Ampicillin 250mg tab 20 pc

Description

Composition
Active substance:
1 tablet contains: Ampicillin trihydrate (calculated as active substance) – 0.25 g
Excipients:
Starch, magnesium stearate, talc.
Product form:
Tablets of 0.25 g 10 tablets in blisters. 1 or 2 outline package together with instructions for use in putting a pile of cardboard.
Contraindications
Individual hypersensitivity (including to other penicillins, cephalosporins, carbapenems), infectious mononucleosis, severe hepatic dysfunction, breast-feeding (at the time of treatment must be suspended).
Dosage
250 mg
Indications
Ampicillin trihydrate used in pneumonia, bronchopneumonia, pulmonary abscess; peritonitis; sepsis; sore throat; infections, including mixed, urinary and biliary tracts (pyelitis, pyelonephritis, cystitis, cholangitis, cholecystitis); infections of the gastrointestinal tract, including salmonellezonositelstve; soft tissue infections, and other infections caused by susceptible microorganisms to antibiotics.
Interaction with other drugs
Ampicillin trihydrate reduces the effect of oral contraceptives increases – anticoagulants, aminoglycoside antibiotics series. Allopurinol increases the likelihood of skin rash. Probenecid while the use of ampicillin reduces tubular secretion of the latter, resulting in increased ampicillin concentration in blood plasma and increases the risk of toxic action.
Overdose
Symptoms manifest toxic effect on the central nervous system (especially in patients with renal insufficiency).
Treatment: symptomatic (maintenance of vital functions).
pharmachologic effect
Pharmacological group:
Antibiotic semisynthetic penicillin.
Pharmacodynamics:
Ampicillin trihydrate – antibiotic group semisynthetic penicillins. Antibacterial (bactericidal) activity. It is active against a broad spectrum of gram-positive (alpha- and beta-haemolytic streptococci, Streptococcus pneumoniae, Starhylococcus spp., Except for strains producing penicillinase, Bacillus anthracis, Clostridium spp., Enterococcus spp.) And gram negative (Haemophilus influenzae, Neisseria meningitidis, Neisseria gonorrhoeae, Salmonella spp., Proteus mirabilis, Listeria monocytogenes, Shigella spp., Escherichia coli, Bordetella pertussis) microorganisms. Decompose penicillinase and therefore does not act on penitsillinazoobrazuyuschie strains of pathogens.
Pharmacokinetics:
In the gastrointestinal tract is absorbed 40-60% of the dose. Maximum concentration in blood reached 1.5-2 hours after administration. Penetrates the tissues and body fluids. It is not destroyed in the acidic environment of the stomach. Excreted mainly by the kidneys in unchanged form. In urine are high concentrations of the unchanged antibiotic. Partly excreted in the bile, in nursing mothers – with milk. For repeated administrations do not accumulates, which makes it possible to use ampicillin trihydrate long.
Conditions of supply of pharmacies
On prescription.
side effects
Allergic reactions (urticaria, erythema, angioedema, rhinitis, conjunctivitis, rarely – fever, joint pain, eosinophilia, rarely – anaphylactic shock), nausea, vomiting, intestinal dysbiosis, colitis caused by C. difficale, oral candidiasis, vaginal candidiasis.
special instructions
In the treatment of ampicillin trihydrate requires systematic monitoring of liver function, kidney and peripheral blood picture. Patients with impaired renal function requires a correction mode in accordance with the values ​​of creatinine clearance. When high doses of the drug in patients with renal insufficiency possibly toxic effects on the central nervous system.
In bronchial asthma, hay fever and other allergic states simultaneously administered desensitizing agents. When liver failure ampicillin trihydrate is used under the control of the functional state of the liver.
Storage conditions
In a dry, dark place at a temperature not higher than 25 ° C. In the reach of children.
Dosing and Administration
The mode set individually, depending on the severity and localization of infection, the sensitivity of the pathogen to the drug.
Ampicillin trihydrate taken orally without food. Single dose for adults is 0.25-0.5 g daily – 1-3 Babies of drug administered in a daily dose of 50-100 mg / kg body weight. Children weighing up to 20 kg are given at 12.5-25 mg / kg. The daily dose is divided into 3-4 receptions.
Duration of therapy Ampicillin trihydrate is determined individually depending on the severity of the disease form and the effectiveness of treatment.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist