Angiovit tab n / about 60 pc

Description

Composition
Active substance:
Folic acid – 5 mg
Pyridoxine hydrochloride – 4 mg
Cyanocobalamin – 0.006 mg
Excipients:
For tablet-core weight of 0.20 g:
Sucrose (granulated sugar) -118.761 mg
-47.528 mg Potato starch
Croscarmellose sodium (primelloza) – 18.705 mg
Talc – 4,000 mg
Calcium stearate – 2.000 mg
For shell weighing 0.14 g:
Sucrose (granulated sugar) – 72.477 mg
Wheat flour -30.637 mg
Basic magnesium carbonate – 29.140 mg
Titanium dioxide – 6.655 mg
Methylcellulose – 0.405 mg
Gelatin – 0.306 mg
Sunflower oil – 0.162 mg
Beeswax – 0.143 mg
Talc – 0.075 mg
Tablet weight: – 0.340 g of
Description:
Round, biconvex white film-coated. In the cross-sectional two layers are visible.
Product form:
Film-coated tablets. 10 tablets in blisters. 6 the contour of cellular packages together with instructions for use placed in a pile of cardboard.
Contraindications
Increased sensitivity to the drug; children’s age, the period of breast-feeding; deficit sucrase / isomaltase, fructose intolerance, glucose-galactose malabsorption.
Indications
Prevention of vitamin deficiencies that make up the product; hyperhomocysteinemia.
Interaction with other drugs
Folic acid.
Reduces the effect of phenytoin (dose required to increase it).
Analgesics (chronic treatment), anticonvulsants (including phenytoin and carbamazepine), estrogens, oral contraceptives increase the demand for folic acid.
Antacids (including aluminum and magnesium preparations), colestyramine, sulfonamino (including sulfasalazine) reduce the absorption of folic acid.
Methotrexate, pyrimethamine, triamterene, trimethoprim inhibit dihydrofolate reductase and reduced folate effect.
Pyridoxine hydrochloride.
It enhances the effect of diuretics; It weakens the activity of levodopa.
Isonicotinyl hydrazide, penicillamine, cycloserine and estrogen-containing oral contraceptives weaken the effect of pyridoxine.
Well combined with cardiac glycosides (pyridoxine promotes synthesis of contractile proteins in the myocardium), glutamic acid and asparkamom (increased resistance to hypoxia).
Cyanocobalamin.
Aminoglycosides, salicylates, antiepileptic drugs, colchicine, potassium drugs reduce the absorption of cyanocobalamin.
It increases the risk of allergic reactions against the backdrop of thiamine.
Can not be combined with drugs that increase blood clotting
Overdose
Increased symptoms of side effects of the drug – skin rash, pruritus, erythema, nausea, dizziness.
The first is to help washing gastrointestinal tract, activated charcoal, symptomatic therapy.
pharmachologic effect
Pharmacological group:
Multivitamin agent.
Pharmacological properties:
Pharmacological properties Angiovit® drug due to the action of B vitamins included in its composition.
Folic acid – is involved in the synthesis of amino acids, DNA and RNA stimulates erythropoiesis. Folic acid reduces the risk of miscarriage in early pregnancy, and prevents the occurrence of congenital fetal malformations of the cardiovascular and nervous systems of the fetus, and limbs malformations associated with a deficiency of folic acid proceeds during fetal development.
Vitamin B12 (cyanocobalamin) – participates in many metabolic processes required for DNA synthesis. Cyanocobalamin is involved in the formation of the myelin sheath of nerve fibers of the component; cyanocobalamin at deficiency during pregnancy the fetus may slow the formation of the myelin nerve sheath. Increases the resistance of erythrocytes to hemolysis.
It enhances the ability to regenerate tissues.
Vitamin B6 (pyridoxine) – participates in metabolism; necessary for normal functioning of the central and peripheral nervous system. Warns of nausea and vomiting in toxicosis pregnant. It fills pyridoxine deficiency, which can occur in the case of oral contraceptives before pregnancy.
B vitamins (folic acid, vitamins B6 and B12) play an important role in the metabolism of homocysteine. Angiovit® has the ability to activate the key enzymes in the body and transsulfuratsii remethylation methionine – methylenetetrahydrofolate and tsistation-B synthase, resulting in acceleration of methionine metabolism and decrease in the blood concentration of homocysteine. Homocysteine ​​is predictive of the pathological changes in the human body (cardiovascular disease, pregnancy abnormalities, neuropsychiatric disorders). On the background of using said complex vitamins normalization of homocysteine ​​levels in the blood.
Pharmacokinetics:
Folic acid is rapidly absorbed in the small intestine, undergoing rehabilitation and methylation to 5-methyltetrahydrofolate, which is present in the portal circulation. The maximum plasma concentration observed after 30-60 minutes after administration. Vitamin B12 is absorbed after reacting it in the stomach with the “intrinsic factor”, glycoprotein that is secreted from the gastric parietal cells.
The maximum plasma concentration observed after 8-12 hours. As in the case of folic acid, vitamin B12 undergoes significant gastro-hepatic recirculation.
Both components are largely bound to plasma proteins, excess accumulates in the liver.
Daily 4-5 mcg folate excreted in the urine in the form of folic acid, 10-formiltetragidrofolata and 5-methyltetrahydrofolate. Folate is also excreted in breast milk. The average half-life of vitamin B12 is about 6 days. Part of the administered dose is excreted in the urine during the first 8 hours
most of the excreted in the bile. On average, 25% of the metabolites excreted in the feces. Vitamin B12 crosses the placenta and is present in breast milk.
Vitamin B6 is readily absorbed in the gastrointestinal tract and converted by the liver into pyridoxal phosphate (the active form of the vitamin). The blood is carried out in non-enzymatic conversion of pyridoxine, pyridoxamine, whereupon a part of the final exchange product – 4-piridoksilovaya acid. The tissue by phosphorylating pyridoxine converted into piridoksinfosfat, pyridoxal phosphate and piridoksaminfosfat. Pyridoxal conversion product is 4-and 5-piridoksilovaya fosfopiridoksilovaya acid. Both of these products are excreted in the urine by the kidneys.
Conditions of supply of pharmacies
Without a prescription
side effects
Allergic reactions.
special instructions
Ability to influence the reaction rate when driving or operating other mechanisms: The drug does not affect the ability to drive or operate dangerous machinery.
Pregnancy and lactation: During pregnancy, the drug is used according to indications in order to prevent the development of the fetus with congenital hyperhomocysteinemia, with a neural tube defect in history.
Folic acid enters the breast milk. During breast-feeding is not recommended to use the drug.
Storage conditions
At a temperature of not higher than 25 degrees. Keep out of the reach of children.
Dosing and Administration
Inside, 1 tablet per day regardless of the meal.
The course of treatment 20 – 30 days. If necessary, repeat the treatment prescribed by a doctor.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist