Anti-angina formula spray mest.pr. 25ml

Description

Composition
Active substance:
1 dose / 100 ml of the preparation contains:
Chlorhexidine digluconate 0.24 mg / 0.120 g as a 20% solution of chlorhexidine bigluconate 1.20 mg / g 0.600
Tetracaine hydrochloride 0.12 mg / g 0.060
Excipients:
Glycerol 85% – 60.00 mg / 30.00 g of ethanol 96% – 80.00 mg / 40.00 g aspartame – 0.20 mg / 0.10 g, mint flavoring – 2,00 mg / 1, 00 g propyl parahydroxybenzoate – 0.20 mg / 0.10 g anhydrous citric acid – 0.02 mg / 0.01 g purified water – up to 200 mg / 100 g
Description:
Spray in a plastic bottle with a metering valve action.
The contents of the vial – colorless liquid with an odor of mint.
Product form:
Spray for topical application dosage.
25 ml of the drug (dose 100) placed in a plastic bottle with a metering valve acts in a cardboard package with instructions for use.
Contraindications
Hypersensitivity to the drug, damage or inflammation of the mucous membranes, vysokovaskulyarizirovannyh areas, phenylketonuria, children’s age (10 years).
Precautions: Pregnancy and lactation, diabetes, deficiency of glucose-6-phosphate dehydrogenase deficiency, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, oksaloze and urolithiasis.
Dosage
0.6 mg + 1.2 mg / ml
Indications
Prevention, etiotropic and symptomatic therapy of infectious and inflammatory diseases of the mouth and throat, caused by susceptible microorganisms to chlorhexidine (pharyngitis, tonsillitis, the initial stage of angina, periodontitis, stomatitis, gingivitis, post-tonsillectomy or tooth extraction, etc.). Integrated angina therapy (used at the first signs of the disease – with a sore throat and scratchy).
Interaction with other drugs
Sucrose, polysorbate 80, insoluble magnesium salts, zinc and calcium is reduced effect of chlorhexidine.
Tetracaine reduces the antibacterial activity of sulfonamides.
Vasoconstrictors prolong the effect and reduce toxicity.
Drugs that inhibit cholinesterase (antimiastenicheskie agent, cyclophosphamide, thiotepa, etc.), Tetracaine reduce metabolism and increase its toxicity. Anticoagulants (dalteparin sodium, enoxaparin sodium, heparin sodium, warfarin) increase the risk of bleeding. When using tetracaine with drugs that inhibit monoamine oxidase (furazolidone, procarbazine, selegiline), an increased risk of blood pressure reduction. Tetracaine effect enhances and prolongs miorelaksirutee medicaments. Beta-blockers slow the metabolism tetracaine, increasing its toxicity (decrease in hepatic blood flow).
Overdose
Overdose symptoms: dizziness, weakness, cyanosis, agitation, anxiety, muscle tremors, respiratory failure, nausea, vomiting.
Treatment: gastric lavage, the appointment of laxatives; symptomatic therapy.
pharmachologic effect
Pharmacological group:
Antiseptic + local anesthetic.
Pharmacological properties:
Chlorhexidine may have bactericidal and bacteriostatic effect.
It has a broad antibacterial spectrum of action against gram-positive and gram-negative bacteria, active against Candida albicans. Chlorhexidine especially active against Streptococcus mutans, Streptococcus salivarius, Escherichia coli and anaerobic bacteria. Less effective against microbial species such as a Streptococcus spp., Proteus spp., Pseudomonas, Klebsiella spp.,
Veillonella spp.
Tetracaine has local anesthetic action.
Pharmacokinetics:
Tetracaine easily and completely absorbed through mucous membranes. Binding to plasma proteins is high. Fully hydrolyzed cholinesterase for 1-2 hours to form compounds of para-aminobenzoic acid. Excreted by the kidneys and in bile, the exposed part of the intestinal and hepatic recirculation.
No clinical data chlorhexidine absorption through the oral mucosa of man. Chlorhexidine may be stored in the saliva to 8 hours. Practically not absorbed from the gastrointestinal tract. Write mainly through the intestine (90%), less than 1% excreted by the kidneys.
Pregnancy and breast-feeding
Only after consultation with your doctor.
Conditions of supply of pharmacies
Without recipe.
side effects
Allergic reactions mucosa burning mouth.
special instructions
The spray should not be inhaled. Avoid getting product in eyes.
If after 3 days after the start of treatment the symptoms do not disappear or there is deterioration in the disease course, you must determine the appropriateness of its further use.
Children can apply the drug to 10 years, the child must be able to hold their breath during injection of the drug. Before the drug is necessary to consider that one dose (1 injection) contains 83 mg of absolute ethanol.
The drug should be taken no later than 30 minutes before the start of driving. Subject to the recommendation on the ability to drive vehicles and management mechanisms The drug has no effect.
It is not recommended to use simultaneously with drugs for the treatment of the oral cavity and throat, containing iodine (Lugol’s iodine, povidone-iodine).
Storage conditions
Store at a temperature not higher than 25 C. Keep out of reach of children !.
Dosing and Administration
Locally. The preparation is sprayed onto the mucosa of the mouth and throat during breath-hold.
Adults and children over 15 years: 1-2 injections of accepting up to 6 times a day.
Children from 10 to 15 years: 1-2 injections of accepting up to 3 times a day.
The course of treatment no more than 5 days.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist