of pharmacies
Without recipe.
side effects
Glucosamine: possible violations lungs GI function (epigastric pain, bloating, diarrhea, constipation), dizziness, allergic skin reactions.
Chondroitin: allergic reactions.
Storage conditions
At a temperature of 10-30 C, in a dry place. Keep out of the reach of children.
Dosing and Administration
Inside. Adults and children over 15 years: 1 tablet 2 times a day during the first three weeks; 1 tablet 1 time per day during the next weeks and months.
Sustained therapeutic effect is achieved by taking the drug for at least 6 months.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist