Amlodipine 10mg tabs 30 pcs ozone

$0.73

Amlodipine 10mg tabs 30 pcs ozone

5 in stock

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SKU: 0695173951 Categories: , , Tags: ,

Description

Composition
Active substance:
1 tablet contains: amlodipine 5 mg or 10 mg.
Product form:
Tablets of 5 mg and 10 mg. 10, 30 tablets in blisters of PVC film and aluminum foil printed patent. 10, 20, 30, 40, 50 or 100 tablets in banks of PET for drugs sealed with lids screw-with the control of the first opening or the system “push – turn” of polypropylene or polyethylene or banks polypropylene for drugs sealed with lids tensioned control the first opening of polyethylene or polypropylene jars for drugs sealed with lids tensioned to control the first opening of the high-pressure polyethylene. One jar or 1, 2, 3, 4, 5, 6, 8 or 10 contour of cellular packaging together with instructions for use placed in a cardboard box (pack) of cardboard.
Contraindications
– increased sensitivity to amlodipine and other dihydropyridine derivatives, as well as to other components of the formulation; – hemodynamically unstable heart failure after myocardial infarction; – obstruction of the left ventricular outflow tract (including severe aortic stenosis); – severe hypotension (systolic blood pressure less than 90 mmHg..); – Shock, including cardiogenic; – unstable angina (except Prinzmetal angina) – pregnancy and lactation; – the age of 18 years (effectiveness and safety have been established). – lactose intolerance, lactase deficiency syndrome and glucose-galactose malabsorption (formulation contains lactose).
Dosage
10 mg
Indications
Arterial hypertension (monotherapy or in combination with other antihypertensive agents), and vasospastic angina (Prinzmetal’s angina).
pharmachologic effect
Pharmacological group:
Blockers “slow” calcium channels. ATC code C08CA01.
Pharmacological properties:
Blocker “slow” calcium channel (BCCI), a dihydropyridine derivative, has antianginal and antihypertensive action. Blocking calcium channels, reduces the transmembrane passage of calcium ions into the cell (mainly in vascular smooth muscle cells than cardiac myocytes). Antianginal due to increased coronary and peripheral arteries and arterioles: – angina reduces the severity of myocardial ischemia; expanding peripheral arterioles, reducing the total peripheral vascular resistance, reduces afterload on the heart, reducing myocardial oxygen demand; – expanding the coronary arteries and arterioles in the unaltered and in ischemic areas of myocardium, increase oxygen supply to the myocardium (especially with vasospastic angina pectoris); prevents coronary artery spasm (including those caused by smoking). In patients with stable angina single daily dose increases exercise tolerance, slows the development of angina and ‘ischemic’ ST segment depression, reduces the frequency of angina attacks and consumption of nitroglycerin and other nitrates. It has a long dose-dependent antihypertensive effect. The antihypertensive action is due to the direct vasodilating effect on vascular smooth muscle. When hypertension single dose provides a clinically significant decrease in blood pressure (BP) over 24 hours (with the patient “lying” and “standing”). Orthostatic hypotension when using amlodipine is quite rare. Does not cause reduction of exercise tolerance, left ventricular ejection fraction. Reduces the degree of left ventricular hypertrophy. No effect on the myocardial contractility and conductivity, does not cause reflex increase of heart rate (HR), inhibits platelet aggregation and increases glomerular filtration rate, has a weak natriuretic action. In diabetic nephropathy does not increase the severity of microalbuminuria. It does not have any adverse effect on metabolism and lipid concentration in blood plasma and can be used for therapy of patients with asthma, diabetes and gout. Significant decrease in blood pressure observed after 6-10 hours, duration of effect – 24 hours. In patients with cardiovascular disease, including coronary atherosclerosis lesion with one vessel to the stenosis and 3 or more arteries, carotid atherosclerosis, myocardial infarction, percutaneous transluminal angioplasty (PTCA) or coronary arteries of patients with angina pectoris, amlodipine prevents the development intima-media thickening of carotid arteries, reduces mortality from myocardial infarction, stroke, PTCA, coronary w ntirovaniya; reduces the incidence of unstable angina and progression of chronic heart failure (CHF); It reduces the frequency of interventions aimed at restoring coronary blood flow. It does not increase the risk of death or complications and mortality in patients with chronic heart failure (III-IV functional class NYHA classification) during therapy with digoxin, diuretics and angiotensin-converting enzyme (ACE) inhibitors. In patients with CHF (III-IV NYHA functional class classification) with nonischemic etiology amlodipine exists the likelihood of pulmonary edema.
Conditions of supply of pharmacies
Prescription.
Dosing and Administration
Inside, once a day, washing down the necessary amount of water (100 mL). When hypertension and angina is 5 initial dose of 1 mg once a day. In the absence of a therapeutic effect for 2-4 weeks the dose can be increased to a maximum daily dose of 10 mg. In elderly patients, amlodipine recommended for use in medium therapeutic dose, dose adjustment is required. In patients with impaired liver function Despite the fact that the T1 / 2 of amlodipine, as well as all the BCCI, is increased in patients with hepatic impairment, dose adjustment is not usually required. In patients with renal impairment is recommended to use amlodipine in normal doses, but must take into account a possible slight increase in T1 / 2. Not required dose change while the appointment with thiazide diuretics, beta blockers and angiotensin converting enzyme inhibitors (ACE.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

OZONE generics

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