Argosulfan cream 2% 40g tube

Description

Composition
Active substance:
1 g of cream contains: sulfathiazole silver – 20 mg.
Excipients:
Cetostearyl alcohol (cetyl alcohol, stearyl alcohol 60% 40%.) – 84, 125 mg, liquid paraffin – 20.0 mg, white petrolatum – 75.9 mg Glycerol – 53.3 mg Sodium lauryl sulfate – 10.0 mg methyl parahydroxybenzoate – 0.66 mg propyl parahydroxybenzoate – 0.33 mg potassium dihydrogen phosphate – 1.178 mg, sodium hydrogen phosphate – 13.052 mg water for injection – up to 1.0 g
Description:
The white to a shade of pink to light gray uniform soft mass.
Product form:
Cream for external use 2%. 15 g and 40 g in aluminum, inside of tube lacquered lithographed. 400 g of polypropylene in boxes (for hospitals). 1 the tube together with instructions for use placed in a cardboard box. 10 boxes of polypropylene together with instructions for use by the number of boxes to prevent shipping carton (for hospitals).
Contraindications
Hypersensitivity to sulfonamides and other sulfathiazole. Congenital deficiency of glucose-6-phosphate dehydrogenase. Prematurity, infants up to 2 months (the risk of “nuclear” jaundice).
Dosage
2%
Indications
Burns of varying degree, of any nature (thermal, solar, chemical, electric current, radiation, etc.); frostbite. Decubitus: leg sores of various origins (including chronic venous insufficiency, obliterating endarteritis, blood circulation disorders in diabetes, erysipelas, etc.); Sores: minor personal injury (cuts, abrasions); Infected dermatitis, impetigo, simple contact dermatitis, microbial eczema; streptostafilodermii.
Interaction with other drugs
Not recommended for use in conjunction with other topical medications. Folic acid and its structural analogs can weaken antimicrobial effect sulfathiazole.
Overdose
Cases of overdose are not logged in.
pharmachologic effect
Pharmacological group:
The antimicrobial agent, sulfanilamide.
Pharmacological properties:
Argosulfan® – topical antimicrobial, promotes healing of wounds (burns, trophic, purulent, etc.), provides effective protection from infection wounds, reduces the time of treatment and the preparation of a wound to skin grafts, in many cases leading to an improvement in condition, eliminates the need for transplantation. Part of the cream sulfanilamide – sulfathiazole silver is bacteriostatic antimicrobial agent has a broad spectrum antibacterial bacteriostatic action against Gram-positive and Gram-negative bacteria. The mechanism of antimicrobial action sulfathiazole – inhibition of growth and reproduction of bacteria associated with a competitive antagonism with para-aminobenzoic acid and inhibition digidropteroatsintetazy, which disrupts the synthesis of dihydrofolic acid and eventually its active metabolite – tetrahydrofolic acid required for the synthesis of purines and pyrimidines microbial cells. Present in the preparation of silver ions enhance antibacterial sulfanilamide – they inhibit the growth and division of bacteria by binding of deoxyribonucleic acid of microbial cells. Moreover, silver ions weaken the sensitizing properties of sulfanilamide. Due to the minimal resorption of the drug it has no toxic effect.
Pharmacokinetics:
Contained in the preparation of silver sulfathiazole, has little solubility, whereby after topical application concentration of the active substance in a wound permanently maintained at the same level. Only a small amount of silver sulfathiazole appears in the bloodstream, and then subjected to acetylation in the liver. Urine is in the form of inactive metabolites and partly in an unmodified form. Absorption increases sulfathiazole silver after the application to extensive wound surfaces.
Pregnancy and breast-feeding
Application Argosulfana® during pregnancy and breast-feeding is allowed in cases where the surface of the burn does not exceed 20% of the surface of the body and when the assessment of the attending physician the potential benefit to the mother prevails over the possible risk to the fetus and child.
Conditions of supply of pharmacies
Without recipe.
side effects
Allergic reactions, local reactions (burning, itching, redness of the skin). With prolonged use may leukopenia, deskvamatozny dermatitis.
special instructions
In hepatic and / or renal failure is necessary to control the concentration of sulfathiazole in serum. Care must be taken when used in patients in shock with extensive burns, due to inability to fully collect allergic history. Effects on ability to drive vehicles and mechanisms The drug does not limit the ability of the mind-body, road management capacity and maintenance of machinery in motion.
Storage conditions
Store at a temperature of from 5 C to 15 C. Do not freeze. Keep out of the reach of children.
Dosing and Administration
Externally – as a method of open and under occlusive dressings. After cleansing and debridement of the wound with the formulation applied under sterile conditions and 2-3 mm thickness 2-3 times per day. The wound at the time of treatment should be completely covered with cream. If part of the wound open, you must also apply the cream. Imposition of occlusive dressings – is possible, but is not mandatory. The cream is applied until complete healing of wounds or until skin grafting. In case the drug can exudate appear on infected wounds. Before applying the cream must clean the wound with 0.1% aqueous chlorhexidine or other antiseptic. The maximum daily dose – 25, the maximum duration of treatment – 60 days.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist