Analgin tab 500mg 20 pieces Medisorb

Description

Composition
Active substance:
1 tablet contains: Metamizole (dipyrone) 500 mg ;.
Excipients:
Sucrose (sugar), potato starch, calcium stearate, talc.
Description:
Tablets white or white with a slightly yellowish white color, Valium forms a facet and Valium.
Product form:
Tablets of 500 mg.
10 pieces in blisters.
10 pieces in the package contour bezgyachakova. 1, 2, 5 or contour of cellular bezgyachakova packaging together with instructions for use placed in a pile of cardboard.
Placing permitted outline package together with an equal number of instructions for use in multipacks.
Contraindications
hypersensitivity; hemopoiesis depression (agranulocytosis, cytostatic or infectious neutropenia); liver and / or renal failure; hereditary hemolytic anemia associated with a deficiency of glucose-6-dehydrogenase-fosfatdegidro; bronchial asthma induced by the admission of acetylsalicylic acid, salicylates or other nonsteroidal antiinflammatory drugs.; anemia; leukopenia; age up to 8 years.
Precautions kidney disease (pyelonephritis, glomerulonephritis – including history); long-term abuse of ethanol; diabetes mellitus (due to the presence of sugar).
Dosage
500 mg
Indications
Febrile syndrome (infectious and inflammatory diseases, insect bites – mosquitoes, bees, horseflies and other post-transfusion complications); pain (mild to moderate severity) including neuralgia, myalgia, arthralgia, trauma, burns, decompression sickness, shingles, orchitis, sciatica, myositis, postoperative pain, headache, toothache, tuberculosis. pain in bile, intestinal, renal colic – in conjunction with the appointment antispasmodics.
Interaction with other drugs
Metamizole amplifies the effects of ethanol.
Radiopaque drugs, and penicillin colloidal blood substitutes should not be used during treatment metamizole sodium.
With simultaneous use of cyclosporine reduced concentration of the latter in the blood.
With simultaneous application of sodium metamizole displaces an active protein iuvelichivaet oral hypoglycemic drugs, anticoagulants, corticosteroids; indomethacin.
With simultaneous use of sedatives and antianxiety drugs (anxiolytics) increase the analgesic action Metamizole.
With simultaneous use of codeine blockers H2-histamine receptors, increase the effect of propranolol (slow inactivation) Metamizole.
With simultaneous application phenylbutazone, barbiturates and others. Gepatoinduktory Metamizole reduce efficiency.
The simultaneous use of other non-narcotic analgesics, tricyclic antidepressants, hormonal contraceptive drugs, allopurinol may lead to increased toxicity Metamizole.
Simultaneous application myelotoxic drugs enhances expression gematotoksichnosti drug.
With simultaneous use of methimazole and cytotoxic agents increase the risk of leukopenia.
Overdose
Symptoms include nausea, vomiting, gastralgia, oliguria, hypothermia, blood pressure, tachycardia, dyspnea, tinnitus, drowsiness, lightheadedness, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and / or liver failure, seizures, paralysis of the respiratory muscles .
Treatment: gastric lavage, saline laxatives, activated carbon; carrying out forced diuresis, hemodialysis, with the development of seizures – intravenous diazepam and barbiturates fast.
pharmachologic effect
Pharmacological group:
Non-narcotic analgesic agent.
Pharmacological properties:
Metamizole – non-narcotic analgesic agent, a pyrazolone derivative, nonselective cyclooxygenase blocks and reduces the formation of prostaglandins from arachidonic acid.
Impedes pain extra- and proprioceptive pulses of beams Gaulle Burdach, increases excitability threshold centers thalamic pain sensitivity that increases heat transfer.
The distinguishing feature is the low intensity of the anti-inflammatory effects to produce a weak influence on the water-salt metabolism (delay sodium and water) and the mucosa of the gastrointestinal tract. It has analgesic, antipyretic and spasmolytic some (in smooth muscle of the urinary and biliary tract) effect.
Action develops within 20-40 minutes after oral administration and reaches a peak after two hours.
Pharmacokinetics:
Good and is rapidly absorbed in the gastrointestinal tract.
In the wall of the intestine is hydrolyzed to form the active metabolite – unmodified metamizole sodium in the blood is absent (only after the on / in the minor its concentration detected in the plasma).
Communication active metabolite of protein – 50-60%.
It is metabolized in the liver, kidneys displayed.
At therapeutic doses, it passes into breast milk.
Pregnancy and breast-feeding
Analgin is contraindicated in pregnancy (I and III trimester) and lactation. In the II trimester of pregnancy the drug is possible only for health reasons.
Conditions of supply of pharmacies
Without a prescription.
side effects
From the urinary system: renal failure, oliguria, anuria, proteinuria, interstitial nephritis, urine staining in red.
From the side of hematopoiesis: agranulocytosis, leukopenia, thrombocytopenia.
Allergic reactions: urticaria (including the conjunctiva and the nasal mucous membranes), angioneurotic edema, in rare cases – malignant erythema multiforme (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome), bronchospastic syndrome, anaphylactic shock.
Other: lowering blood pressure.
special instructions
In the treatment of patients receiving cytotoxic drugs receive Metamizole should be done only under medical supervision.
Intolerance occurs rarely, but the threat of anaphylactic shock after injection vnutrivennogno relatively higher than after ingestion of the drug. In patients with atopic asthma and hay fever have an increased risk of allergic reactions.
While taking metamizole sodium agranulocytosis may develop, due to which the detection unmotivated rise in temperature, fever, sore throat, difficulty swallowing, stomatitis, and the development of phenomena of vaginitis, or proctitis require immediate removal of the drug. With long-term use must be monitored picture peripheral blood.
Not be used to treat acute pain in the abdomen (to determine the cause).
Perhaps staining of urine red due to excretion of metabolites (does not matter).
Storage conditions
In a dry place, protected from light.
Keep out of the reach of children.
Dosing and Administration
Analgin should be used inside for children 14 years and adults of 250 – 500 mg of (1/2 – 1 tablet) 2-3 times a day with a maximum single dose – 1000 mg (2 tablets) daily – 3000 mg (6 tablets ).
Single dose for children 8-14 years – 250 mg, the multiplicity of purposes – 2-3 times a day.
The preparation is not applied (without consultation with a physician) over 3 days when administered as antipyretic and more than 5 days – when administered as an analgesic.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist